Conditioning Intensity and Outcomes in Pediatric HLA-Identical Transplant for Sickle Cell Disease: Comparison of MAC, RIC, and NMA.
This retrospective study examined Myeloablative conditioning (MAC) has been the conventional approach, but reduced-intensity conditioning (RIC) and nonmyeloablative conditioning (NMA) may achieve cure with less tox. Key finding: CONCLUSION: NMA conditioning with alemtuzumab and low-dose TBI substantially reduces toxicity compared with MAC and RIC.
This retrospective study examined Myeloablative conditioning (MAC) has been the conventional approach, but reduced-intensity conditioning (RIC) and nonmyeloablative conditioning (NMA) may achieve cure with less tox. Key finding: CONCLUSION: NMA conditioning with alemtuzumab and low-dose TBI substantially reduces toxicity compared with MAC and RIC.
What the study was
- Study design
- Retrospective study
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Transplantation and cellular therapy
Why it surfaced
High-priority retrospective study in Rare diseases with high unmet need.
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