PubMed Daily Triage Digest — 2026-08-06

Run: attempt 2 · 2026-08-06T09:14:45Z
Window: 2026-08-05 → 2026-08-06 (CRDT)
Topics scanned: 9 watchlist + sentinel
Articles reviewed: 101 candidates across topics (capped per topic)
Selected: 30 total · 18 HIGH · 11 MEDIUM · 1 LOW

🔴 HIGH Priority

Hematologic Malignancies (T1) — 36 found, 15 reviewed, 3 HIGH

[PMID 42554861] Vara LP et al. · Virchows Arch · 2026-08-05
Ki-67 Expression in megakaryocytes: A new prognostic marker in Myelodysplastic Syndromes
Score: 9/10 · Novel biomarker | human | retrospective_cohort | restricted
Ki-67 in MDS megakaryocytes independently predicts prognosis from routine bone marrow biopsy, offering a new T1-assessable biomarker beyond IPSS-R. Direct MDS prognostic gap addressed.

[PMID 42555529] Pérez-Aguilera M et al. · Hematol Oncol · 2026-08-05
Decoding the Heterogeneity of Diffuse Large B-Cell Lymphomas: A Comprehensive Genetic, Transcriptomic, and Phenotypic Profiling of B-Cell Lymphoma Cell Lines
Score: 8/10 · DLBCL multi-omic | in_vitro | restricted
Comprehensive multi-omic profiling of DLBCL cell lines by a large Spanish group maps molecular subtypes, creating a research resource for targeted DLBCL experiments.

[PMID 42555493] Teng Y et al. · Hell J Nucl Med · 2026-08-06
Tumor necrosis and ascites on baseline 18F-FDG PET/CT as independent prognostic imaging markers for double/triple-hit lymphoma
Score: 8/10 · DHL/THL imaging prognostics | human | retrospective_cohort | restricted
PET/CT imaging features (tumor necrosis, ascites) independently predict outcomes in aggressive DHL/THL, improving risk stratification from universally available staging imaging.

CBC/ML Hematology (T2) — 2 found, 2 reviewed, 2 HIGH

[PMID 42553493] Alaoui YE et al. · Biomed Eng Comput Biol · 2026-08-02
AI-Based Computational Model Integrating Routinely Acquired Blood Parameters for Triage and Early Detection of Acute Myeloid Leukemia
Score: 9/10 · AI+CBC → AML | human | computational_modeling | open access (PMC13434900)
AI model uses routine CBC for AML early detection — pragmatic, no additional tests required, scalable to primary care. Top cross-topic hit (T1+T2).

[PMID 42552856] Shang L et al. · Int J Lab Hematol · 2026-08-05
AI-Enabled Automated Schistocyte Classification in Peripheral Blood for TMA Auxiliary Diagnosis
Score: 8/10 · AI morphology | human | diagnostic_accuracy | restricted
AI schistocyte quantification system addresses labor-intensive manual morphology for TMA diagnosis, reducing variability in a time-critical clinical scenario.

Early Cancer Detection (T3) — 2 found, 2 reviewed, 1 HIGH

[PMID 42553790] Lyu G et al. · Front Genet · 2026-07-22
Predictive value of peripheral blood cfDNA breast cancer gene mutation profiling for postoperative pathological malignancy in BI-RADS 4 breast nodules
Score: 8/10 · cfDNA | human | prospective_cohort | open access (PMC13436921)
cfDNA mutation profiling from blood predicts malignancy in BI-RADS 4 nodules—could reduce unnecessary biopsies across millions of ambiguous mammograms annually. Also T5 hit.

AI/ML Clinical Diagnostics (T4) — 28 found, 15 reviewed, 2 HIGH

[PMID 42553749] Stambollxhiu E et al. · Eur Heart J Digit Health · 2026-07-20
Deep learning-derived biological age from preoperative chest radiographs predicts mortality following surgical and transcatheter procedures for structural heart disease beyond EuroSCORE II
Score: 9/10 · DL biological age | human | retrospective_cohort | open access (PMC13436687)
DL-extracted biological age from routine chest X-ray outperforms/augments EuroSCORE II for cardiac surgery and TAVI mortality prediction. High clinical utility via universally available imaging.

[PMID 42553869] Xiong S et al. · Infect Drug Resist · 2026-07-31
Predicting Helicobacter pylori Antibiotic Resistance from Routine HE Histopathology Using a Vision-Language Model-Guided Foundation Model Framework
Score: 7/10 · VLM+foundation model | human | diagnostic_accuracy | open access (PMC13436092)
Novel VLM+foundation AI framework predicts H. pylori resistance from existing HE slides, enabling culture-free, rapid treatment personalization.

Novel Therapeutics: Immunotherapy / CAR-T / Targeted (T6) — 63 found, 15 reviewed, 4 HIGH

[PMID 42555643] Zhao S et al. · PNAS · 2026-08-11
Checkpoint-insulated triple-signal artificial antigen-presenting cells drive antigen relay and systemic antitumor immunity
Score: 9/10 · Novel aAPC platform | mouse | preclinical_in_vivo | restricted
PNAS: novel checkpoint-insulated triple-signal artificial APC platform drives systemic antitumor immunity via antigen relay—mechanistic advance for solid tumor immunotherapy.

[PMID 42555723] Wang G et al. · Sci Adv · 2026-08-07
Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity
Score: 8/10 · Novel mechanism | mouse | preclinical_in_vivo | restricted
Science Advances: cold atmospheric plasma reprograms immunosuppressive tumor neutrophils—entirely novel biophysical approach to reshape tumor immune microenvironment.

[PMID 42556028] Zhang K et al. · Drug Resist Updat · 2026-08-02
ITPKB suppresses ER calcium release to promote CXCL9 expression and enhance immunotherapy sensitivity in triple-negative breast cancer
Score: 8/10 · ITPKB-CXCL9-TNBC | human | mechanistic | restricted
Novel ITPKB-ER calcium-CXCL9 axis drives immunotherapy sensitivity in TNBC—identifies mechanistic target for sensitizing TNBC to immunotherapy.

[PMID 42556016] Bo Z et al. · Comput Biol Chem · 2026-07-31
Pan-cancer multi-omics machine learning defines a lactylation-associated immune-excluded tumor state with proteomic and experimental corroboration
Score: 7/10 · Lactylation + immune exclusion | human | computational | restricted
Pan-cancer ML links lactylation to immune-excluded tumor state + immunotherapy resistance—novel histone modification as immunotherapy target. Lower-tier journal; confidence low pending replication.

Cardiovascular-Metabolic (T7) — 61 found, 15 reviewed, 2 HIGH

[PMID 42555307] Wang X et al. · IEEE J Biomed Health Inform · 2026-08-05
Deep Learning-based Automated Segmentation of Ultra-Widefield Retinal Vasculature for Cardiometabolic Disease Association Analysis
Score: 7/10 · DL retinal vasculature | human | computational | restricted
DL retinal vasculature segmentation enables large-scale quantitative cardiometabolic risk association studies. Non-invasive window into systemic vascular health.

[PMID 42555521] Teleka S et al. · Eur Heart J · 2026-08-05
Periodontitis, epicardial adipose tissue and coronary events: the Swedish Cardiopulmonary Bioimage Study
Score: 7/10 · SCAPIS cohort | human | prospective_cohort | restricted
European Heart Journal SCAPIS cohort: periodontitis → epicardial adipose tissue → coronary events. Large population data supporting oral-CV inflammation link.

Aging, Longevity & Population Health (T8) — 25 found, 15 reviewed, 3 HIGH

[PMID 42554263] Kim BH et al. · Alzheimers Dement · 2026-08
Epigenetic aging in Alzheimer's disease: Relation to proteome
Score: 9/10 · ADNI | human | observational_cohort | restricted
ADNI cohort: epigenetic aging acceleration in AD linked to proteomic signatures—multi-omic biomarker discovery at aging-neurodegeneration interface. High-impact AD journal.

[PMID 42554491] Candeloro M, Ferrucci L et al. · J Cachexia Sarcopenia Muscle · 2026-08
Skeletal Muscle Function Deficit Longitudinal Associations With Inflammation and Caloric Intake in Elderly. The InCHIANTI Study
Score: 9/10 · InCHIANTI longitudinal | human | prospective_cohort | restricted
InCHIANTI longitudinal cohort (Ferrucci, NIA): inflammation + caloric intake drive skeletal muscle decline in aging. Strong mechanistic insights for sarcopenia prevention.

[PMID 42554301] Penalba-Sánchez L et al. · Alzheimers Dement · 2026-08
BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI
Score: 8/10 · LC neuroimaging | human | cross_sectional | restricted
Alzheimers Dement: locus coeruleus MRI integrity correlates with fMRI memory networks in MCI—novel neuroimaging biomarker for early cognitive aging.

Rare Diseases with High Unmet Need (T9) — 9 found, 9 reviewed, 1 HIGH

[PMID 42552689] Abrams CK, ToPIC:CMT Steering Committee et al. · J Peripher Nerv Syst · 2026-09
Clinical Development of Therapies for Charcot-Marie-Tooth Disease: Recommendations for Trial Design, Endpoints, and Regulatory Pathways
Score: 8/10 · CMT consensus guidance | human | narrative_review | restricted
ToPIC:CMT consensus recommendations for CMT therapy trials—urgently needed with multiple gene therapies advancing and no approved treatments for any CMT subtype.

🟡 MEDIUM Priority

⚪ LOW Priority

Coverage Notes

• T1 false positives excluded: 42555542 (neuroendocrinology mouse study), 42555391 (achalasia meta-analysis), 42554811 (herbicide chemistry), 42555867 (JCO editorial no abstract)
• T4 false positives excluded: 42554683 (career advice editorial), 42555933 (study protocol only), 42553932 (MRI scheduling ML—out of clinical scope)
• T6 excluded: 42555777 (letter to editor), 42555786 (cellular therapy nursing review)
• T7 excluded: 42554964 (letter/no abstract), 42555438 (fitness/exercise study)
• T8 excluded: 42555703 (pedestrian-robot study), 42555778 (myeloma nursing article), 42554329 (Hungarian article only), 42555703 (autonomous robot safety—not aging)
• T9 excluded: 42553706 (student wellness protocol), 42553335 (Mondor's disease, minimal unmet need), 42554320 (oncofertility—not rare disease per se)
• Sentinel notable: 42556007 (CD103+ TILs in HNSCC / anti-PD-1, MEDIUM score ~5, not included above); 42556022 (antifungal agents review, out of focus)

Generated by Friday (OpenClaw) · Attempt 2 of 3 · 2026-08-06T09:14:45Z