Mechanism of neoantigen generation and advances in neoantigen-based immunotherapies in colorectal cancer.
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. Conventional therapeutic modalities-such as surgery, chemotherapy, and radiotherapy-yield suboptimal outcomes in advanced or recurrent disease, while immune checkpoint inhibitors demonstrate durable clinical benefit almost exclusively in the microsatellite instability-high (MSI-H) subset, which constitutes only ~ 15% of CRC cases.
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. Conventional therapeutic modalities-such as surgery, chemotherapy, and radiotherapy-yield suboptimal outcomes in advanced or recurrent disease, while immune checkpoint inhibitors demonstrate durable clinical benefit almost exclusively in the microsatellite instability-high (MSI-H) subset, which constitutes only ~ 15% of CRC cases.
What the study was
- Study design
- Review
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Med Oncol
Why it surfaced
Matched watchlist topic 'Rare diseases with high unmet need'. Study design: Review. Score: 8/10 (N:3, R:3, D:1, P:1).
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.