Clinical relevance of TCI score-based refinement of conditioning intensity in cord blood transplantation for myelodysplastic syndrome.
A registry of bone marrow transplants for blood disorders shows how conditioning intensity should shift by age, providing practical guidance for individualized treatment selection.
This nationwide Japanese registry study of 1127 MDS patients demonstrates age-specific effects of conditioning intensity, with higher TCI increasing mortality in older patients while reducing relapse in middle-aged patients. Findings provide a practical TCI-guided conditioning selection framework for MDS cord blood transplantation across age groups.
What the study was
- Study design
- Nationwide registry-based retrospective cohort; 1127 de novo MDS patients undergoing CBT 2008-2022 (Japan).
- Population
- 1127 de novo MDS patients who underwent cord blood transplantation, stratified by age group.
- Sample size
- 1127
- Category
- Treatment Innovation
- Maturity
- Validated
- Journal
- Transplantation and Cellular Therapy
Why it surfaced
Large nationwide registry (n=1127) validating TCI score for age-adapted conditioning in MDS CBT; directly applicable to transplant clinical practice.
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