📅 PUBMED DAILY TRIAGE — 2026-08-31 Window: 2026-08-30T00:00:00Z → 2026-08-31T23:59:59Z (CRDT) Topics scanned: 10 | Articles reviewed: 84 | Candidates evaluated: 91 High priority: 10 | Standard: 37 | Low/archive: 0 | Unsolicited finds: 4 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
PMID:42669181 · CD74 in hematological malignancies: from MHC chaperone to therapeutic target. · 5/10 · Narrative review; relevance and evidence were scored conservatively from the PubMed abstract.
CBC-based diagnostics and machine learning in hematology
CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 6/10)
Early cancer detection
PMID:42668443 · Impact of methodological variability on the prognostic performance of circulating tumor DNA in colorectal cancer: A systematic review and meta-analysis. · 7/10 · Meta-analysis; relevance and evidence were scored conservatively from the PubMed abstract. PMID:42669262 · One-pot dual-toehold RCA-Cas12a biosensor driven by a preassembled three-arm toehold-gated DNA template for sequence-selective miRNA liquid biopsy. · 5/10 · Observational cohort study; relevance and evidence were scored conservatively from the PubMed abstract. PMID:42669321 · Molecular Mechanisms of Exosome-Mediated Drug Resistance in Central Nervous System Tumours. · 5/10 · Narrative review; relevance and evidence were scored conservatively from the PubMed abstract. PMID:42668624 · Serial Donor-derived Cell-free DNA Monitoring in a Kidney Transplant Recipient With Adenovirus Nephritis. · 4/10 · Case report; relevance and evidence were scored conservatively from the PubMed abstract.
AI/ML in clinical diagnostics and imaging
PMID:42669326 · Artificial intelligence in Latin American hepatology: current evidence, implementation barriers, and strategic priorities. · 8/10 · Randomized controlled trial; relevance and evidence were scored conservatively from the PubMed abstract.
Precision oncology and genomic medicine
Precision oncology and genomic medicine: No high-priority finds today (best candidate scored 5/10)
Novel therapeutics
PMID:42668627 · Advanced therapy medicinal products in Saudi Arabia: Regulation and development. · 5/10 · Narrative review; relevance and evidence were scored conservatively from the PubMed abstract. PMID:42669181 · CD74 in hematological malignancies: from MHC chaperone to therapeutic target. · 5/10 · Narrative review; relevance and evidence were scored conservatively from the PubMed abstract. PMID:42669369 · Targeting CARM1 impairs DNA damage repair and attenuates B-cell acute lymphoblastic leukemia progression. · 5/10 · Observational or experimental study; relevance and evidence were scored conservatively from the PubMed abstract. PMID:42669593 · CAR-Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune-Mediated Inflammation. · 4/10 · Narrative review; relevance and evidence were scored conservatively from the PubMed abstract.
Cardiovascular-metabolic
PMID:42669069 · Influence of Disease-Modifying Therapy on the Efficacy of Vutrisiran in Transthyretin Cardiac Amyloidosis. · 8/10 · Randomized controlled trial; relevance and evidence were scored conservatively from the PubMed abstract.
Aging, longevity, and population health
Aging, longevity, and population health: No high-priority finds today (best candidate scored 6/10)
Rare diseases with high unmet need
Rare diseases with high unmet need: No high-priority finds today (best candidate scored 6/10)
Sentinel scan
Sentinel scan: No high-priority finds today (best candidate scored 7/10)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
PMID:42669516 · [Prophylactic or pre-emptive therapy with azacitidine or FLT3 inhibitor after allogeneic hematopoietic stem cell transplantation for AML and MDS]. · 6/10 · Other PMID:42668494 · Comparative Efficacy of Herbal Products on Metabolic Parameters in Metabolic-Dysfunction Associated Liver Disease: A Systematic Review and Network Meta-Analysis. · 6/10 · Other PMID:42668697 · Timing of response in patients with relapsed/refractory FLT3 mut+ acute myeloid leukemia treated with gilteritinib. · 6/10 · Other PMID:42669182 · Hypereosinophilic syndrome and suspected myeloid neoplasia in relapsed Hodgkin lymphoma during immune checkpoint inhibitor therapy: a rare case. · 6/10 · Treatment Innovation PMID:42669517 · [Treatment landscape of mature NK/T-cell lymphomas: treatment outcomes in Japan and future prospects]. · 6/10 · Other
CBC-based diagnostics and machine learning in hematology
PMID:42669333 · Baseline Lymphocyte Count Outperforms Dosimetry and Inflammatory Markers for Predicting Severe Radiation-Induced Lymphopenia in Rectal Cancer. · 6/10 · Diagnostics
Early cancer detection
PMID:42669322 · Prognostic Models and Predictors of Recurrence in Resectable Colorectal Liver Metastases: A Systematic Review and Meta-analysis. · 7/10 · Diagnostics PMID:42669007 · Method Matters: A Proteomics-Informed Framework for Selecting Extracellular Vesicle Isolation Methods for Plasma. · 4/10 · Other PMID:42669214 · Application of aptamer nucleic acid test strips in the detection of tumor markers for colorectal cancer. · 4/10 · Other
AI/ML in clinical diagnostics and imaging
PMID:42668832 · Artificial intelligence-based ECG as a triage tool for acute myocardial infarction: a diagnostic systematic review and meta-analysis. · 7/10 · Diagnostics PMID:42669322 · Prognostic Models and Predictors of Recurrence in Resectable Colorectal Liver Metastases: A Systematic Review and Meta-analysis. · 7/10 · Diagnostics PMID:42669107 · Multi-omics, machine learning, and molecular simulation identify CD44 as a candidate target in endocrine-disrupting chemical-associated thyroid cancer progression. · 6/10 · Diagnostics PMID:42668808 · Identification and validation of novel platelet-related genes in ulcerative colitis using bioinformatics and machine learning strategies. · 6/10 · Diagnostics PMID:42669001 · An Interpretable MRI-Based Machine Learning Model for Preoperative Identification of the Vascular Dissemination Phenotype in Hepatocellular Carcinoma: A Dual-Center Study. · 6/10 · Diagnostics
Precision oncology and genomic medicine
PMID:42668807 · Dynamic precision therapy in chronic gastrointestinal diseases: A focus on gastroesophageal reflux disease and inflammatory bowel disease-A narrative review and conceptual perspective. · 5/10 · Genomics/Precision Medicine PMID:42669193 · Multi-Omic Analysis of Putative Cellular Senescence-Associated Genes on the Risk of Pan-Cancer. · 4/10 · Genomics/Precision Medicine PMID:42668898 · Systematic Analysis of Plasma-Derived Extracellular Vesicle-Enriched Samples in Age-Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles. · 4/10 · Genomics/Precision Medicine PMID:42668477 · PTC124 promotes mutation site-dependent readthrough of STK11 nonsense mutations and restores tumor suppressor function. · 4/10 · Genomics/Precision Medicine PMID:42668612 · Diagnostic and prognostic role of circular RNAs: Analytical challenges and emerging opportunities. · 4/10 · Genomics/Precision Medicine
Novel therapeutics
PMID:42668666 · Safety Evaluation of Tarlatamab in SCLC: A Systematic Review and Meta-Analysis. · 6/10 · Treatment Innovation PMID:42668473 · Comparison of surgical treatment versus transcatheter arterial chemoembolization combined with systemic treatment for spontaneously ruptured hepatocellular carcinoma. · 6/10 · Treatment Innovation PMID:42669182 · Hypereosinophilic syndrome and suspected myeloid neoplasia in relapsed Hodgkin lymphoma during immune checkpoint inhibitor therapy: a rare case. · 6/10 · Treatment Innovation PMID:42669342 · An Immune-Activated Co-culture Model of Patient-Derived Gastric Cancer Organoids and Peripheral Blood Mononuclear Cells for Personalized Chemotherapy Screening. · 6/10 · Treatment Innovation PMID:42669447 · [Impact of liver metastatic burden on prognosis of patients with pancreatic neuroendocrine tumor and liver metastases after radical resection]. · 6/10 · Treatment Innovation
Cardiovascular-metabolic
PMID:42669305 · Aetiology, management, and outcomes of acute heart failure in 17 African countries (THESUS-HF II): a prospective, multicentre, observational cohort study. · 7/10 · Other PMID:42669075 · Effect of In-Hospital Initiation of Dapagliflozin on Decongestion in Patients Hospitalized for Heart Failure: An Analysis of the DAPA ACT HF-TIMI 68 Trial. · 6/10 · Other PMID:42669304 · Adverse pregnancy outcomes and long-term cardiovascular disease risk. · 6/10 · Other PMID:42669566 · Cardiovascular disease burden at cancer diagnosis: temporal trends in a national study from England. · 6/10 · Other PMID:42668568 · SGLT2 inhibitor therapy is associated with IL-10/TGF-α/sVEGFR3 signalling and adipose tissue remodelling in advanced heart failure. · 5/10 · Other
Aging, longevity, and population health
PMID:42669523 · Insights from a workshop on climate-resilience in health systems in Japan and Germany: strategies to counteract social isolation and heat health risks for older adults. · 6/10 · Public Health PMID:42669491 · Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging. · 5/10 · Public Health PMID:42669197 · Prolonged brain cytokine elevation and microgliosis following exposure to World Trade Center dust particulate matter in male spontaneously hypertensive rats. · 4/10 · Public Health PMID:42669560 · Age-Related Changes in bis-Retinoids of Lipofuscin Granules in Human Retinal Pigment Epithelium Cells. · 4/10 · Public Health PMID:42669067 · SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin-Modifying Complexes. · 4/10 · Public Health
Rare diseases with high unmet need
PMID:42669517 · [Treatment landscape of mature NK/T-cell lymphomas: treatment outcomes in Japan and future prospects]. · 6/10 · Other PMID:42669034 · Estrogen-related receptor α promotes breast cancer cell migration and invasion by activating transforming growth factor β signaling. · 6/10 · Other
Sentinel scan
PMID:42668572 · Paraspinal muscle CT measurements in predicting subsequent fractures after percutaneous kyphoplasty in elderly women. · 7/10 · Other PMID:42668507 · Outcomes of partial vs. complete repair for large to massive rotator cuff tears: a systematic review and meta-analysis. · 6/10 · Other PMID:42669053 · Prognostic significance of systemic immunoinflammatory biomarkers and pathological features in clear cell renal cell carcinoma: a multicenter study. · 6/10 · Other PMID:42668613 · Pan-cancer analysis of Notch pathway-linked gene expression identifies tumour-specific and sex-stratified prognostic associations. · 6/10 · Other
💡 UNSOLICITED FINDS
📊 TODAY'S BREAKDOWN
- By research category: {'Diagnostics': 7, 'Other': 17, 'Early Detection': 4, 'Treatment Innovation': 9, 'Public Health': 5, 'Genomics/Precision Medicine': 5}
- By evidence maturity: {'Validated': 9, 'Exploratory': 38}
- By source type: {'peer_reviewed': 47}
- Topics with zero HIGH articles: CBC-based diagnostics and machine learning in hematology, Precision oncology and genomic medicine, Aging, longevity, and population health, Rare diseases with high unmet need, Sentinel scan
🔧 RUN NOTES
- 48-hour CRDT window applied.
- Full candidate coverage is recorded in Output A search logs.
- Raw result sets above the 15/10 caps were truncated after deterministic PubMed ordering.