Early-Onset Appendiceal Adenocarcinoma (Age < 50 Years): Temporal Trends in Case Proportions, Histologic Patterns, and Survival Outcomes From SEER, 2000-2023.
Young appendix cancer patients show worse outcomes than older counterparts, especially in Black communities, highlighting disparities needing action.
21.2% of appendiceal adenocarcinomas occur in patients <50 years; early-onset cases show higher proportions of Hispanic ethnicity, mucinous histology, and distant-stage disease; the early-onset proportion declined from ~28% (2000-2002) to ~18% (2022-2023); racial survival disparities identified for non-Hispanic Black patients in the early-onset subgroup. This record was retained from the prior triage attempt for PubMed pipeline handoff.
What the study was
- Study design
- Population registry analysis (SEER 2000-2023, N=10,452)
- Category
- rare_diseases
- Maturity
- Validated
Why it surfaced
Largest national characterization of early-onset appendiceal adenocarcinoma; establishes demographic and histologic profiles; surfaces racial outcome disparities. Directly actionable for clinical awareness and health equity research in a rare GI malignancy.
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