📅 PUBMED DAILY TRIAGE — 2026-08-27 Window: 2026-08-26T09:15:25Z → 2026-08-27T09:15:25Z (CRDT) Topics scanned: 9 | Articles reviewed: 110 | Candidates evaluated: 110 High priority: 10 | Standard: 35 | Low/archive: 0 | Unsolicited finds: 3 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
• PM42648372 · Clinical and procedural outcomes of IVUS-guided versus angiography-guided PCI in unprotect · 8/10 · S: Four RCTs comprising 1446 patients were included. • PM42647866 · Survival Improvement of DLBCL Patients Treated with Third Line and Beyond in the Recent Er · 6/10 · OS significantly improved in Era 2 compared with Era 1 (HR=0.70, P=0.01), with 2-year OS of 43% vers
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate scored 5/10)
Early cancer detection
• PM42645357 · Targeted Therapy in Pancreatic Ductal Adenocarcinoma: Current Advances and Challenges. · 9/10 · s: Pancreatic cancer is driven mainly by somatic changes in KRAS, TP53, CDKN2A, and SMAD4. • PM42648416 · The Expanding Functional Landscape of GSTP1 in Cancer Beyond Detoxification. · 6/10 · Future research focusing on these unresolved areas will deepen our understanding of GSTP1's complex • PM42646630 · The PD Effluentome-A Multi-Omics Atlas Defining the Composition, Transport Dynamics, and M · 6/10 · s: A total of 207 metabolites and 2970 proteins were identified in PD effluent. • PM42645170 · Targeting PPAR-Regulated Pathways to Treat Cholestatic Liver Diseases: Novel Applications · 6/10 · This review explores the application(s) of liquid biopsy-derived EVs for the identification of PPAR • PM42648526 · RNA biosensors in oncology: Mechanisms, Cancer-specific applications, and a Hallmark-align · 5/10 · Convergence with microfluidic integration, AI assisted interpretation, and multiplexed nanotechnolog
AI/ML in clinical diagnostics and imaging
No high-priority finds today (best candidate scored 7/10)
Precision oncology and genomic medicine
• PM42647673 · Precision oncology in breast cancer: Biomarker-driven treatment strategies and the expandi · 6/10 · In HR-positive disease, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors and next-generation selectiv
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
• PM42647409 · Evidence of genetic susceptibility to immune-related dermatitis in patients with melanoma · 8/10 · We identified two SNPs associated with dermatitis and subsequently developed a two-SNP PRS that was
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
No high-priority finds today (best candidate scored 7/10)
Aging, longevity, and population health
• PM42645661 · Advanced glycation end products and PTSD: molecular insights and dietary approaches for ne · 6/10 · Targeting AGE formation and enhancing endogenous deglycation mechanisms through pharmacological, nut
Rare diseases with high unmet need
No high-priority finds today (best candidate scored 6/10)
🟢⚪ STANDARD (4-7) — Top by Topic
Hematologic malignancies
• PM42646642 · Medial meniscus posterior root repair with concomitant centralization does not d · 7/10 · Public Health • PM42648700 · Epidemiological and clinical trends of malignant small-bowel tumors in Asia. · 6/10 · Early Detection • PM42645532 · Comparison of time to therapy initiation, therapeutic strategies and survival in · 6/10 · Other • PM42648786 · Oral mycosis fungoides. · 5/10 · Other
CBC-based diagnostics and machine learning in hematology
• PM42645391 · Deep Learning-Based Detection Model for Leukemia Cells in Peripheral Blood Smear · 5/10 · Diagnostics
Early cancer detection
• PM42645213 · Urine and Blood-Derived MicroRNAs in Patients with Kidney Cancer: A Review of Cl · 6/10 · Diagnostics
AI/ML in clinical diagnostics and imaging
• PM42648026 · A novel approach for liver steatosis assessment in ultrasound images using an ad · 7/10 · Other • PM42649122 · Noninvasive Profiling of the Glioma Vascular Microenvironment via 7T MRI: Decodi · 6/10 · Diagnostics • PM42648921 · Multiparametric MRI-Based Interpretable Machine Learning Radiomics Model for Pre · 6/10 · Diagnostics • PM42648596 · Association between body composition and recurrence in stage II-III colon cancer · 6/10 · Diagnostics • PM42648552 · Associations between human oxytocin receptor gene promoter DNA methylation and b · 6/10 · Genomics/Precision Medicine
Precision oncology and genomic medicine
• PM42648417 · Emerging Acylations in Malignancies: Molecular Mechanisms, Research Advances, an · 6/10 · Treatment Innovation • PM42645367 · Facility-Level Medical Oncology Specialist Availability and First-Line Time to T · 6/10 · Genomics/Precision Medicine • PM42648923 · Intratumoral Heterogeneity-aware Imaging Biomarkers for Bone Metastasis Risk Str · 5/10 · Diagnostics • PM42648415 · PARP Inhibitors and the Tumor Micro-environment: Bidirectional Crosstalk, Resist · 5/10 · Treatment Innovation
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
• PM42648751 · Pre-existing systemic immune state and dynamic myeloid remodeling shape response · 7/10 · Treatment Innovation • PM42647088 · Autocrine Control of CD276 by SPARC in Liver Cancer and Its Contribution to Immu · 5/10 · Treatment Innovation • PM42647623 · Cardiac tertiary immune niches drive immune activation in immune checkpoint inhi · 5/10 · Treatment Innovation • PM42648983 · UNITE® Technology: Translating lysosomal targeting vaccines for allergy therapy. · 5/10 · Treatment Innovation • PM42648907 · Proteomic landscape of pan-tissue neuroendocrine carcinomas defines subtype-spec · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
• PM42645635 · GLP-1 Receptor Agonists and Obesity Related Cancers: What We Know So Far. · 7/10 · Prevention • PM42644866 · Body Composition and Lifestyle Interventions in Pharmacological Treatment of Acq · 6/10 · Prevention • PM42644855 · From Guidelines to Clinical Practice: Expert Perspectives on Long-Term Managemen · 6/10 · Other • PM42647645 · IDE-mediated GLP-1 degradation as the basis for designing long-acting and CNS-st · 5/10 · Prevention • PM42647098 · Nonscarring Alopecia in Adults Treated With GLP-1s: A Propensity Score Matched T · 5/10 · Prevention
Aging, longevity, and population health
• PM42648826 · Multiplexed EDL-FET biosensor with tannic acid stabilization for simultaneous p- · 7/10 · Public Health • PM42646836 · Domain-Specific Cognitive Concordance in Older Married Couples. · 6/10 · Public Health • PM42648863 · Valve-In-Valve Transcatheter Aortic Valve Replacement: Advances in Planning, Tec · 5/10 · Diagnostics • PM42648719 · Astrocyte-Predominant Tau Pathology in a Patient With VCP R191Q Variant. · 5/10 · Diagnostics
Rare diseases with high unmet need
• PM42649076 · [Clinical practice and research of chronic inflammatory demyelinating polyneurop · 6/10 · Diagnostics • PM42648159 · Equity in genome sequencing for rare disease diagnosis: a cross-sectional analys · 6/10 · Genomics/Precision Medicine • PM42645872 · Imaging Cardiac Amyloidosis: From Early Diagnosis to Risk Stratification and Eva · 6/10 · Early Detection
📊 TODAY'S BREAKDOWN
- By research category: Treatment Innovation: 11, Diagnostics: 9, Prevention: 6, Other: 6, Early Detection: 6, Genomics/Precision Medicine: 4, Public Health: 3
- By evidence maturity: Exploratory: 45
- By source type: peer_reviewed 45 | preprint 0
- Topics with zero 8+ articles: CBC-based diagnostics and machine learning in hematology, Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk, Rare diseases with high unmet need
📊 By Watchlist Topic (reviewed / kept / highest score)
• Hematologic malignancies: 15 reviewed / 14 kept / best 8/10 • CBC-based diagnostics and machine learning in hematology: 1 reviewed / 1 kept / best 5/10 • Early cancer detection: 13 reviewed / 13 kept / best 9/10 • AI/ML in clinical diagnostics and imaging: 15 reviewed / 15 kept / best 7/10 • Precision oncology and genomic medicine: 8 reviewed / 8 kept / best 9/10 • Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 15 kept / best 8/10 • Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 12 kept / best 7/10 • Aging, longevity, and population health: 15 reviewed / 15 kept / best 7/10 • Rare diseases with high unmet need: 3 reviewed / 3 kept / best 6/10 • Sentinel Scan (unsolicited finds): 10 reviewed / 10 kept / best 7/10
🔧 RUN NOTES
- Window: CRDT 2026-08-26 09:15 → 2026-08-27 09:15, no expansion triggered (all topics returned ≥1 result)
- CBC/ML hematology (T2): only 1 result in window — inherently sparse; no fallback query needed (unique PMID 42492965, already in T1)
- Rare diseases (T9): 6 results in window, below 15-candidate cap — reviewed all 6
- Sentinel scan: capped at 10; unsolicited finds flagged
- Scoring: rule-based heuristic v1.3 (conservative); abstract-level classification
- Run status: SUCCESS