Daily digest · Fri · 28 Aug 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Rare diseases with high unmet need

[PMID42658855] · Expedited pathway portfolios, trial complexity, and FDA approval timelines in oncology and neurology · 10/10 · These findings support a pathway-evidence alignment framework rather than a simple model in which more expedited designa [PMID42650786] · SMAD4-BPIFA1 Axis Governs Airway Antiviral Defense in Myhre Syndrome. · 8/10 · Collectively, our findings establish that GOF SMAD4 signaling enhances viral vulnerability in airway epithelium through

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

[PMID42658188] · A Phase 1 First-Time-in-Human, Open-Label Study of Nelistotug Administered to Patients with Advanced · 9/10 · Nelistotug as monotherapy and in combination with dostarlimab and belrestotug had an acceptable safety and tolerability [PMID42657984] · Advances and future perspectives in the treatment of small cell lung cancer: From chemotherapy and r · 9/10 · We focused on the progress in the treatment modalities for SCLC and discussed future perspectives involving novel therap [PMID42658167] · Efficacy and safety of durvalumab with or without tremelimumab in the treatment of metastatic non-sm · 8/10 · Further prospective studies are needed to clarify the optimal role of CTLA-4 blockade in combination immunotherapy. [PMID42658220] · Liquid biopsy in solid tumours: expert opinion paper of the European society of pathology. · 6/10 · Incorporation of specific professional personal profiles (molecular biologists, bioinformaticians) to pathology laborato [PMID42658846] · Extracting adverse event nature, severity, timelines and resulting interventions from clinical notes · 6/10 · While cautious use of LLMs is warranted due to the variable performance observed in this study, these results support fu

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

[PMID42659612] · Anomaly Detection With an Expanded Standardized First-Trimester Fetal Anatomic Ultrasound Screening · 8/10 · As an expanded standardized screening framework incorporating additional first-trimester anatomic views, it improves ear [PMID42658660] · Osimertinib plus anlotinib in untreated, EGFR-mutated, advanced non-small-cell lung cancer with conc · 8/10 · org. cn). [PMID42658504] · HOTV Vision Test Compared With Tumbling E for Pediatric Vision Screening. · 8/10 · ClinicalTrials. gov Identifier: NCT05770661. [PMID42658220] · Liquid biopsy in solid tumours: expert opinion paper of the European society of pathology. · 6/10 · Incorporation of specific professional personal profiles (molecular biologists, bioinformaticians) to pathology laborato [PMID42659613] · Sexual and Gender Minorities' Experience with Cervical Cancer Screening: A Systematic Review of Qual · 5/10 · CINAHL, Embase, PubMed, Scopus, PsycINFO and ProQuest were searched. All studies were published in English between 1. [PMID42658498] · Rates of Never Receiving Cervical Cancer Screening Among US Women, 2005-2023. · 5/10 · This cross-sectional study examines trends in the prevalence of never having been screened for cervical cancer from 2005 [PMID42658442] · Clinical significance of combining circulating tumor DNA and endoscopic response evaluation for esop · 5/10 · These indicators will individualize ESCC treatment.

AI/ML in clinical diagnostics and imaging

[PMID42659419] · Artificial intelligence for the detection and diagnosis of oral and maxillofacial lesions: evidence, · 8/10 · While AI holds significant promise, its routine clinical implementation for oral diagnostic tasks remains premature, req [PMID42658364] · Perceived communication quality of a standardized neuroradiology report following AI-based simplific · 8/10 · Critical relevance statement In a standardized neuroradiology report, AI-based simplification improved perceived communi [PMID42657380] · Artificial Intelligence in Nuclear Medicine (2015-2025): Clinical Applications, Regulatory Governanc · 8/10 · Radiopharmacists should be actively involved in this process, particularly in relation to radiopharmaceutical quality, t

Precision oncology and genomic medicine

[PMID42658187] · A Phase 2 Basket Trial of Ado-Trastuzumab Emtansine for Patients with HER2 Amplified Cancers: A Non- · 8/10 · T-DM1 demonstrated heterogenous efficacy among HER2-amplified tumor types, with promising response and outcomes among pa [PMID42658167] · Efficacy and safety of durvalumab with or without tremelimumab in the treatment of metastatic non-sm · 8/10 · Further prospective studies are needed to clarify the optimal role of CTLA-4 blockade in combination immunotherapy. [PMID42658220] · Liquid biopsy in solid tumours: expert opinion paper of the European society of pathology. · 6/10 · Incorporation of specific professional personal profiles (molecular biologists, bioinformaticians) to pathology laborato

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

[PMID42658493] · Early Sodium-Glucose Cotransporter-2 Inhibitor Use After Acute Kidney Injury in Type 2 Diabetes. · 8/10 · These findings support timely initiation of SGLT-2 inhibitors during the post-AKI recovery period and provide a rational [PMID42658458] · Prediabetes: diagnostic aspects, clinical features, and emerging therapeutic opportunities, with a f · 8/10 · Current evidence supports consideration of vitamin D supplementation as a complementary intervention in selected high-ri

Aging, longevity, and population health

[PMID42654291] · Beyond Bone Health: Exploring the "Heart-Brain-Bone" Axis Modulated by Lipid-Soluble Nutrients (Omeg · 8/10 · Adequately powered factorial randomized controlled trials stratified by baseline Omega-3 index, 25(OH)D and vitamin K st

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

[PMID42659576] · Refined Continuous Risk Index for Accurately Predicting Outcomes of Patients With Chronic Lymphocyti · 7/10 · By introducing CIRI2-CLL, we offer a dynamic tool for investigators to reliably identify patients with increased risk of [PMID42658749] · Redefining Fitness in Chronic Lymphocytic Leukemia: A Treatment-Specific Framework forthe Targeted T · 7/10 · Most patients, including those with lower resilience, are candidates for targeted therapy; the clinical imperative is to

CBC-based diagnostics and machine learning in hematology

No high-priority finds today (best candidate scored 6/10)

🟢⚪ STANDARD (5-7) — Top by Topic

AI/ML in clinical diagnostics and imaging

[PMID42658839] · A clinical decision support tool for accurate hip fracture prediction: A nationwide cohort study. · 7/10 · Diagnostics [PMID42658447] · Introduction and validation of OSCAR-optimal stent choice algorithm. · 7/10 · Diagnostics [PMID42657627] · Morphometric Explanations for Deep Learning Based Neuroimaging Classifiers. · 7/10 · Diagnostics [PMID42659608] · Implementing America's AI Action Plan in Health Care: Impact on Student and Practice-Based EHR Educa · 6/10 · Diagnostics [PMID42659605] · Executive Nurse Leader-Clinical Nurse Scientist Partnership for AI in Nursing Practice. · 6/10 · Diagnostics

Precision oncology and genomic medicine

[PMID42659586] · Genomic Landscape of Metastatic Urothelial Cancer in a Multicenter Cohort From Argentina. · 7/10 · Diagnostics [PMID42658872] · HDAC2 restrains IGF2BP1-associated m6A dysregulation in cervical cancer immunotherapy resistance. · 7/10 · Treatment Innovation [PMID42658002] · Paired genomic profiling of primary tumor and lymph-node metastases identifies candidate prognostic · 7/10 · Diagnostics [PMID42658786] · Advancing Homologous Recombination Repair Mutation Testing in Prostate Cancer in Australia: Shifting · 6/10 · Treatment Innovation [PMID42658417] · Performance of dual-layer spectral CT-based extracellular volume fraction to assess Ki-67 proliferat · 6/10 · Treatment Innovation

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

[PMID42658872] · HDAC2 restrains IGF2BP1-associated m6A dysregulation in cervical cancer immunotherapy resistance. · 7/10 · Treatment Innovation [PMID42658729] · MRI of Hepatocellular Carcinoma: Cross-regional Perspectives on Trends and Opportunities. · 7/10 · Treatment Innovation [PMID42658691] · Structural basis and preclinical efficacy of MG1124, a novel CEACAM1-targeting antibody synergizing · 7/10 · Treatment Innovation [PMID42658562] · Biopsied Cutaneous Adverse Effects of PD-1 and PD-L1 Checkpoint Inhibitors and Progression-free Surv · 7/10 · Treatment Innovation [PMID42658417] · Performance of dual-layer spectral CT-based extracellular volume fraction to assess Ki-67 proliferat · 6/10 · Treatment Innovation

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

[PMID42658457] · Association between visceral adiposity index and metabolic dysfunction-associated steatotic liver di · 7/10 · Diagnostics [PMID42658392] · ⁠From liver to cardiovascular system: the MASLD-ASCVD continuum. · 7/10 · Treatment Innovation [PMID42659627] · Global Research Landscape on Leptin Resistance and Obesity-Related Metabolic Dysfunction: Trends, Ne · 6/10 · Diagnostics [PMID42658934] · SGLT2 inhibitors activate pantothenate kinase in the human heart. · 6/10 · Diagnostics [PMID42658742] · Investigating Atherosclerosis through Ultrasonographic Assessment of Carotid Intima-Media Thickness · 6/10 · Diagnostics

Rare diseases with high unmet need

[PMID42657756] · Clinical Variability and Genotype-Driven Outcomes in CHRND-Related Congenital Myasthenic Syndrome. · 7/10 · Treatment Innovation [PMID42658027] · AMCP Market Insights: Optimizing managed care approaches to treatment-resistant depression. · 5/10 · Treatment Innovation [PMID42655479] · Electrochemical Detection of SMN Protein by Immunosensors: The Role of Surface Modifications in Scre · 5/10 · Treatment Innovation [PMID42650028] · Epithelioid Sarcoma: A Review and Update. · 5/10 · Diagnostics [PMID42657439] · Synchronous retroperitoneal and mesenteric dedifferentiated liposarcoma: case report of a challengin · 4/10 · Treatment Innovation

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

[PMID42658923] · Incorporation of selinexor into conditioning regimens prior to allogeneic hematopoietic stem cell tr · 6/10 · Diagnostics [PMID42658759] · The introduction of hypomethylation agents and venetoclax into standard care for older patients with · 6/10 · Treatment Innovation [PMID42658505] · Cancer Biologics Utilization After Biosimilar Entry and Financial Implications For Payers and Patien · 6/10 · Treatment Innovation [PMID42658448] · [(18)F]FDG PET/CT role in FUO among patients with end-stage renal disease on renal replacement thera · 6/10 · Treatment Innovation [PMID42658760] · Genetic control of local mutation rates. · 5/10 · Genomics/Precision Medicine

CBC-based diagnostics and machine learning in hematology

[PMID42649810] · Smart Cardiac ICU: Digital Integration, Predictive Analytics, and Perioperative Inflammation. · 6/10 · Treatment Innovation

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

[PMID42658875] · Assessment of disability of leprosy in Bangladesh: A hospital-based study. · 6/10 · Early Detection [PMID42658853] · Impact of preanalytical variables on urinary cell-free DNA quality: Centrifugation, EDTA concentrati · 6/10 · Early Detection [PMID42658805] · Delayed diagnosis as a barrier to Zero Leprosy: Lived experiences from Pakistan. · 6/10 · Early Detection [PMID42658340] · tRNA-derived small RNAs in vascular smooth muscle cell phenotypic switching and vascular remodelling · 6/10 · Early Detection [PMID42657911] · Integrated microbiome and metabolome profiling in prepubertal girls with vulvar lichen sclerosus. · 6/10 · Early Detection

Aging, longevity, and population health

[PMID42658663] · Food Insecurity and Cardiovascular-Kidney-Metabolic Syndrome-Related Conditions Among US Adults, Nat · 6/10 · Diagnostics [PMID42659421] · More than a trend: the rationale for using bioactive materials in clinical practice. · 6/10 · Diagnostics [PMID42658821] · Household wealth is associated with child stunting but not wasting: Evidence from the 2024 Nigeria D · 6/10 · Diagnostics [PMID42656234] · Artificial intelligence-integrated multimodal retinal imaging for early detection and risk stratific · 6/10 · Early Detection [PMID42654284] · Vitamin C as a Potential Geroprotector: Interactions with Aging Hallmarks and Implications for Healt · 6/10 · Diagnostics

💡 UNSOLICITED FINDS

[PMID42659618] · Effectiveness of Educational Programmes on Knowledge and Practice Related to Diabetic Foot Care Amon · 8/10

📊 TODAY'S BREAKDOWN

By research category: Diagnostics: 39, Early Detection: 14, Genomics/Precision Medicine: 4, Other: 1, Public Health: 1, Treatment Innovation: 45
By evidence maturity: Exploratory: 68, Potentially Practice-Changing: 10, Validated: 26
By watchlist topic: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): reviewed=15, high=0, best_score=7 CBC-based diagnostics and machine learning in hematology: reviewed=5, high=0, best_score=6 Early cancer detection (liquid biopsy, ctDNA, cfDNA): reviewed=15, high=3, best_score=8 AI/ML in clinical diagnostics and imaging: reviewed=15, high=3, best_score=8 Precision oncology and genomic medicine: reviewed=15, high=2, best_score=8 Novel therapeutics: immunotherapy, CAR-T, targeted therapy: reviewed=15, high=3, best_score=9 Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: reviewed=15, high=2, best_score=8 Aging, longevity, and population health: reviewed=15, high=1, best_score=8 Rare diseases with high unmet need: reviewed=12, high=2, best_score=10 Sentinel scan: reviewed=10, high=1, best_score=8
By source type: peer_reviewed 104 | preprint 0
Topics with zero 8+ articles this run: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma), CBC-based diagnostics and machine learning in hematology

🔧 RUN NOTES

Clean run, no issues.