Serum human epididymis protein 4 and long-term mortality in U.S. women: a nationally representative cohort study.
A blood protein linked to ovarian cancer also predicts long-term mortality in general women, broadening its potential use in cancer screening programs.
Using nationally representative NHANES data, this study demonstrates that serum HE4 is a prognostic biomarker for long-term mortality in the general female population, independent of cancer status. The finding broadens HE4's clinical relevance from gynecologic oncology to population-level risk stratification and potentially ovarian cancer screening contexts.
What the study was
- Study design
- Nationally representative cross-sectional study (NHANES)
- Population
- Adult US women (nationally representative, NHANES)
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Clinics (Sao Paulo, Brazil)
Why it surfaced
Nationally representative data repositioning HE4 as a population mortality biomarker beyond gynecologic oncology; strong study design with direct public health implications.
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