📅 PUBMED DAILY TRIAGE — 2026-09-18 Window: 2026-09-17T09:31:00Z → 2026-09-18T09:31:00Z (CRDT) Topics scanned: 10 | Articles reviewed: 38 | Candidates evaluated: 119 High priority: 7 | Standard: 31 | Low/archive: 6 | Unsolicited finds: 4 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
Hematologic malignancies: No high-priority finds today (best candidate scored 7/10).
CBC-based diagnostics and machine learning in hematology
CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 0/10).
Early cancer detection
42750936 · Implementing multimodal liquid biopsy in glioblastoma: A prospective feasibility study of a standardized clinical workflow. · 8/10 · The proposed workflow provides a reproducible foundation for larger studies aimed at advancing clinical implementation of liquid biopsy strategies 42751026 · Phenotype-driven cascade screening in a Syrian family with clinically consistent multiple endocrine neoplasia type 2A. · 4/10 · This family highlights the value of phenotype-driven cascade screening when rearranged during transfection (RET) proto-oncogene testing is unavailable and emphasizes the importance 42752242 · Invited Commentary: Pancreatic Cancer Screening and Early Detection: Current Perspectives and Future Opportunity. · 3/10 · No abstract was available, so the finding was classified from the title and citation metadata for Invited Commentary: Pancreatic Cancer Screening and Early Detection: Current Persp
AI/ML in clinical diagnostics and imaging
AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate scored 6/10).
Precision oncology and genomic medicine
Precision oncology and genomic medicine: No high-priority finds today (best candidate scored 8/10).
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42754263 · Pre-existing immunity and hrHPV status determine immunotherapy response in advanced penile cancer: biomarkers and overall survival in the PERICLES trial. · 8/10 · Interrogation of the penile cancer immune microenvironment highlights CD8+PD1+ T-cells as candidate biomarkers in relation to clinical benefit from immune checkpoint blockade in ad 42750728 · SKYSCRAPER-05: A Phase 2 Study of Perioperative Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Patients With Previously Untreated, Locally Advanced, Resectable, Stage II‒IIIB NSCLC. · 6/10 · Perioperative tiragolumab combined with atezolizumab ± chemotherapy proved to be surgically feasible, with acceptable MPR rates and a safety profile aligned with expectations for r
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: No high-priority finds today (best candidate scored 7/10).
Aging, longevity, and population health
Aging, longevity, and population health: No high-priority finds today (best candidate scored 6/10).
Rare diseases with high unmet need
42750094 · Associations Between Short-Term Changes in Disease Activity and Long-Term Clinical Outcomes in Activated Phosphoinositide 3-Kinase Delta Syndrome. · 8/10 · In this clinical trial setting, short-term improvements in immunodeficiency and dysregulation following treatment with leniolisib were associated with longer-term improvements in c 42752907 · Diagnosis Through Whole Genome Sequencing and Care Utilization in Children With Severe Illness. · 8/10 · These findings suggest that while longitudinal health care utilization remains intensive following a genetic diagnosis, identifying these conditions is important for accurately map
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
42753638 · Global incidence of chronic lymphocytic leukemia: A systematic review and meta-analysis. · 7/10 · Treatment Innovation 42754231 · Acute Myeloid Leukemia With KMT2A Amplification: A TP53-Alteration-Enriched Subgroup Associated With Chromoanagenesis and Poor Prognosis. · 7/10 · Treatment Innovation 42751015 · Initial preclinical investigation of aclarubicin treatment in primary cutaneous T-cell lymphoma cells. · 6/10 · Treatment Innovation 42751490 · Interferon-α vs hydroxyurea in patients with myeloproliferative neoplasms (DALIAH): a multicentre, randomised, open-label, phase 3 trial in Denmark. · 6/10 · Treatment Innovation 42750591 · Immune checkpoint knockout screen reveals TIGIT-CD155 interaction as a significant modulator of adapter CAR-T cell function in acute myeloid leukemia. · 5/10 · Treatment Innovation
CBC-based diagnostics and machine learning in hematology
No retained standard-priority articles.
Early cancer detection
42750412 · The next-generation biomarkers in early-stage triple negative breast cancer. · 7/10 · Early Detection 42750947 · CellSearch-based isolation of circulating tumor cells from ascitic fluid enables molecular characterization of ovarian cancer. · 7/10 · Early Detection 42751205 · Optimizing invitation letters for national cancer screening programs: Qualitative usability testing. · 6/10 · Early Detection 42751476 · Circulating immune profiling reveals immune signatures associated with disease stage and outcome in endometrial cancer. · 6/10 · Early Detection 42752241 · Pancreatic Cancer Screening and Early Detection: Where Are We Now? · 6/10 · Early Detection
AI/ML in clinical diagnostics and imaging
42750836 · Interpretable multimodal MRI fusion in Alzheimer's disease classification using extended parallel multilink joint ICA and 3D ResNet. · 5/10 · Diagnostics 42753963 · Toward Precision Photobiomodulation for Radiation-Induced Xerostomia: Clinical Evidence, Salivary Biomarkers, and Artificial Intelligence. · 5/10 · Diagnostics 42754475 · The value of (18)F-fluoride PET in bone metastases: an overview. · 5/10 · Diagnostics
Precision oncology and genomic medicine
42753723 · Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets. · 6/10 · Genomics/Precision Medicine 42750454 · Fertility-Sparing Treatment of Endometrial Cancer: Survey of Australian Practice. · 5/10 · Genomics/Precision Medicine 42751175 · Human cardiovascular organoids: Biomedical applications and ethical challenges. · 5/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42750897 · The role of neurosurgery for brain metastases between 2012 and 2022: Results of the multicenter SUBAROMA study. · 6/10 · Treatment Innovation 42753579 · Agrimol B induces apoptosis and ferroptosis in acute monocytic leukemia by targeting EGFR/ERK1/2 signaling and activating SIRT1. · 5/10 · Treatment Innovation 42753819 · Thymine-functionalized bPEI nanocomplexes for synergistic STING activation and PD-L1 silencing to potentiate cancer immunotherapy. · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42754096 · The Incretin Mirage: Epigenetic Memory as a Potential Driver of Post-Treatment Weight Regain. · 7/10 · Public Health 42754392 · Do Preoperative Glucagon-Like Peptide-1 Receptor Agonists Influence Lumbar Fusion Outcomes? A Systematic Review and Meta-Analysis. · 7/10 · Public Health 42753892 · Neighbourhood Environment and Cardiorespiratory Fitness in Youth: A Cross-Sectional Random Forest Analysis. · 6/10 · Public Health 42753932 · Handgrip strength asymmetry and cardiometabolic multimorbidity in Chinese middle-aged and older adults: a longitudinal cohort study. · 6/10 · Public Health
Aging, longevity, and population health
42752400 · Effects of a Nutritionally Balanced Between-Meal Food Product on Brain Function in Older Adults: Protocol for a Randomized Controlled Trial (the MiniMeal Study). · 6/10 · Public Health 42750461 · Probiotics in Cardiometabolic Diseases: Current Evidence, Postbiotic Perspectives, and Future Directions. · 5/10 · Public Health 42751187 · Platelet factor 4 in cognitive, immune and hematopoietic aging: emerging evidence and translational challenges. · 5/10 · Public Health 42751334 · Bridging the gap in aging systems: health literacy and community health worker workforce innovation to address health-related social needs. · 5/10 · Public Health
Rare diseases with high unmet need
No retained standard-priority articles.
💡 UNSOLICITED FINDS
42751510 · Rewiring redox defense: Nrf2-driven antioxidant signaling as a gateway to programmed cell death activation in colorectal cancer. · 7/10 · Other 42750816 · Prostate and pelvic SABR with or without a focal boost: results from a multicenter phase II prospective clinical trial. · 6/10 · Other 42753227 · OnabotulinumtoxinA for Painful Foot Dystonia in Parkinson Disease: A Randomized, Double-Blind, Placebo-Controlled Trial. · 6/10 · Other 42754409 · Adverse childhood experiences and adverse community environments among maternal mortality cases in Arizona. · 6/10 · Other
📊 TODAY'S BREAKDOWN
- By research category: Genomics/Precision Medicine 5 | Early Detection 8 | Treatment Innovation 10 | Other 4 | Public Health 8 | Diagnostics 3
- By evidence maturity: Validated 6 | Exploratory 32
- By watchlist topic:
- Hematologic malignancies: 15 reviewed / 5 kept / highest 7
- CBC-based diagnostics and machine learning in hematology: 0 reviewed / 0 kept / highest 0
- Early cancer detection: 15 reviewed / 8 kept / highest 8
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 4 kept / highest 6
- Precision oncology and genomic medicine: 15 reviewed / 6 kept / highest 8
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 6 kept / highest 8
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 4 kept / highest 7
- Aging, longevity, and population health: 15 reviewed / 4 kept / highest 6
- Rare diseases with high unmet need: 4 reviewed / 2 kept / highest 8
- SENTINEL: 10 reviewed / 4 kept / highest 7
- By source type: peer_reviewed 38 | preprint 0
- Topics with zero 8+ articles this run: Hematologic malignancies; CBC-based diagnostics and machine learning in hematology; AI/ML in clinical diagnostics and imaging; Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk; Aging, longevity, and population health; SENTINEL
🔧 RUN NOTES
- No 48-hour expansion was needed because the run produced at least five relevant records.
- The CBC/ML hematology primary and required fallback searches both returned zero records.
- Per-topic caps were enforced at 15 reviewed candidates; sentinel was capped at 10.
- All selected PMIDs were verified in ESummary and EFetch; no candidate coverage failures occurred.
- No rolling seven-day zero-signal assessment was available from the stale state checkpoint.