Circulating microRNAs: a new era in early detection of oral squamous cell carcinoma (OSCC) - a systematic review and meta-analysis.
Blood microRNA panels show promise for early oral cancer detection in high-risk populations, though standardization is needed before clinical use.
This systematic review and meta-analysis synthesizes published data on blood-based circulating miRNA diagnostic accuracy for OSCC detection, evaluating sensitivity, specificity, and AUC across multiple published miRNA panels. Results support the clinical potential of liquid biopsy miRNA profiling for early-stage OSCC identification in high-risk populations, though inter-study heterogeneity in panel composition and platform methodology requires resolution before clinical implementation.
What the study was
- Study design
- Systematic Review and Meta-Analysis
- Population
- OSCC patients vs. healthy controls in diagnostic accuracy studies for circulating miRNAs
- Category
- Early Detection
- Maturity
- Validated
- Journal
- Journal of the Egyptian National Cancer Institute
Why it surfaced
Systematic review and meta-analysis on miRNA liquid biopsy for OSCC; provides pooled evidence for an underserved early-detection domain with high global cancer burden.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.