📅 PUBMED DAILY TRIAGE — 2026-08-22 Window: 2026-08-21T00:00:00Z → 2026-08-22T23:59:59Z (CRDT) Topics scanned: 10 | Articles reviewed: ~114 candidates | Kept in output: 56 High priority: 14 | Standard: 42 | Low/archive: 0 | Unsolicited finds: 4 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
42629429 · Response kinetics following CAR T-cell therapy for large B-cell lymphoma: a LYSA · 9/10 · At month 1, 49.1% of LBCL patients achieved CR; among 484 with incomplete response, 35.5% subsequent 42629608 · Use of selective serotonin reuptake inhibitors and risk of myeloid malignancy: A · 8/10 · Nationwide Danish case-control study (n=22,293 cases, 445,860 controls) found SSRI use was not signi 42629427 · A randomized pilot trial comparing anti-thymocyte globulin with anti-thymocyte g · 8/10 · In this randomized pilot trial (n=79 AML/MDS patients), adding post-transplant cyclophosphamide (PTC
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
42630043 · A Novel Index Consisting of Age, CA19-9, and Methylated Somatostatin Is Useful f · 9/10 · The novel ACAm-S index (combining age, CA19-9, and methylated somatostatin) achieved 91.0% sensitivi 42628796 · Bile extracellular vesicles for early cholangiocarcinoma detection in primary sc · 9/10 · Bile-derived extracellular vesicles yielded protein biomarkers capable of early cholangiocarcinoma d 42627756 · Ultrasensitive circulating tumor DNA analysis improves detection of molecular re · 9/10 · Ultrasensitive ctDNA analysis using MAESTRO-Pool detected molecular residual disease (MRD) in locall
AI/ML in clinical diagnostics and imaging
42629289 · Artificial Intelligence-Assisted Chest Radiography: A Prospective Crossover Mult · 9/10 · Prospective crossover evaluation of four commercial AI systems for chest radiography showed variable 42629153 · Systematic assessment of the medical utility of radiology and diagnostic Artific · 9/10 · SAMURAI-fracture is a multicentre cluster-RCT protocol designed to rigorously evaluate AI-assisted f
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42630182 · Neoadjuvant therapy combined with immunotherapy for anal sphincter preservation · 7/10 · Systematic review and meta-analysis demonstrates that neoadjuvant therapy combined with immunotherap
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42630042 · Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision · 9/10 · Critical review of 47 international obesity guidelines (2014–2026) reveals inconsistent translation 42629262 · Comparative risks of dementia and Parkinson's disease with GLP-1 RAs versus othe · 9/10 · GLP-1 receptor agonists were associated with significantly reduced risk of dementia and Parkinson's 42629417 · Psychiatric and eye disorders associated with use of glucagon-like peptide 1 rec · 8/10 · Pharmacovigilance analysis identified spontaneous adverse reaction signals for psychiatric disorders
Aging, longevity, and population health
42630086 · Joint changes in subjective memory and objective cognition and risk of incident · 9/10 · Harmonized analysis of four international aging cohorts demonstrates that concurrent decline in both 42629322 · Nutritional Strategies for Targeting Biological Age. · 8/10 · Caloric restriction, Mediterranean diet, intermittent fasting, and targeted micronutrient supplement
Precision oncology and genomic medicine
No high-priority finds today (best candidate scored 7/10)
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate scored 4/10)
Rare diseases with high unmet need
No high-priority finds today (best candidate scored 7/10)
Sentinel scan
No high-priority finds today (best candidate scored 7/10)
🟢⚪ STANDARD (4-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
42630001 · Distinct clinical and genetic characteristics of myelodysplastic syndrome i · 7/10 · Genomics/Precision Medicine 42628650 · Observational Comparison of Overall Survival between Phase 1b Orca-T and Re · 7/10 · Treatment Innovation 42629454 · BrECADD in three days: Implementation of a condensed intensive first-line r · 6/10 · Treatment Innovation 42629590 · PKM2 modulation regulates leukemia cell survival. · 5/10 · Drug Development 42629604 · Declining treatment-related and overall mortality in children with newly di · 5/10 · Treatment Innovation
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
42630020 · The Local Effects of Systemic Therapies in Urological Oncology: A Systemati · 7/10 · Treatment Innovation 42629684 · Cervical cancer screening predictors in Tanzania: a variance component mode · 6/10 · Early Detection 42629522 · Racial and/or Ethnic Differences in Adherence to Preventive Care Guidelines · 6/10 · Early Detection 42629352 · miRNA-mediated metabolic reprogramming is associated with recurrence in ova · 6/10 · Early Detection 42628452 · Surface-enhanced Raman spectroscopy for breast cancer personalized manageme · 6/10 · Early Detection
AI/ML in clinical diagnostics and imaging
42628011 · Automating Diagnosis of Skin Neglected Tropical Diseases via Patient Metada · 7/10 · Diagnostics 42629440 · A deep learning-derived risk score model from digital pathology to forecast · 6/10 · Diagnostics 42629286 · Multimodal Transformer Fusion of Clinical Information, Medical Text, and Pi · 6/10 · Diagnostics 42628171 · Privacy, security, and reliability risks of artificial intelligence in heal · 6/10 · Diagnostics 42627997 · Unlocking the epigenetic code: future Frontiers in predictive biomarkers fo · 6/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42630013 · Cost‑effectiveness of first‑line immunotherapy-based combination regimens f · 7/10 · Treatment Innovation 42629959 · Impact of Immunotherapy Prescribing Restrictions on Time to Systemic Therap · 7/10 · Treatment Innovation 42629973 · CD7 CAR-T cells eliminate chronic myeloid leukemia stem cells specifically · 7/10 · Treatment Innovation 42629972 · Impact of Molecular Alterations on Survival in Biliary Tract Cancers: A Ret · 6/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42629471 · Tumor Necrosis is Associated with an Increased Metastatic and Cardiovascula · 7/10 · Diagnostics 42629330 · Time-varying cardiovascular risk of febuxostat versus allopurinol in gout: · 7/10 · Prevention 42629533 · Impact of Menopause and Menopausal Hormone Therapy on Liver-Kidney-Metaboli · 6/10 · Prevention 42629510 · Beyond LDL-C: Modern Lipid Management for ASCVD Prevention in Primary Care. · 6/10 · Prevention 42629488 · Evaluation of Alysis-001 cuffless blood pressure estimation algorithm again · 6/10 · Diagnostics
Aging, longevity, and population health
42630084 · Integrated digit-in-noise testing for hearing and cognitive screening. · 6/10 · Diagnostics 42629743 · A cross-sectional latent class analysis of depressive and anxiety symptoms · 6/10 · Mental Health 42629441 · Temporal Trends in Multimorbidity Patterns in Patients With Atrial Fibrilla · 6/10 · Public Health 42629135 · Chemokine receptor CX3CR1 modulates microglial activity through Tau and amy · 5/10 · Drug Development 42629128 · Microglia in Alzheimer's disease: Insights into disease progression and the · 5/10 · Drug Development
Precision oncology and genomic medicine
42630178 · Prevalence and clinical impact of PIK3CA and PTEN alterations from reflex g · 7/10 · Genomics/Precision Medicine 42626283 · Commercial price variation in precision oncology testing across US hospital · 7/10 · Genomics/Precision Medicine 42628300 · Genomic Profiling, Risk Stratification, and Post-Transformation Treatment O · 6/10 · Genomics/Precision Medicine 42628218 · Mechanisms linking the gut microbiota to colorectal cancer development and · 6/10 · Genomics/Precision Medicine 42627456 · Genomic landscape of ERCC alterations in breast and gynecological cancers: · 6/10 · Genomics/Precision Medicine
CBC-based diagnostics and machine learning in hematology
42626262 · The significance of blood indicators in distinguishing bipolar disorder dep · 4/10 · Diagnostics
Rare diseases with high unmet need
42629505 · Clinical characteristics and treatment strategies of brainstem lesion in ch · 7/10 · Treatment Innovation 42627278 · Challenges in the management of Melkersson-Rosenthal syndrome: a case repor · 6/10 · Treatment Innovation 42629751 · Small intestine melanosis caused by clofazimine: A case report. · 4/10 · Other
💡 UNSOLICITED FINDS
42630216 · Serum interleukin-10 levels and mortality in severe fever with thrombocytopenia · 7/10 · Meta-analysis demonstrates that elevated serum IL-10 levels are significantly associated with increa 42630193 · Association of alkalization therapy with long-term survival in stage IV or recur · 7/10 · Alkalization therapy was associated with improved long-term survival in stage IV or recurrent colore 42630181 · Time to adjuvant chemotherapy after cytoreductive surgery and survival outcomes · 6/10 · The interval between cytoreductive surgery and adjuvant chemotherapy initiation significantly affect 42630145 · The predictive value of malnutrition on the prognosis of severe respiratory fail · 6/10 · Malnutrition is a significant independent predictor of poor prognosis in severe respiratory failure
📊 TODAY'S BREAKDOWN
By research category: Treatment Innovation: 15 Diagnostics: 13 Prevention: 8 Early Detection: 7 Genomics/Precision Medicine: 7 Drug Development: 3 Mental Health: 1 Public Health: 1 Other: 1
By evidence maturity: Exploratory: 34 Validated: 22
By watchlist topic: [reviewed / kept in output / highest score] Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): reviewed=15 / kept=10 / best=9 CBC-based diagnostics and machine learning in hematology: reviewed=1 / kept=1 / best=4 Early cancer detection (liquid biopsy, ctDNA, cfDNA): reviewed=15 / kept=8 / best=9 AI/ML in clinical diagnostics and imaging: reviewed=15 / kept=7 / best=9 Precision oncology and genomic medicine: reviewed=15 / kept=8 / best=7 Novel therapeutics: immunotherapy, CAR-T, targeted therapy: reviewed=15 / kept=7 / best=7 Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: reviewed=15 / kept=8 / best=9 Aging, longevity, and population health: reviewed=15 / kept=7 / best=9 Rare diseases with high unmet need: reviewed=3 / kept=3 / best=7 Sentinel scan: reviewed=10 / kept=0 / best=7
By source type: peer_reviewed 56 | preprint 0
Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology, Precision oncology and genomic medicine, Rare diseases with high unmet need, Sentinel scan
🔧 RUN NOTES
- Window: CRDT 2026-08-21 → 2026-08-22 (1-day incremental; last successful run 2026-06-27)
- 10 topics searched; 114 unique PMIDs fetched and reviewed via esummary + efetch XML
- T2 CBC/ML: 1 candidate found (42626262, psychiatric CBC differentiation); no fallback triggered
- T9 Rare diseases: 3 candidates found; all 3 included as STANDARD
- False positives identified and scored LOW: T1 (ICH rehab, rectal cancer MDS-term), T3 (Alzheimer's proteomics), T4 (neuroscience αSMA, post-stroke neurology), T6 (trophoblast, antifungal)
- Sentinel: 4 unsolicited finds (SFTS IL-10 meta-analysis, CRC alkalization therapy, ovarian cancer chemo timing, malnutrition in respiratory failure)
- 14 HIGH articles (13 score≥8, +1 score=7 elevated by NOVEL_TREATMENT flag: 42630182)
- No window expansion triggered; sufficient articles found