Daily digest · Fri · 14 Aug 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

42594932 · Haematopoietic stem cell transplantation in hepatosplenic T-cell lymphoma: a retrospective... · 9/10 · 🟠 Novel or significantly improved treatment Allo-HSCT achieved 3-year PFS 50.5% and OS 55.0% in 94 HSTL patients (largest series); auto-HSCT had higher 3-year relapse incidence (50.0% vs 37.9%) ...
42595015 · Real-World Experience With TRBC1 Immunohistochemistry Across Cutaneous T-Cell Lymphoma Sub... · 9/10 · 🟢 Near-term implementable finding TRBC1 IHC achieved 85.8% sensitivity, 79.8% specificity, and 83.3% accuracy for T-cell clonality in 665 CTCL biopsies (566 patients) vs paired TCR seq...

42595652 · Translating single-cell RNA sequencing into monocyte direct leukocyte subpopulation-transc... · 8/10 · 🟢 Near-term implementable finding scRNA-seq analysis of monocyte subpopulations yielded two simple leukocyte transcript abundance ratios (IFI27/PSAP, IFI27/CTSS) clinically validated f...

42593771 · Tissue-Free vs Tumor-Informed ctDNA Assays for Molecular Residual Disease Detection in Ear... · 9/10 · 🔴 Early cancer detection or prevention Tissue-free ctDNA assay (cancer-differential methylation) detected MRD in 34% of TNBC patients with HR 27.2 for recurrence; tissue-free detection prec...

42595038 · Artificial Intelligence-Enabled Electrocardiography for Monitoring Serum Potassium Dynamic... · 8/10 · 🟢 Near-term implementable finding AI-ECG correlated strongly with lab-measured K+ (rmcorr 0.847; 95%CI 0.81-0.88) during supplementation; AUC 0.920 for K+≤3.5 mmol/L; ECG-K+ preceded l...
42595369 · Diagnostic accuracy of electronic medical record retrieval methods and a large language mo... · 8/10 · 🟢 Near-term implementable finding Zero-shot LLM workflow achieved highest AUC for stroke (0.920), MI (0.938), and composite MACE (0.880) in Cohort 1 (ICI-treated, n=2,258); outperforme...
42595195 · Artificial intelligence-driven transformation in the management of atypia of undetermined ... · 8/10 · 🟢 Near-term implementable finding Multi-modal AI integrating ultrasound features, cytopathological data, and molecular markers shows promise for reclassifying AUS (Bethesda III/IV) thy...

42594031 · SPEN inactivation drives resistance to androgen receptor pathway inhibitors in metastatic ... · 9/10 · 🟠 Novel or significantly improved treatment SPEN inactivation identified as top enzalutamide resistance hit in genome-wide loss-of-function screen; validated in n=6,828 real-world mCRPC cohort (...
42595654 · Efficacy of Olaparib Plus Abiraterone for Patients with Metastatic Castration-resistant Pr... · 8/10 · 🟠 Novel or significantly improved treatment In 28.4% of PROpel mCRPC patients with HRR gene mutations, BRCA2 conferred strongest benefit (rPFS HR 0.20, OS HR 0.20); ATM and CDK12 showed numerica...

42594032 · Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Par... · 9/10 · 🟠 Novel or significantly improved treatment Dual LAG-3/PD-1 blockade (IBI110+sintilimab) achieved 51.8% ORR (including 4 CRs) in 28 advanced ASPS patients, exceeding expected <40% for single PD-...

42595461 · Association of Peri-procedural Glucagon-Like Peptide-1 Receptor Agonist Exposure with Long... · 8/10 · ⚪ Promising but preliminary Peri-procedural GLP-1RA exposure associated with significantly lower 5-year ischemic stroke risk after CAS (HR 0.436; 21.3% vs 28.1%) and CEA (HR 0.53...

42595186 · Thymus Regeneration in Countering Immunosenescence: Mechanisms, Strategies and Future Pers... · 8/10 · ⚪ Promising but preliminary Reviews thymic regeneration strategies shown effective in preclinical and early clinical settings: GH/IGF-1 axis modulation, IL-7/KGF cytokine therapy...

No high-priority finds today (best candidate scored 7/10)

CBC-based diagnostics and machine learning in hematology

42592411 · Diagnostic Efficacy of the International System for Reporting Serous Fluid Cytop... · 6/10 · Diagnostics

Early cancer detection

42594169 · Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liqui... · 7/10 · Diagnostics
42594382 · A Prospective, Multi-Site Study of Performance of Cell-Free DNA Testing for Rece... · 7/10 · Early Detection

Novel therapeutics

42595354 · Development of an immunocompetent cutaneous squamous cell carcinoma model identi... · 7/10 · Drug Development
42595355 · Turning off methylglyoxal stress: an alternative approach to inhibit MDSC expans... · 7/10 · Drug Development
42595201 · Oncolytic Virus-Delivered CEACAM6/CD3 BiTEs Combine with PD-1 Blockade to Achiev... · 7/10 · Drug Development

Cardiovascular-metabolic

42595732 · Liraglutide and Beta-Cell Function in Young Adults With Long-Standing Type 1 Dia... · 7/10 · Treatment Innovation
42595648 · Identification and management of sarcopenia in patients with multimorbidity: An ... · 7/10 · Prevention

Rare diseases with high unmet need

42594001 · Gene Therapy for Hearing Loss: From Concept to Clinical Reality... · 7/10 · Treatment Innovation
42593952 · Developmental Profiles Associated with TUBA1A, TUBB2A, TUBB2B, and TUBB3 Tubulin... · 7/10 · Genomics/Precision Medicine

None this run.

By research category: Diagnostics: 7, Treatment Innovation: 6, Genomics/Precision Medicine: 3, Drug Development: 3, Early Detection: 2, Prevention: 1
By evidence maturity: Validated: 12, Exploratory: 9, Potentially Practice-Changing: 1
By watchlist topic: Hematologic malignancies: reviewed 15, kept 2, best 9/10; CBC-based diagnostics and machine learning in hematology: reviewed 2, kept 2, best 8/10; Early cancer detection: reviewed 15, kept 3, best 9/10; AI/ML in clinical diagnostics and imaging: reviewed 15, kept 3, best 8/10; Precision oncology and genomic medicine: reviewed 15, kept 2, best 9/10; Novel therapeutics: reviewed 15, kept 4, best 9/10; Cardiovascular-metabolic: reviewed 15, kept 3, best 8/10; Aging, longevity, and population health: reviewed 7, kept 1, best 8/10; Rare diseases with high unmet need: reviewed 10, kept 2, best 7/10
By source type: peer_reviewed: 22
Topics with zero 8+ articles this run: Rare diseases with high unmet need

Attempt 2 of 3; repaired from salvage bundle 2026-08-14-attempt1-20260814T090000Z-salvage.json
All v1.3 schema fields corrected: record_dates, source_db, source_type, publication_type, matched_watchlist_topics, unsolicited_find, pipeline_ready, notes, evidence_maturity enum, access_level enum, classification_confidence enum, pipeline_priority enum, priority_flag_code, plain_summary
Authors and publication dates sourced from live PubMed esummary API fetch
Sentinel scan: 10 candidates reviewed; all overlapped with watchlist topics; unsolicited_find=false for all
Score breakdowns preserved from salvage; all sums verified against triage_score
ERROR/PARTIAL: Aging/longevity topic: only 7 articles found in CRDT window after humans[MeSH] filter; PARTIAL_SUCCESS due to reduced aging topic coverage
ERROR/PARTIAL: CBC-ML diagnostics topic: only 2 articles found in CRDT window; all reviewed