📅 PUBMED DAILY TRIAGE — 2026-09-12 Window: 2026-09-11T09:00:00Z → 2026-09-12T09:00:00Z (CRDT) Topics scanned: 9 watchlist + 1 sentinel | Articles reviewed: 122 candidates | Candidates evaluated: 49 High priority: 27 | Standard: 22 | Low/archive: 0 | Unsolicited finds: 3 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic Malignancies
- 42727844 · Cost-Effectiveness of Cilta-cel in Lenalidomide-Refractory Multiple Myeloma: An Analysis o... · 9/10 🟠 NOVEL_TREATMENT Phase III cost-effectiveness data for a transformative CAR-T therapy in relapsed/refractory multiple myeloma
- 42726724 · FACIT-fatigue score and treatment quality assessment for paroxysmal nocturnal hemoglobinur... · 9/10 🟡 UNDERSERVED_POPULATION Multicenter evidence gap for patient-reported outcomes in PNH, an ultra-rare blood disease where fatigue is the dominant
- 42727020 · Peripheral Blasts at Apheresis as a Risk Factor for Survival following Tisagenlecleucel in... · 8/10 🟠 NOVEL_TREATMENT Clinically actionable predictor for CAR-T outcome in pediatric B-ALL
Early Cancer Detection / Liquid Biopsy
- 42727049 · Evaluation of a Tumor-Informed Molecular Residual Disease Assay in Early Triple-Negative B... · 9/10 🔴 EARLY_CANCER_DETECTION Validated ctDNA MRD assay in early TNBC—one of the highest-need breast cancer subtypes—with direct implications for adju
- 42726930 · Recurrence and Circulating Tumor DNA in Human Papillomavirus-Positive Oropharyngeal Cancer... · 8/10 🔴 EARLY_CANCER_DETECTION Meta-analysis supporting ctDNA as a near-implementable surveillance biomarker in HPV+ oropharyngeal cancer
- 42725339 · Endoscopic Collection and Analysis of Gastric Fluid DNA: A Liquid Biopsy Methodology for T... · 8/10 🔴 EARLY_CANCER_DETECTION _Novel tumor-proximal liquid biopsy source (gastric fluid DNA) for a high-mortality cancer with critical early-detection _
- 42724868 · Circulating tumor DNA clearance as a trial-level early efficacy signal in solid tumors: a ... · 8/10 🔴 EARLY_CANCER_DETECTION Trial-level validation of ctDNA clearance as a surrogate efficacy endpoint with broad applicability across solid tumors
- 42724581 · Epigenetic profiling of circulating cell-free DNA for early detection and minimal residual... · 8/10 🔴 EARLY_CANCER_DETECTION Comprehensive synthesis of cfDNA epigenomics for lung cancer early detection
- 42726150 · DNA methylation biomarkers for early detection of ovarian cancer. · 7/10 🔴 EARLY_CANCER_DETECTION Comprehensive review of cfDNA methylation biomarkers for the hardest-to-detect gynecological cancer
AI/ML in Clinical Diagnostics
- 42727648 · Predicting Conversion from Mild Cognitive Impairment to Alzheimer's Disease: A Systematic ... · 9/10 🟢 NEAR_TERM_IMPLEMENTABLE Systematic review of ML-based early AD prediction with validated performance
- 42728197 · Artificial Intelligence Enables Nonexperts to Automatically Capture Lung Ultrasound Clips ... · 8/10 🟢 NEAR_TERM_IMPLEMENTABLE AI-enabled democratization of lung ultrasound for non-experts with validated clinical performance
- 42728183 · Microwave-Based Breast Density Assessment Using the SAFE Device. · 8/10 🟢 NEAR_TERM_IMPLEMENTABLE Novel radiation-free device for breast density assessment with validated performance
Precision Oncology & Genomics
- 42728193 · Long-term safety of first-line osimertinib plus platinum-pemetrexed in EGFR-mutated advanc... · 9/10 🟠 NOVEL_TREATMENT Long-term safety confirmation for the FLAURA2 regimen—a Phase III-validated first-line combination in EGFR NSCLC
- 42727421 · Clinically actionable genomic alterations in breast cancer brain metastases. · 8/10 🟠 NOVEL_TREATMENT Actionable genomic profiling data in BCBM, one of the highest-unmet-need settings in breast cancer
- 42727538 · Serum human epididymis protein 4 and long-term mortality in U.S. women: a nationally repre... · 8/10 ⬜ NONE Nationally representative data repositioning HE4 as a population mortality biomarker beyond gynecologic oncology
- 42727269 · Major salivary gland carcinomas: A 21-center cohort study of 892 patients with external va... · 8/10 🟡 UNDERSERVED_POPULATION Largest externally validated cohort for rare salivary gland carcinomas
- 42727566 · Pancreatic ductal adenocarcinoma: Clinical trials to watch. · 8/10 🟠 NOVEL_TREATMENT Landmark review of precision oncology trials entering PDAC—historically the deadliest major cancer—with directly monitor
- 42727892 · Antibody-drug conjugates in treatment-resistant hepatocellular carcinoma: mechanistic insi... · 8/10 🟠 NOVEL_TREATMENT Systematic review of ADCs in ICI-refractory HCC—an unmet need with rapidly growing evidence base
- 42727894 · Antibody therapeutics: A new era for EGFR-mutant NSCLC treatment. · 8/10 🟠 NOVEL_TREATMENT Timely review of antibody therapeutics redefining EGFR+ NSCLC management
Novel Therapeutics
- 42727637 · Safety and antitumor activity of the first-in-class EGFR-HER3 bispecific antibody-drug con... · 10/10 🟠 NOVEL_TREATMENT First-in-class EGFR-HER3 bispecific ADC with Phase 1b clinical evidence of activity in heavily pretreated solid tumors
Cardiovascular-Metabolic
- 42728029 · International expert panel review for the use of resmetirom and semaglutide in the managem... · 9/10 🟠 NOVEL_TREATMENT First expert guidance on two newly FDA-approved MASH therapies covering 6M+ affected US patients
- 42727859 · Effectiveness of non-pharmacological interventions on metabolic control in adults with typ... · 8/10 🟢 NEAR_TERM_IMPLEMENTABLE Meta-analysis providing strong evidence for non-pharmacological T2DM management
- 42727299 · A composite tool for predicting gestational diabetes or hypertensive disorders of pregnanc... · 8/10 🟢 NEAR_TERM_IMPLEMENTABLE Validated composite prediction tool for GDM/HDP with near-term clinical implementation potential
Aging & Longevity
- 42728062 · Deprescribing statins for adults 65 years of age and older: Evidence-based clinical practi... · 9/10 🟢 NEAR_TERM_IMPLEMENTABLE First evidence-based deprescribing guideline for statins in elderly
- 42726290 · Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer's vuln... · 9/10 ⚪ PROMISING_PRELIMINARY Novel molecular mechanism linking APOE risk and neuromelanin in earliest-affected Alzheimer's brain region
Rare Diseases
- 42725622 · Proteomic-guided targeted treatment of leukoencephalopathy with calcification and cysts. · 9/10 🟠 NOVEL_TREATMENT First proteomics-guided precision treatment for an ultra-rare neurological disease with no prior therapeutic options
Sentinel (Unsolicited)
- 42728198 · Comparative effectiveness and safety of carotid endarterectomy, carotid stenting, and opti... · 9/10 🟢 NEAR_TERM_IMPLEMENTABLE Contemporary comparative effectiveness data for carotid stenosis management
Topics with no HIGH-priority finds today: CBC/ML Hematology
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic Malignancies
- 42727885 · Mutational Landscape and Clonal Dynamics in AML Undergoing PTCy Hematopoietic Cell Tr... · 7/10 · Genomics/Precision Medicine
- 42727046 · Latin American Consensus for the Diagnosis, Staging, and Treatment of Peripheral T-Ce... · 7/10 · Treatment Innovation
- 42727556 · Marine microplastic pollution and cancer incidence from 2013 to 2021 in US coastal co... · 7/10 · Public Health
- 42728133 · Pulmonary Complications in Acute Myelogenous Leukemia in the Post-Allogeneic Hematopo... · 5/10 · Treatment Innovation
CBC/ML Hematology
- 42724116 · Development and validation of a multivariate predictive model for the risk of refract... · 5/10 · Diagnostics
Early Cancer Detection / Liquid Biopsy
- 42727690 · The effect of unique molecular identifier family size using tumor-informed circulatin... · 7/10 · Early Detection
- 42727325 · Long-read discovery in cancer cell lines defines a cis-spliced fusion RNA panel and i... · 7/10 · Early Detection
- 42727528 · Artificial intelligence for brain cancer management: multimodal digital workflows for... · 7/10 · Diagnostics
AI/ML in Clinical Diagnostics
- 42727989 · Evolving landscape of paediatric sepsis: progress, gaps and the next generation of to... · 7/10 · Diagnostics
- 42727595 · Assessing consciousness by near-nerve electrostimulation in intensive rehabilitation. · 7/10 · Diagnostics
Precision Oncology & Genomics
- 42727162 · Prognostic role of thymidine kinase 1 activity in hormone receptor positive metastati... · 6/10 · Diagnostics
Novel Therapeutics
- 42727656 · Transcriptional and epigenetic regulation of ferroptosis in cancer drug resistance: M... · 6/10 · Drug Development
- 42727848 · Genetic and biochemical screens identify MGAT1 as a druggable glycosyltransferase tar... · 5/10 · Drug Development
Cardiovascular-Metabolic
- 42727502 · Impact of post-recurrent pregnancy loss depression and anxiety on subsequent live bir... · 7/10 · Mental Health
- 42727867 · Where the Future Lies: GLP-1 Receptor Agonists as Therapeutics for Dermatologic Comor... · 6/10 · Treatment Innovation
Aging & Longevity
- 42727032 · Burden of malignant melanoma among the elderly population in East Asia from 1990 to 2... · 7/10 · Public Health
- 42726908 · Spaced retrieval practice improves the uptake of and intention to use personal neurop... · 7/10 · Other
- 42726849 · Ex vivo bone marrow subniches influence the fate of human antibody-secreting cells. · 7/10 · Other
Rare Diseases
- 42727654 · A novel pipeline for the validation of manganese chelators for the treatment of manga... · 5/10 · Drug Development
- 42724849 · Monocarboxylate transporter 1 deficiency: a rare case report and systematic review of... · 4/10 · Genomics/Precision Medicine
Sentinel (Unsolicited)
- 42728212 · Population pharmacokinetic/pharmacodynamic modeling of NH600001 reveals age-related d... · 6/10 · Drug Development
- 42728195 · The effect on back pain and fatigue level of acupressure after coronary angiography: ... · 6/10 · Treatment Innovation
💡 UNSOLICITED FINDS
- 42728198 · Comparative effectiveness and safety of carotid endarterectomy, carotid stenting, and opti · 9/10 Contemporary comparative effectiveness data for carotid stenosis management; directly informs practice debate between revascularization and optimal me
📊 TODAY'S BREAKDOWN
By research category:
- Treatment Innovation: 15
- Diagnostics: 10
- Early Detection: 8
- Genomics/Precision Medicine: 4
- Drug Development: 4
- Public Health: 3
- Other: 3
- Prevention: 1
- Mental Health: 1
By evidence maturity:
- Exploratory: 25
- Validated: 17
- Potentially Practice-Changing: 7
By watchlist topic (reviewed / HIGH / best score):
- Hematologic Malignancies: 15 reviewed | 1 HIGH | best score 9/10
- CBC/ML Hematology: 1 reviewed | 0 HIGH | best score 5/10
- Early Cancer Detection / Liquid Biopsy: 15 reviewed | 6 HIGH | best score 9/10
- AI/ML in Clinical Diagnostics: 15 reviewed | 3 HIGH | best score 9/10
- Precision Oncology & Genomics: 15 reviewed | 6 HIGH | best score 8/10
- Novel Therapeutics: 15 reviewed | 4 HIGH | best score 10/10
- Cardiovascular-Metabolic: 15 reviewed | 3 HIGH | best score 9/10
- Aging & Longevity: 15 reviewed | 2 HIGH | best score 9/10
- Rare Diseases: 6 reviewed | 2 HIGH | best score 9/10
- Sentinel (Unsolicited): 10 reviewed | 3 HIGH | best score 9/10
By source type:
- peer_reviewed: 49
Topics with zero HIGH-priority articles: CBC/ML Hematology
🔧 RUN NOTES
- Window: CRDT 2026-09-11T09:00:00Z → 2026-09-12T09:00:00Z (24h incremental; no window expansion triggered)
- T2 CBC/ML Hematology: Only 1 candidate returned for this topic in the 24h window. Hemorrhage/hematoma exclusions applied per task prompt v1.3 refinement. No fallback query triggered (1 candidate > 0 threshold).
- T6 Novel Therapeutics: 132 raw results; capped at 15 candidates per protocol. High volume dominated by immunotherapy/ADC papers.
- Sentinel scan: 1,025 raw results; capped at 10 candidates per protocol. 2 sentinel articles overlapped watchlist topics (42728193: FLAURA2, 42728197: AI LUS).
- All 112 unique candidate PMIDs fetched via esummary + efetch; 109/112 had full abstracts. 3 no-abstract records classified from title/metadata with classification_confidence=low.
- High deduplication: PMID 42727528 (AI brain cancer review) appears in T3/T4/T5 — assigned primary to T4; PMID 42726930 and 42727325 appear in T3/T5 — assigned primary to T3.
- No previous 2026-09-11 fingerprints overlap detected with today's PMIDs (all new CRDT entries).
- Attempt 1 of 3. Run ID: pubmed-triage-2026-09-12-attempt1-20260912T090000Z