Validated 1-Year Mortality Prediction in Patients with Three-Vessel Disease Undergoing Contemporary PCI: Insights from the Multivessel TALENT trial.
A clinical risk score accurately predicts one-year survival better than anatomical measures alone in patients undergoing modern heart procedures, improving risk stratification.
Post-hoc analysis of the TALENT RCT (1,548 patients with three-vessel coronary artery disease undergoing contemporary PCI, 3.0% 1-year mortality) validated the logistic clinical SYNTAX Score (LCSS) as achieving moderate discrimination (AUC 0.716-0.744) versus the anatomical SYNTAX Score (AUC 0.629), with recalibration improving model fit. Decision curve analysis supported the LCSS as the preferred mortality stratification tool for current PCI practice.
What the study was
- Study design
- secondary_analysis_of_rct
- Population
- Three-vessel coronary artery disease patients undergoing contemporary PCI (n=1,548, TALENT RCT; 3.0% 1-year mortality)
- Sample size
- 1548
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Eur Heart J Qual Care Clin Outcomes
Why it surfaced
Validation study (Eur Heart J Qual Care) recalibrating SYNTAX-based risk tools for contemporary PCI in three-vessel disease—provides evidence-based clinical decision support for patient stratification in coronary revascularization planning.
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