Daily digest · Thu · 10 Sep 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

PMID:42716509 · Initial Diagnosis of Hematologic Malignancies Identified Through Thyroid Fine-Needle Aspiration. · 4/10 · Retained because its case report evidence is relevant to Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma); Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata.

CBC-based diagnostics and machine learning in hematology

CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 0/10)

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

PMID:42715505 · Personalized Circulating Tumor DNA Analysis for Predicting Outcomes and Tracking Response to Radiotherapy and Pembrolizumab in Localized Sarcomas: Analysis of the SU2C-SARC032 Trial. · 8/10 · Retained because its randomized controlled trial evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42715513 · Risk-Adapted Optimization of Neoadjuvant Therapy in Human Epidermal Growth Factor Receptor 2-Positive Early-Stage Breast Cancer. · 8/10 · Retained because its randomized controlled trial evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42716838 · Prognostic Value of Androgen Receptor (AR) Gene Alterations Detected in Circulating Tumor DNA (ctDNA) in Patients With Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Meta-analysis. · 8/10 · Retained because its meta-analysis evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42712798 · Prognostic Value of Circulating Tumor DNA (ctDNA) in Diffuse Large B-Cell Lymphoma (DLBCL): Systematic Review and Meta-Analysis. · 7/10 · Retained because its meta-analysis evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42713037 · Circulating tumor DNA-based minimal residual disease-guided adjuvant therapy in solid tumors: Current evidence, clinical trial frameworks, and future directions. · 7/10 · Retained because its randomized controlled trial evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42713197 · Organ preservation after neoadjuvant immunotherapy in mismatch repair-deficient colorectal cancer: response assessment, watch-and-wait, and salvage surgery. · 7/10 · Retained because its randomized controlled trial evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42713910 · Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision. · 7/10 · Retained because its randomized controlled trial evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42715861 · Circulating tumor DNA and recurrence after curative-intent treatment of hepatocellular carcinoma: A systematic review and meta-analysis. · 7/10 · Retained because its meta-analysis evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42715227 · Uncovering the diagnostic potential of seminal fluid beyond fertility: cfDNA methylation analysis for the detection of clinically significant prostate cancer. · 6/10 · Retained because its observational cohort study evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42715508 · Prospective Evaluation of Circulating Tumor DNA in Metastatic Hormone-Sensitive Prostate Cancer. · 6/10 · Retained because its observational cohort study evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42716240 · Phage-based biosensors for Cancer biomarker detection and diagnosis. · 6/10 · Retained because its review evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42714248 · Pre-operative circulating tumour DNA in high-risk primary cutaneous melanoma: prospective feasibility in molecular pathology. · 5/10 · Retained because its observational cohort study evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42716872 · [Oncogenetics and molecular tumor boards in private practice: Specificities and perspectives]. · 5/10 · Retained because its observational or exploratory study evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata. PMID:42711582 · Systemic metastases in a BRAF V600E-mutant pleomorphic xanthoastrocytoma classified by DNA methylation: treatment with BRAF/MEK inhibitors and liquid biopsy monitoring. · 3/10 · Retained because its case report evidence is relevant to Early cancer detection (liquid biopsy, ctDNA, cfDNA); scoring is conservative for the available metadata.

AI/ML in clinical diagnostics and imaging

AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate scored 7/10)

Precision oncology and genomic medicine

PMID:42711696 · Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors. · 8/10 · Retained because its meta-analysis evidence is relevant to Precision oncology and genomic medicine; scoring is conservative for the available metadata. PMID:42715123 · Engagement and Retention in Precision Public Health: A Cascade Analysis of Two Cluster Randomized Trials. · 8/10 · Retained because its randomized controlled trial evidence is relevant to Precision oncology and genomic medicine; scoring is conservative for the available metadata.

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

PMID:42712808 · Therapeutic Potential of High Dose Vitamin C in Cancer: Mechanisms, Clinical Evidence and Future Directions. · 8/10 · Retained because its systematic review evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42716474 · Risk Stratification in Non-Muscle-Invasive Bladder Cancer in the Era of Expanding Therapeutic Options: Are Current Classifications Still Adequate? · 8/10 · Retained because its randomized controlled trial evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42715563 · Treatment Decisions in Multiple Myeloma. · 6/10 · Retained because its review evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42716420 · Revisiting tumor vasculature in the era of cancer immunotherapy: from aberrant hallmark to therapeutic target. · 6/10 · Retained because its review evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42716532 · CART-Cell Therapy in Pediatric Acute Lymphoblastic Leukemia: A Review for General Pediatricians. · 6/10 · Retained because its review evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42716382 · Sarcomatoid malignancies with strong PD-L1 expression often represent dedifferentiated or undifferentiated melanomas. · 5/10 · Retained because its observational cohort study evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42716706 · PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype. · 5/10 · Retained because its observational cohort study evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42716890 · Immunotherapy in the critically ill cancer patient: What the intensivist should know. · 5/10 · Retained because its observational or exploratory study evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42714310 · Sintilimab‑related cystitis/ureteritis in high‑grade endometrial stromal sarcoma: A case report and structured literature review. · 4/10 · Retained because its case report evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42715308 · Spatiotemporal mapping of tertiary lymphoid structure heterogeneity shapes immune niches and clinical outcomes in intrahepatic cholangiocarcinoma. · 4/10 · Retained because its observational or exploratory study evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42715334 · TCR-JANUS engager proteins enable bispecific targeting to overcome tumor heterogeneity in TCR-T cell therapy. · 4/10 · Retained because its preclinical experimental study evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42715496 · Daratumumab Treatment in Severe Anti-NMDAR Encephalitis: Two Case Reports and Literature Review. · 4/10 · Retained because its case report evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42716509 · Initial Diagnosis of Hematologic Malignancies Identified Through Thyroid Fine-Needle Aspiration. · 4/10 · Retained because its case report evidence is relevant to Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma); Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42716692 · 18 F-FDG PET/CT-visualised immune-related hepatitis after immune checkpoint inhibitor combination treatment in a patient with metastatic melanoma. · 4/10 · Retained because its case report evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata. PMID:42715569 · Complete Regression of Hepatoblastoma after Interleukin-15- and Interleukin-21-Coexpressing CAR T-Cell Therapy. · 3/10 · Retained because its observational or exploratory study evidence is relevant to Novel therapeutics: immunotherapy, CAR-T, targeted therapy; scoring is conservative for the available metadata.

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

PMID:42714458 · Tirzepatide and the Incidence of Atrial Fibrillation in Adults With Overweight or Obesity: An Updated Meta-Analysis of Randomized Controlled Trials. · 8/10 · Retained because its randomized controlled trial evidence is relevant to Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk; scoring is conservative for the available metadata.

Aging, longevity, and population health

Aging, longevity, and population health: No high-priority finds today (best candidate scored 7/10)

Rare diseases with high unmet need

Rare diseases with high unmet need: No high-priority finds today (best candidate scored 6/10)

Sentinel scan

Sentinel scan: No high-priority finds today (best candidate scored 7/10)

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

PMID:42712970 · Simultaneous DOTATATE uptake in three non-neuroendocrine pathologies: Follicular lymphoma, Crohn's disease, and vertebral hemangioma. · 7/10 · Treatment Innovation PMID:42716724 · Long-Term Outcomes After Elective Splenectomy for Haematological Disease: A 27-Year Single-Centre Study. · 7/10 · Treatment Innovation PMID:42716866 · Transcatheter vs Surgical Replacement of Degenerated Bioprosthetic Aortic Valve: A Meta-Analysis of Propensity-Score-Matched Studies. · 7/10 · Treatment Innovation

CBC-based diagnostics and machine learning in hematology

No retained standard finds.

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

No retained standard finds.

AI/ML in clinical diagnostics and imaging

PMID:42716465 · Brain cancer in silico modelling - the roadmap ahead. · 7/10 · Diagnostics PMID:42716230 · MicroRNAs in polyglutamine diseases: Mechanistic insights, circulating biomarkers, and emerging microRNA-based therapeutic strategies. · 6/10 · Diagnostics PMID:42716711 · MRI Radiomics for Survival Prediction in Brain Metastases: A Machine Learning Analysis. · 6/10 · Diagnostics

Precision oncology and genomic medicine

PMID:42712839 · Coumarins at the Crossroads of Drug Development: Enzyme Modulation for Clinical Advances. · 7/10 · Genomics/Precision Medicine PMID:42716205 · Effector-cell-engaging bispecific antibodies for cancer therapeutics: engineering precision immunity. · 7/10 · Genomics/Precision Medicine PMID:42712222 · Obesity-driven adipokine signaling in breast cancer: mechanistic insights, therapeutic challenges, and opportunities for precision oncology. · 6/10 · Genomics/Precision Medicine

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

No retained standard finds.

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

PMID:42714656 · Therapeutics candidates and repurposing strategies to target parkinson's disease pathology: current evidence and future directions. · 7/10 · Prevention PMID:42712258 · Global prevalence and associated factors of metabolic syndrome in patients with systemic lupus erythematosus: A systematic review and meta-analysis. · 6/10 · Prevention PMID:42714692 · Beyond the Liver: Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) Associated 35% Higher Risk of Clinically Diagnosed Heart Failure With Preserved Ejection Fraction (HFpEF). · 6/10 · Prevention

Aging, longevity, and population health

PMID:42713229 · Fenofibrate in ophthalmology: therapeutic efficacy and mechanisms. · 7/10 · Public Health PMID:42711697 · Aging while caregiving: a life course qualitative study of left-behind older parents caring for adult children with schizophrenia in rural China. · 6/10 · Public Health PMID:42711726 · Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases. · 6/10 · Public Health

Rare diseases with high unmet need

PMID:42714046 · Genetic Determinants of Early Heart Failure in Hypoplastic Left Heart Syndrome: A Prospective NC-DEFINE Study. · 6/10 · Other PMID:42716676 · Discordance between disease activity and long-term outcomes in DNASE1L3 deficiency: a multicentre longitudinal cohort study. · 6/10 · Other PMID:42715344 · Proteomics identify disease-associated variants in patients with rare diseases undiagnosed after genome sequencing. · 5/10 · Other

💡 UNSOLICITED FINDS

PMID:42711755 · Frontline therapies for adult patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia: a systematic literature review. · 7/10 PMID:42712115 · Ultrasound-guided botulinum toxin injection in patients with chronic plantar fasciitis: comparison of plantar fascia origin injection and the babcock method-a randomized controlled trial. · 6/10 PMID:42713255 · Utilization of intubation kits and checklist to improve first-pass success and reduce complications associated with endotracheal intubation in Rwanda. · 6/10

📊 TODAY'S BREAKDOWN

By research category: {"Genomics/Precision Medicine":5,"Treatment Innovation":18,"Prevention":4,"Early Detection":14,"Other":6,"Public Health":3,"Diagnostics":3}
By evidence maturity: {"Validated":25,"Exploratory":28}
By watchlist topic: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma) 15/4/7; CBC-based diagnostics and machine learning in hematology 0/0/0; Early cancer detection (liquid biopsy, ctDNA, cfDNA) 14/14/8; AI/ML in clinical diagnostics and imaging 15/3/7; Precision oncology and genomic medicine 15/5/8; Novel therapeutics: immunotherapy, CAR-T, targeted therapy 15/15/8; Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk 15/4/8; Aging, longevity, and population health 15/3/7; Rare diseases with high unmet need 3/3/6; Sentinel scan 10/0/7
By source type: peer_reviewed 53 | preprint 0
Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology; AI/ML in clinical diagnostics and imaging; Aging, longevity, and population health; Rare diseases with high unmet need

🔧 RUN NOTES

No window expansion was required because the initial search produced more than five relevant records.
High-volume searches were capped and logged; all selected PMIDs were requested in five-record metadata and abstract chunks.
CBC/ML primary and fallback queries both returned zero records.