📅 PUBMED DAILY TRIAGE — 2026-09-16 Window: 2026-09-15T00:00:00Z → 2026-09-16T09:14:47Z (CRDT) Topics scanned: 10 | Articles reviewed: 134 | Candidates evaluated: 134 High priority: 22 | Standard: 85 | Low/archive: 5 | Unsolicited finds: 8 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Precision oncology and genomic medicine
[PMID42743822] · Clinicopathological characteristics of giant cell tumor of bone and identification of a novel H3F3A · 9/10 · Further multicenter and functional studies are required to clarify the biological characteristics of this novel variant. [PMID42744526] · Systemic therapy for HCC: Doublets, triplets and beyond. · 8/10 · This review summarises current systemic therapies for advanced stages of HCC and discusses emerging strategies and bioma [PMID42743886] · Circulating free bacterial DNA as a novel biomarker for monitoring therapy response in patients with · 8/10 · These findings suggest therapy-specific host-microbiome-tumor interactions and warrant prospective validation. NCT021251 [PMID42743769] · Genomic profiling by circulating tumor DNA in patients with hormone receptor-positive/HER2-negative · 7/10 · Plasma NGS identified clinically meaningful ESR1 mutation rates across both contexts, supporting guideline-endorsed plas [PMID42743887] · Longitudinal analysis of circulating tumor DNA and CA19-9 dynamics in predicting disease relapse and · 6/10 · These findings support a dual-biomarker longitudinal monitoring framework as a practical, individualized approach to pos
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
[PMID42744764] · Survival Outcomes With Cadonilimab Versus PD-(L)1 Therapy in Front-Line Gastric Cancer: A Network Me · 9/10 · These results highlight the importance of selecting appropriate ICIs to optimize outcomes. [PMID42744526] · Systemic therapy for HCC: Doublets, triplets and beyond. · 8/10 · This review summarises current systemic therapies for advanced stages of HCC and discusses emerging strategies and bioma [PMID42743900] · Survival After Irreversible Electroporation in Unresectable Locally Advanced Pancreatic Cancer: A Me · 8/10 · The results of current study support the rationale for conducting future randomized trials in this setting and provide a [PMID42744523] · Liver transplantation for primary liver cancers in the era of transplant oncology. · 6/10 · Emerging biomarkers, including circulating tumour DNA, circulating tumour cells, and microRNAs, have the potential to im
Rare diseases with high unmet need
[PMID42742451] · Real-world treatment patterns and outcomes in metastatic clear cell renal cell carcinoma following i · 9/10 · There is high unmet need for novel therapies in the post-ICI setting.
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
[PMID42743820] · Treatment of acute myeloid leukemia with inv(3) or t(3;3): A single-center retrospective cohort stud · 8/10 · Novel strategies are needed to improve response durability and long-term outcomes in MECOM-rearranged AML. [PMID42742817] · Robotic assistance in total hip arthroplasty: a systematic review and meta-analysis of leg length, c · 8/10 · The limited number of studies, predominance of nonrandomized designs, and marked heterogeneity in some analyses temper t [PMID42742782] · Chidamide plus venetoclax as effective and safe maintenance therapy in high-risk acute myeloid leuke · 8/10 · In conclusion, CHI plus VEN as post-transplant maintenance therapy shows encouraging efficacy and a manageable safety pr
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
[PMID42743896] · Screening effectiveness and diagnostic gaps in early-onset colorectal cancer: A systematic review. · 8/10 · Future screening strategies should incorporate individualized risk assessment, earlier recognition of alarm symptoms, an [PMID42743769] · Genomic profiling by circulating tumor DNA in patients with hormone receptor-positive/HER2-negative · 7/10 · Plasma NGS identified clinically meaningful ESR1 mutation rates across both contexts, supporting guideline-endorsed plas [PMID42744412] · Participant views of case finding for COPD after lung cancer screening: the C FIND COPD study. · 6/10 · Interviewees were grateful for the service and aside from some practical aspects, people supported a wider roll-out. [PMID42744380] · Pilot feasibility study to deliver low-dose CT lung cancer screening in Scotland: descriptive findin · 6/10 · Further research should evaluate long-term outcomes, cost-effectiveness and strategies to improve equitable participatio [PMID42743887] · Longitudinal analysis of circulating tumor DNA and CA19-9 dynamics in predicting disease relapse and · 6/10 · These findings support a dual-biomarker longitudinal monitoring framework as a practical, individualized approach to pos [PMID42743455] · Circulating Tumor DNA Profiling Defines Risk Classification in Patients With Ewing Sarcoma: A Report · 6/10 · Risk groups that integrate ctDNA burden with clinical-molecular features differentiate patients with low-, intermediate- [PMID42744367] · Adherence to follow-up cervical cancer screening and its predictors among women living with HIV in M · 5/10 · Strengthening recall systems particularly in public and outreach facilities and implementing targeted interventions for
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
[PMID42743915] · Lactation as a targeted intervention for hypertensive disorders in pregnancy: understanding the card · 8/10 · Recognizing lactation as a component of preventive cardiology offers an important opportunity to reduce the long-term bu [PMID42743759] · Combination of genetic eNOS deficiency and high-fat diet induces reproducible cardiometabolic HFpEF. · 8/10 · This model can be readily adopted for the investigation of mechanistic insights into HFpEF pathobiology and for the stud
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate scored 3/10)
AI/ML in clinical diagnostics and imaging
No high-priority finds today (best candidate scored 7/10)
Aging, longevity, and population health
No high-priority finds today (best candidate scored 7/10)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
[PMID42744121] · Platelet-Rich Plasma Provides Greater Pain Relief and Functional Improvement Than Hyaluronic Acid fo · 7/10 · Treatment Innovation [PMID42743998] · Aggressive Cytotoxic Lymphomas of the Auricle: An Under-recognized Presentation. · 7/10 · Treatment Innovation [PMID42744202] · B-cell maturation antigen -targeted Tirapazamine-loaded liposomes overcome hypoxia-induced drug resi · 6/10 · Treatment Innovation [PMID42742967] · Stabilization of the PP2A-B56α complex overcomes venetoclax-azacitidine resistance by impairing OXPH · 6/10 · Treatment Innovation [PMID42744199] · Metal-organic framework-based Z-scheme heterostructure enables oxygen-independent sonodynamic immuno · 5/10 · Treatment Innovation
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
[PMID42744522] · Advances in the imaging of liver cancer. · 7/10 · Early Detection [PMID42744413] · High prevalence of coxsackievirus B antibodies in patients with cardiac sarcoidosis: a retrospective · 7/10 · Early Detection [PMID42743817] · Machine learning-driven analysis of CMV-DNA levels and associated factors. · 6/10 · Early Detection [PMID42743784] · Effects of supraclavicular radiotherapy on carotid arteries in breast cancer patients. · 6/10 · Early Detection [PMID42743620] · Early motor behavior reflects neurologic involvement in infants with congenital heart disease. · 6/10 · Treatment Innovation
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
[PMID42744522] · Advances in the imaging of liver cancer. · 7/10 · Early Detection [PMID42744697] · hPSC models in cancer mechanisms and therapeutic discovery. · 7/10 · Treatment Innovation [PMID42744131] · Lipid Metabolic Reprogramming in Colorectal Cancer: A Central Hub Integrating Diet, Microenvironment · 7/10 · Treatment Innovation [PMID42744037] · Modulation of Ferroptosis Bridges Radiotherapy and Immunotherapy to Improve Cancer Treatment Outcome · 7/10 · Treatment Innovation [PMID42744133] · Biomarker-Guided Treatment Selection in Metastatic Colorectal Cancer: A Critical Review of Establish · 6/10 · Treatment Innovation
AI/ML in clinical diagnostics and imaging
[PMID42744256] · Impact of Clinician-Recorded ACR TI-RADS Features on ChatGPT-5.4-Based Thyroid Nodule Classification · 7/10 · Diagnostics [PMID42743353] · Census-based adolescent depression risk assessment: A novel method and reflections. · 7/10 · Diagnostics [PMID42743854] · EA-DualGAT: An error-aware dual-graph attention framework for Parkinson's disease diagnosis from wea · 6/10 · Diagnostics [PMID42743545] · AI Agents for Multimodal Oncology Diagnosis: Toward Transparent and Traceable Clinical Decision Supp · 6/10 · Diagnostics [PMID42743322] · Evaluation of six different tests for Schistosoma haematobium diagnosis in a near-elimination settin · 6/10 · Diagnostics
Precision oncology and genomic medicine
[PMID42744697] · hPSC models in cancer mechanisms and therapeutic discovery. · 7/10 · Treatment Innovation [PMID42744123] · Advances in single-cell and spatial multi-omics for deciphering the mechanisms of pan-organ metastas · 7/10 · Treatment Innovation [PMID42743659] · Multi-omics and experimental validation identify RAPGEF2 as a protective prognostic biomarker in cle · 7/10 · Treatment Innovation [PMID42744693] · Challenges of Using Circulating Tumour DNA: Insights from Advanced Prostate Cancer. · 6/10 · Treatment Innovation [PMID42744133] · Biomarker-Guided Treatment Selection in Metastatic Colorectal Cancer: A Critical Review of Establish · 6/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
[PMID42744726] · A multicenter real-world study on the safety and effectiveness of the glucagon-like peptide-1 recept · 7/10 · Treatment Innovation [PMID42744528] · Estimated vascular age using the Framingham model as a predictor of metabolic syndrome in a large co · 7/10 · Prevention [PMID42744018] · Estimated cumulative LDL-C exposure and risk of recurrent cardiovascular events after acute coronary · 7/10 · Diagnostics [PMID42743770] · Racial and ethnic disparities in metabolic syndrome care among prostate cancer patients on androgen · 7/10 · Treatment Innovation [PMID42744082] · Efficacy and safety of avexitide for treatment of hypoglycemia following bariatric and other upper g · 6/10 · Treatment Innovation
Aging, longevity, and population health
[PMID42744572] · US Trends in Lacking a Personal Doctor, by Educational Attainment, 2016-2023. · 7/10 · Diagnostics [PMID42743203] · Preparing for the future: A mixed methods study protocol on AI awareness and educational integration · 6/10 · Diagnostics [PMID42744597] · Aquaporin 3 Promoter Polymorphisms Reduce Gene Expression and Associate Altered Autophagy-Related Ge · 6/10 · Diagnostics [PMID42744574] · Impact of a Primary Care Value-Based Compensation Model. · 6/10 · Diagnostics [PMID42744447] · Advancing competency-based education in nursing: Faculty-driven innovation for transforming populati · 6/10 · Diagnostics
Rare diseases with high unmet need
[PMID42742480] · Creutzfeldt-Jakob Disease in the Era of Diagnostic Triumph and Therapeutic Defeat: A Perspective fro · 7/10 · Treatment Innovation [PMID42742155] · Atypical hemolytic uremic syndrome in kidney transplantation. · 7/10 · Treatment Innovation [PMID42740902] · New treatments in myositis on the horizon. · 7/10 · Treatment Innovation [PMID42740840] · An Additional Criterion to Appraisal of Guidelines for Research and Evaluation II Might Increase the · 7/10 · Diagnostics [PMID42740838] · Guidelines or Other Guidance Documents for Rare Diseases in the Netherlands: When and Where to Inves · 7/10 · Diagnostics
💡 UNSOLICITED FINDS
[PMID42744691] · Dosimetric and therapeutic effectiveness of high-dose-rate radionuclide sources in breast cancer bra · 8/10 [PMID42744536] · Novel patient-level social determinants of health measure predicts colon cancer outcomes within an i · 8/10 [PMID42744531] · Behavior change techniques to improve treatment adherence in type 2 diabetes: A systematic review. · 8/10
📊 TODAY'S BREAKDOWN
- By research category: Diagnostics: 40, Early Detection: 14, Genomics/Precision Medicine: 1, Other: 3, Prevention: 2, Treatment Innovation: 52
- By evidence maturity: Exploratory: 74, Potentially Practice-Changing: 9, Validated: 29
- By watchlist topic: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): reviewed=15, high=3, best_score=8 CBC-based diagnostics and machine learning in hematology: reviewed=4, high=0, best_score=3 Early cancer detection (liquid biopsy, ctDNA, cfDNA): reviewed=15, high=1, best_score=8 AI/ML in clinical diagnostics and imaging: reviewed=15, high=0, best_score=7 Precision oncology and genomic medicine: reviewed=15, high=3, best_score=9 Novel therapeutics: immunotherapy, CAR-T, targeted therapy: reviewed=15, high=3, best_score=9 Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: reviewed=15, high=2, best_score=8 Aging, longevity, and population health: reviewed=15, high=0, best_score=7 Rare diseases with high unmet need: reviewed=15, high=1, best_score=9 Sentinel scan: reviewed=10, high=3, best_score=9
- By source type: peer_reviewed 112 | preprint 0
- Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology, AI/ML in clinical diagnostics and imaging, Aging, longevity, and population health
🔧 RUN NOTES
- Clean run, no issues.