Actionable genotypes beyond the coding sequence and their association…
Researchers found that rare genetic variants in gene promoters independently predict lifespan, suggesting doctors should screen beyond coding sequences when assessing inherited disease risk.
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A stromal-immune computational pathology signature for prognosis and…
A deep-learning biomarker combining immune and stromal features better predicts immunotherapy response in bladder cancer than existing tests, potentially guiding treatment selection.
Early cancer detection or preventionIntegrated Methylation and Copy Number Analysis for Noninvasive…
A new urine test combining DNA and methylation analysis outperforms individual components, offering a practical home-based alternative to cystoscopy for bladder cancer surveillance.
Novel or significantly improved treatmentRNA terminal uridylyl transferases are druggable vulnerabilities in…
Blocking TUT4/7 enzymes kills leukemia cells while sparing normal blood cells in mice, opening a therapeutic window rarely seen in blood cancer research.
Novel or significantly improved treatmentN-glycans in non-malignant tumor microenvironment cells dampen CAR-T…
Disabling a specific sugar-processing pathway in immune cells restores CAR-T therapy effectiveness against hard-to-treat intestinal and pancreatic cancers.