Time-Restricted Eating on Appetite and Inflammation in Adults With Obesity and Prediabetes: A Randomized Feeding Study.
Time-restricted eating produces weight loss similar to standard eating, but not through hunger or inflammation changes, suggesting other mechanisms underlie its metabolic effects.
The TRIM study (12 weeks, n=39) randomized adults with obesity and prediabetes/diet-controlled T2DM to 10-hour TRE or 16-hour usual eating pattern under isocaloric eucaloric feeding conditions. No significant between-group differences were observed in appetite hormone levels, inflammatory biomarkers, or self-reported eating behaviors, despite equivalent weight loss in both arms—suggesting TRE's cardiometabolic benefits do not operate primarily through appetite or inflammatory mechanisms.
What the study was
- Study design
- randomized_controlled_trial
- Population
- Adults with obesity and prediabetes or diet-controlled T2DM (n=39, TRIM study)
- Sample size
- 39
- Category
- Prevention
- Maturity
- Exploratory
- Journal
- Obesity (Silver Spring)
Why it surfaced
Well-controlled isocaloric RCT (Obesity journal) providing mechanistic clarification that TRE's metabolic effects are not driven by appetite hormone modulation or reduced inflammation—important negative result for understanding the biological basis of TRE interventions, though underpowered (n=39).
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