Cancer drug response and resistance: molecular mechanisms and combating strategies.
A comprehensive framework synthesizing resistance mechanisms across 22 cancer types offers a strategic roadmap for choosing which drugs to pursue in the clinic.
Published in Signal Transduction and Targeted Therapy, this landmark review systematically examines molecular and cellular determinants of drug resistance for 22 cancer types, contextualized across chemotherapy, targeted therapy, and immunotherapy modalities with clinical trial support. The review presents a strategic framework for precision oncology incorporating single-cell omics, PDO/PDX models, and AI-driven resistance prediction—providing a synthesis valuable for pipeline prioritization.
What the study was
- Study design
- review
- Category
- precision_oncology_genomics
- Maturity
- Validated
- Journal
- Signal Transduct Target Ther
Why it surfaced
Authoritative review in high-impact journal covering the field-defining challenge of cancer drug resistance across all modalities with clinical trial evidence; essential reference for precision oncology pipeline contextualization.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.