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‹ Wed · 2 Sep 2026
Early cancer detection or prevention

Spleen stiffness measurement rules out high-risk varices in patients with chronic portal vein thrombosis without cirrhosis

A simple spleen ultrasound measurement can safely spare some patients unnecessary endoscopy for dangerous bleeding risk assessment.

This PubMed-indexed diagnostic validation study examines Spleen stiffness measurement rules out high-risk varices in patients with chronic portal vein thrombosis without cirrhosis. The available abstract reports Screening endoscopy can be spared in patients with compensated cirrhosis when spleen stiffness measurement (SSM) by vibration-controlled transient elastography (VCTE) is ≤40 kPa, as they have a low probability of high-risk varices (HRV) Conversely, endoscopy is required in all patients with chronic portal vein.

What the study was

Study design
Diagnostic validation study
Population
Human participants
Category
Early Detection
Maturity
Validated
Journal
Journal of hepatology

Why it surfaced

Conservative rapid triage: diagnostic validation study, human evidence, and direct relevance to Hematologic malignancies.

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