📅 PUBMED DAILY TRIAGE — 2026-09-17 Window: 2026-09-16T09:14:47Z → 2026-09-17T09:14:22Z (CRDT) Topics scanned: 10 | Articles retained: 51 | Candidates evaluated: 122 High priority: 15 | Standard: 36 | Low/archive: 0 | Unsolicited finds: 5 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+ or qualifying flag) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
PMID:42748353 · Beta Testing an mHealth Symptom Management Intervention for People With Advanced Cancer: Single-Cohort Feasibility and Acceptability Study. · 8/10 · Randomized controlled trial with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749050 · Final Biomarker and Efficacy Analyses of Lorlatinib in Patients With ALK-Positive Advanced Non-Small Cell Lung Cancer in a Phase 2 Study. · 8/10 · Phase 2 clinical trial with human evidence; scored conservatively from PubMed abstract-level metadata.
CBC-based diagnostics and machine learning in hematology
CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 0/10)
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
PMID:42749050 · Final Biomarker and Efficacy Analyses of Lorlatinib in Patients With ALK-Positive Advanced Non-Small Cell Lung Cancer in a Phase 2 Study. · 8/10 · Phase 2 clinical trial with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749185 · Diagnostic accuracy of menstrual blood for human papillomavirus detection in cervical cancer screening: A systematic review and meta-analysis. · 8/10 · Randomized controlled trial with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749187 · CytoHPV: Assessment of the predictive value of cytological analysis in relation to colposcopy-guided histology, before and after use of the primary HPV test. · 6/10 · Observational or descriptive study with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749606 · Prostate Cancer Screening: The Population Benefit Outweighs the Harm (Pro). · 6/10 · Observational or descriptive study with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42746454 · Endometrial Carcinoma Unveiling Breast Carcinoma in a Postmenopausal Female: A Case of Synchronous Malignancy. · 4/10 · Case report with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749540 · Liquid biopsy in glioblastoma: emerging technologies and translational opportunities. · 3/10 · Narrative review with unknown evidence; scored conservatively from PubMed abstract-level metadata. PMID:42748384 · Bridging the Gap: From Molecular Residual Disease to Curative Opportunity: Circulating Tumor DNA-Guided Surveillance After Curative Resection for Stage I to III Colorectal Cancer. · 2/10 · Observational or descriptive study with unknown evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749242 · Evolutionary genomics, tumor dynamics, and mathematical modeling of cancer progression: Implications for precision oncology. · 2/10 · Study protocol with unknown evidence; scored conservatively from PubMed abstract-level metadata.
AI/ML in clinical diagnostics and imaging
AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate scored 7/10)
Precision oncology and genomic medicine
PMID:42745950 · Stratifying lung adenocarcinoma: a novel prognostic model based on mitochondrial outer membrane permeabilization activity. · 8/10 · Cohort study with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749050 · Final Biomarker and Efficacy Analyses of Lorlatinib in Patients With ALK-Positive Advanced Non-Small Cell Lung Cancer in a Phase 2 Study. · 8/10 · Phase 2 clinical trial with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749540 · Liquid biopsy in glioblastoma: emerging technologies and translational opportunities. · 3/10 · Narrative review with unknown evidence; scored conservatively from PubMed abstract-level metadata. PMID:42749242 · Evolutionary genomics, tumor dynamics, and mathematical modeling of cancer progression: Implications for precision oncology. · 2/10 · Study protocol with unknown evidence; scored conservatively from PubMed abstract-level metadata.
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
PMID:42748921 · Chemotherapy-free phase 1/2 trial of HRS-4642 plus adebrelimab in previously treated metastatic KRAS G12D-mutant pancreatic cancer. · 8/10 · Phase 2 clinical trial with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42748428 · Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia. · 7/10 · Randomized controlled trial with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42748509 · Pembrolizumab plus chemotherapy as first-line therapy for advanced HER2-negative gastric or gastroesophageal junction adenocarcinoma: 4.5-year follow-up from the randomized phase III KEYNOTE-859 study. · 7/10 · Phase 3 clinical trial with human evidence; scored conservatively from PubMed abstract-level metadata. PMID:42748914 · Single-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance. · 7/10 · Clinical trial with mixed evidence; scored conservatively from PubMed abstract-level metadata.
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: No high-priority finds today (best candidate scored 7/10)
Aging, longevity, and population health
Aging, longevity, and population health: No high-priority finds today (best candidate scored 7/10)
Rare diseases with high unmet need
Rare diseases with high unmet need: No high-priority finds today (best candidate scored 7/10)
Sentinel scan
PMID:42745683 · Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in elderly patients undergoing non-cardiac and non-neurosurgical procedures: protocol for a multicentre, double-blind, randomized, controlled trial. · 8/10 · Randomized controlled trial with human evidence; scored conservatively from PubMed abstract-level metadata.
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
PMID:42747869 · A hemoglobin >120g/L trends toward improved survival without increasing vascular events in ESA-treated MDS patients. · 7/10 · Treatment Innovation PMID:42747872 · T-cell dynamics, CD8/NK ratio and tumor survival hallmarks determine response to T-cell bispecific forimtamig in myeloma. · 7/10 · Treatment Innovation PMID:42748967 · The European Landscape of Breast Implant-Associated Anaplastic Large Cell Lymphoma: Reporting, Surveillance, and Management Practices from the European Society of Plastic, Reconstructive and Aesthetic Surgery Survey 2026. · 6/10 · Genomics/Precision Medicine PMID:42749465 · Impact of Vincristine Dose Reduction on Outcomes of Patients With Advanced-Stage Diffuse Large B-Cell Lymphoma Treated With R-CHOP. · 6/10 · Treatment Innovation
CBC-based diagnostics and machine learning in hematology
No retained standard-priority articles.
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
PMID:42749376 · National trends, variation and short-term outcomes in surgery for non-small cell lung cancer in England, 2015-2023: a population-based cohort study using linked national cancer registration and hospital administrative data. · 7/10 · Diagnostics PMID:42748904 · Cell-Free DNA Screening After Euploid Embryo Transfer: Concordance With Amniocentesis and Residual Aneuploidy Risk. · 6/10 · Early Detection PMID:42746640 · Prestin as a context-dependent biomarker of outer hair cell stress: Integrating preclinical and clinical evidence. · 5/10 · Early Detection PMID:42748261 · Renal-clearable fluorescent probe for early detection of pancreatic cancer in living murine models. · 5/10 · Early Detection
AI/ML in clinical diagnostics and imaging
PMID:42747586 · Identification and Validation of a Lactylation-Related Gene Expression Signature for Diagnosis of Acute Ischemic Stroke. · 7/10 · Diagnostics PMID:42747635 · ECG-based artificial intelligence for obstructive sleep apnea detection: a mechanism-oriented diagnostic meta-analysis. · 7/10 · Diagnostics PMID:42748492 · Prediction Models for In-Hospital Delirium Using Routinely Collected Electronic Health Record Data: Systematic Review. · 7/10 · Diagnostics PMID:42748856 · Radiomics and its application to neuro-oncology: A narrative review of advances, clinical application and implementation challenges. · 7/10 · Diagnostics
Precision oncology and genomic medicine
PMID:42748508 · Zolbetuximab plus chemotherapy versus immune checkpoint inhibitor regimens by programmed death-ligand 1 combined positive score in locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma: a Bayesian network meta-analysis. · 7/10 · Genomics/Precision Medicine PMID:42748896 · Accelerating discovery: Transformative clinical trial models in neuro-oncology. · 7/10 · Genomics/Precision Medicine PMID:42747208 · Relating transcriptomics to protein abundance reveals self-driven versus interactor-driven proteins. · 6/10 · Genomics/Precision Medicine PMID:42749153 · TISON: A Web Server for Omics-driven Integrative Cancer Modeling & Simulations towards Personalized Medicine. · 6/10 · Genomics/Precision Medicine PMID:42749361 · Longitudinal gut microbiome dynamics during immunotherapy identify microbial features of clinical benefit in advanced primary liver cancer. · 6/10 · Treatment Innovation
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
PMID:42748801 · Management of hepatocellular carcinoma in older patients - An overview. · 6/10 · Treatment Innovation PMID:42749361 · Longitudinal gut microbiome dynamics during immunotherapy identify microbial features of clinical benefit in advanced primary liver cancer. · 6/10 · Treatment Innovation PMID:42749578 · Dendritic cells as programmable platforms for cancer immunotherapy. · 6/10 · Treatment Innovation PMID:42748971 · [Molecular Diagnostics and Personalized Therapy for Metastatic Castration-Resistant Prostate Cancer (mCRPC)]. · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
PMID:42748409 · Mild alkaline phosphatase elevation associates with increased mortality and major adverse liver outcomes in MASLD. · 7/10 · Public Health PMID:42749086 · Persistent C-reactive protein elevation and incident heart failure in adults at increased cardiovascular risk: A multinational electronic health record study. · 7/10 · Public Health PMID:42748745 · Objective and Subjective Multidimensional Sleep Health in Women After Myocardial Infarction. · 6/10 · Public Health PMID:42748919 · Plasma proteins are integral to cross-tissue gene regulatory networks implicated in cardiometabolic disorders and coronary artery disease. · 6/10 · Public Health
Aging, longevity, and population health
PMID:42748460 · Efficacy and Effectiveness of the Recombinant Zoster Vaccine Against Herpes Zoster, Herpes Zoster Ophthalmicus, Postherpetic Neuralgia and Dementia: A Systematic Review and Meta-Analysis. · 7/10 · Public Health PMID:42747379 · Integrating Leg-Press Strength and Nutritional Status Improves 16-Year Mortality Risk Stratification in General Older Adults. · 6/10 · Public Health PMID:42747574 · Climate-associated burden of chronic kidney disease due to non-optimal temperature in G20 countries: evidence from a multicountry longitudinal study. · 6/10 · Public Health PMID:42747622 · Balance Between Order and Disorder: Quantum-Epigenetic Pathways for the Emergence and Continuous Evolution of Life. · 6/10 · Public Health
Rare diseases with high unmet need
PMID:42749089 · NAA10 and NAA15 Mutations in Cardiovascular Disorders: Recent Advances and Mechanistic Insights. · 7/10 · Other PMID:42745568 · Preparing Genetic Counselors for Advocacy Partnerships: A Novel Internship Model. · 6/10 · Other PMID:42748922 · H3K27M drives OPC stemness and intrathecal therapeutic vulnerability in brainstem glioma organoids. · 6/10 · Drug Development PMID:42745576 · Caring for Rare Genetic Disease: A Vision for the Future. · 5/10 · Drug Development
Sentinel scan
PMID:42745658 · Opioid-free analgesia with esketamine-dexmedetomidine versus opioid-based analgesia after gynaecological laparoscopic surgery: a double-blind, randomized, controlled trial. · 7/10 · Public Health PMID:42746826 · AutoPathNet: a patient-specific automated 3D trajectory planning framework for minimally invasive evacuation of hypertensive intracerebral hemorrhage. · 6/10 · Diagnostics PMID:42746934 · How equity in cancer services has been defined and measured, and why it matters: a scoping review of Universal Health Coverage systems. · 6/10 · Public Health PMID:42746589 · Food preference learning strategies for toddlers with high food fussiness: A pilot study. · 5/10 · Public Health
💡 UNSOLICITED FINDS
PMID:42745683 · Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in elderly patients undergoing non-cardiac and non-neurosurgical procedures: protocol for a multicentre, double-blind, randomized, controlled trial. · 8/10 · Public Health PMID:42745658 · Opioid-free analgesia with esketamine-dexmedetomidine versus opioid-based analgesia after gynaecological laparoscopic surgery: a double-blind, randomized, controlled trial. · 7/10 · Public Health PMID:42746826 · AutoPathNet: a patient-specific automated 3D trajectory planning framework for minimally invasive evacuation of hypertensive intracerebral hemorrhage. · 6/10 · Diagnostics PMID:42746934 · How equity in cancer services has been defined and measured, and why it matters: a scoping review of Universal Health Coverage systems. · 6/10 · Public Health PMID:42746589 · Food preference learning strategies for toddlers with high food fussiness: A pilot study. · 5/10 · Public Health
📊 TODAY'S BREAKDOWN
- By research category: Diagnostics 6, Drug Development 2, Early Detection 10, Genomics/Precision Medicine 6, Other 2, Public Health 13, Treatment Innovation 12
- By evidence maturity: Exploratory 39, Validated 12
- By watchlist topic:
- Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 15 reviewed / 6 kept / highest 8
- CBC-based diagnostics and machine learning in hematology: 0 reviewed / 0 kept / highest 0
- Early cancer detection (liquid biopsy, ctDNA, cfDNA): 15 reviewed / 12 kept / highest 8
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 4 kept / highest 7
- Precision oncology and genomic medicine: 15 reviewed / 10 kept / highest 8
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 8 kept / highest 8
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 4 kept / highest 7
- Aging, longevity, and population health: 15 reviewed / 4 kept / highest 7
- Rare diseases with high unmet need: 7 reviewed / 4 kept / highest 7
- Sentinel scan: 10 reviewed / 5 kept / highest 8
- By source type: peer_reviewed 51 | preprint 0
- Topics with zero HIGH articles this run: CBC-based diagnostics and machine learning in hematology, AI/ML in clinical diagnostics and imaging, Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk, Aging, longevity, and population health, Rare diseases with high unmet need
🔧 RUN NOTES
- PubMed CRDT date query covered 2026-09-16 through 2026-09-17.
- CBC/ML hematology primary and mandated fallback queries both returned zero candidates.
- Candidate retrieval was capped at 15 per watchlist topic and 10 for the sentinel; all selected PMIDs were fetched and reviewed.
- Full text was not reviewed; classifications and summaries use PubMed abstracts and citation metadata.