Daily digest · Sun · 13 Sep 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Hematologic malignancies

42731241 · Relapse and progression after CAR-T cell therapy in large B-cell lymphoma: Patterns, mechanisms, and salvage strategies · 5/10 · Retained for Hematologic malignancies, Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need.

CBC-based diagnostics and machine learning in hematology

CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 4/10)

Early cancer detection

42730833 · Overcoming cancer resistance in pancreatic cancer: toward dynamic precision oncology · 5/10 · Retained for Early cancer detection, Precision oncology and genomic medicine; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42730986 · Quantifying HER-2 for Precision Oncology: The Role of Optical Biosensors · 5/10 · Retained for Early cancer detection, Precision oncology and genomic medicine; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731132 · A versatile biointerface with multiply flexible spatial molecular layers for improving tumor cell isolation and detection · 4/10 · Retained for Early cancer detection; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need.

AI/ML in clinical diagnostics and imaging

Precision oncology and genomic medicine

Novel therapeutics

42730913 · Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi-Omics and Machine Learning · 6/10 · Retained for AI/ML in clinical diagnostics and imaging, Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731732 · Incidence, Risk factors, and Outcomes of Thromboembolism in Patients with Melanoma Receiving Immune Checkpoint Inhibitors, Chemotherapy, or Targeted Therapy: a SEER-Medicare Analysis · 6/10 · Retained for Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731877 · Tumor cell-expressed OX40L enhances the efficacy of PD-1 axis blockade in non-small cell lung cancer · 6/10 · Retained for Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731878 · Deep learning-based CT model for non-invasive prediction of tertiary lymphoid structures in pancreatic cancer: a multicenter study with prospective validation in an immunochemotherapy cohort · 6/10 · Retained for Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731241 · Relapse and progression after CAR-T cell therapy in large B-cell lymphoma: Patterns, mechanisms, and salvage strategies · 5/10 · Retained for Hematologic malignancies, Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731419 · Role of CircRNA_0005075 in gastric cancer immune evasion through regulation of lactate metabolic reprogramming and histone lactylation · 5/10 · Retained for Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731467 · HSPA1A promotes immune-evasive colorectal liver metastasis through post-transcriptional stabilization of APP mRNA · 5/10 · Retained for Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731463 · Neuroimmune crosstalk in pancreatic ductal adenocarcinoma: integrating neuroscience and immuno-oncology · 4/10 · Retained for Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731891 · Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide-HLA complex · 4/10 · Retained for Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need. 42731875 · PLP1-triggered NOT gate to address neurotoxicity risk of PSMA-targeted prostate cancer therapy · 3/10 · Retained for Novel therapeutics; score reflects the available PubMed abstract, study design, clinical relevance, and unmet need.

Cardiovascular-metabolic

Cardiovascular-metabolic: No high-priority finds today (best candidate scored 7/10)

Aging, longevity, and population health

Aging, longevity, and population health: No high-priority finds today (best candidate scored 6/10)

Rare diseases with high unmet need

Rare diseases with high unmet need: No high-priority finds today (best candidate scored 6/10)

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic malignancies

42731102 · The Germline SH2B3(rs111340708) Splicing Variant Drives Intron Retention and Protein Instability by Impacting Clinical Outcomes in Core Binding Factor AML · 7/10 · Treatment Innovation 42731103 · Age-Stratified Conditioning Regimens for Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Myelodysplastic Syndromes: A Comprehensive Review · 7/10 · Treatment Innovation 42731821 · Distinguishing Cardiac Sarcomas From Lymphomas: Comparative Insights From Clinical and Echocardiographic Characteristics · 7/10 · Treatment Innovation 42731572 · Ultrasound-assisted extraction of polyphenols from Moutan Cortex using natural deep eutectic solvent: Optimization, molecular mechanisms, and lipid-lowering activity · 6/10 · Treatment Innovation 42730787 · Axial-tremor imbalance as a clinical marker for distinguishing progressive supranuclear palsy from Parkinson's disease · 5/10 · Treatment Innovation

AI/ML in clinical diagnostics and imaging

42731775 · Effect of Lossy JPEG Compression on AI Diagnostic Output Stability in Panoramic Radiograph Analysis · 7/10 · Diagnostics 42730927 · Development and evaluation of a deep learning model for computer-aided diagnosis of neonatal pneumothorax on chest radiographs · 6/10 · Diagnostics 42730964 · Multi-habitat radiomics on T2-FS MRI for identifying spatial patterns of axial spondyloarthritis-associated bone marrow edema · 6/10 · Diagnostics 42731011 · Exploring novel and evolved tools in atopic dermatitis diagnosis · 6/10 · Diagnostics

Precision oncology and genomic medicine

42731022 · A therapeutic atlas of monogenic inflammatory bowel disease · 7/10 · Genomics/Precision Medicine 42730802 · PROTAC as a Potential Toolbox for the Discovery of New Targets and Drugs · 6/10 · Genomics/Precision Medicine 42730883 · Mitochondrial Function-Related Genes in Sleep Disorders: A Multi-Omics Mendelian Randomization Study · 6/10 · Genomics/Precision Medicine 42731085 · Post-Translational Modifications in Traumatic Brain Injury: Decoding the Proteomic Landscape and Molecular Mechanisms of Secondary Injury · 6/10 · Genomics/Precision Medicine 42731348 · Futibatinib after non-covalent FGFR inhibitors in FGFR2-rearranged intrahepatic cholangiocarcinoma: clinical activity and resistance patterns · 6/10 · Genomics/Precision Medicine

Novel therapeutics

42731605 · Immune Checkpoint Inhibition in Locally Advanced, Recurrent, and Metastatic Cutaneous Squamous Cell Carcinoma · 7/10 · Treatment Innovation

Cardiovascular-metabolic

42730799 · Clinical Physiology of SGLT2 Inhibitors in Non-diabetic and Diabetic Individuals · 7/10 · Prevention 42730809 · SGLT2 Inhibitors as Potential Agents for Prevention, Treatment, and/or Improved Recovery from Acute Kidney Injury · 7/10 · Prevention 42731885 · Long-term association of the triglyceride-glucose index with cardiovascular involvement in systemic lupus erythematosus: a retrospective cohort study · 6/10 · Prevention 42730804 · Clinical Evidence of Cardioprotective Effects of SGLT2 Inhibitors · 5/10 · Prevention 42730846 · Optimising Exercise Prescription: A Meta-Analysis Examining the Dose Response of Exercise Duration on Cardiorespiratory Fitness Following HIIT and MICT · 5/10 · Prevention

Aging, longevity, and population health

42731842 · Engaging community to co-design a multilevel intervention to reduce lung cancer disparities in persistent poverty tracts in California through group model building and simulation · 6/10 · Public Health 42731816 · Suboptimal Echocardiographic Image Quality Predicts in-Hospital Mortality Across the Adult Age Spectrum, Independent of Admission Type: A Large-Scale NLP Study · 5/10 · Public Health

Rare diseases with high unmet need

42731850 · Rare Cause of Infantile Respiratory Distress: A Case Report of Lobar Hyperinflation in a Kenyan Neonate · 6/10 · Other 42731937 · Advancing clinical trials for rare renal cell carcinoma subtypes: Consensus statements from the International Kidney Cancer Symposium North America 2025 think tank · 6/10 · Other

💡 UNSOLICITED FINDS

None.

📊 TODAY'S BREAKDOWN

By research category: Diagnostics 4, Early Detection 3, Genomics/Precision Medicine 5, Other 4, Prevention 5, Public Health 2, Treatment Innovation 16
By evidence maturity: Exploratory 36, Validated 3
By watchlist topic: Hematologic malignancies: 12 reviewed / 6 kept / highest 7; CBC-based diagnostics and machine learning in hematology: 1 reviewed / 0 kept / highest 4; Early cancer detection: 3 reviewed / 3 kept / highest 5; AI/ML in clinical diagnostics and imaging: 15 reviewed / 5 kept / highest 7; Precision oncology and genomic medicine: 12 reviewed / 7 kept / highest 7; Novel therapeutics: 15 reviewed / 11 kept / highest 7; Cardiovascular-metabolic: 10 reviewed / 5 kept / highest 7; Aging, longevity, and population health: 2 reviewed / 2 kept / highest 6; Rare diseases with high unmet need: 2 reviewed / 2 kept / highest 6; Sentinel scan: 10 reviewed / 6 kept / highest 7
By source type: peer_reviewed 39 | preprint 0
Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology, Cardiovascular-metabolic, Aging, longevity, and population health, Rare diseases with high unmet need

🔧 RUN NOTES

Daily window did not require expansion.
Candidate caps were applied and logged; all selected PMIDs were accounted for.