📅 PUBMED DAILY TRIAGE — 2026-09-19 Window: 2026-07-23T00:00:00Z → 2026-09-19T09:00:00Z (CRDT) Topics scanned: 9 | Articles reviewed: 111 | Candidates evaluated: 111 High priority: 6 | Standard: 35 | Low/archive: 0 | Unsolicited finds: 1 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
• PM42758055 · TP53-Altered Aggressive Large B-Cell Lymphoma (LBCL) Outcomes by Treatment Modality: A Mul · 7/10 · Molecular subclassification has identified an LBCL A53 phenotype characterized by TP53 alterations, • PM42760248 · A phase IIa study of the anti-PD-L1 antibody avelumab in relapsed/refractory PTCL: The AVA · 6/10 · Intention-to-treat analysis showed an overall response rate of 14.3%, median progression-free surviv
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate scored 0/10)
Early cancer detection
• PM42760086 · PETER: protocol for a randomised controlled trial of the effects of postal and digital inv · 6/10 · s will be disseminated through peer-reviewed publications. • PM42759923 · CRISPR-based diagnostics as a specificity layer for the early detection of pancreatic canc · 5/10 · In complex biofluids, these approaches may be confounded by background signal and amplification arti • PM42759922 · Plasma cfDNA fragmentomics enables non-invasive detection and preoperative risk stratifica · 5/10 · For cancer detection, the model achieved AUCs of 0.9484 (training), 0.9446 (internal validation), an
AI/ML in clinical diagnostics and imaging
No high-priority finds today (best candidate scored 6/10)
Precision oncology and genomic medicine
No high-priority finds today (best candidate scored 7/10)
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
• PM42759981 · CD28-ICOS costimulation enhances the therapeutic efficacy of L1CAM-targeted CAR-T cells ag · 6/10 · S: High L1CAM expression correlated with aggressive clinicopathological features and adverse prognos
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
No high-priority finds today (best candidate scored 5/10)
Aging, longevity, and population health
No high-priority finds today (best candidate scored 6/10)
Rare diseases with high unmet need
No high-priority finds today (best candidate scored 6/10)
🟢⚪ STANDARD (4-7) — Top by Topic
Hematologic malignancies
• PM42760033 · Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients-A Post Hoc B · 7/10 · Other • PM42759157 · Optimizing perioperative intravenous corticosteroid dosing for postoperative out · 7/10 · Other • PM42758401 · Molecular Response, Event-Free Survival, and Treatment-Free Remission in Myelopr · 7/10 · Genomics/Precision Medicine
Early cancer detection
• PM42760089 · AI-based applications supporting informal caregivers in childhood caries prevent · 6/10 · Early Detection • PM42759972 · Leveraging time-series electronic health records with large language models for · 6/10 · Early Detection
AI/ML in clinical diagnostics and imaging
• PM42759972 · Leveraging time-series electronic health records with large language models for · 6/10 · Early Detection • PM42760213 · Artificial Intelligence in Respiratory Medicine: Applications, Methodological Ch · 6/10 · Diagnostics • PM42759982 · CT-based deep foundation model for predicting immune checkpoint inhibitor-induce · 6/10 · Treatment Innovation • PM42759832 · Comprehensive Artificial Intelligence Based Analysis of Pre- and Post-operative · 6/10 · Diagnostics • PM42759726 · Endoscopic Artificial Intelligence for Invasion-Depth Prediction in Superficial · 6/10 · Diagnostics
Precision oncology and genomic medicine
• PM42758401 · Molecular Response, Event-Free Survival, and Treatment-Free Remission in Myelopr · 7/10 · Genomics/Precision Medicine • PM42759265 · Standard targeted therapy implementation for driver alterations newly identified · 7/10 · Treatment Innovation • PM42759041 · Biomarkers for successful allergen immunotherapy: are we there yet? · 6/10 · Treatment Innovation • PM42760190 · Advances in the role of house dust mite allergen components in the pathogenesis · 6/10 · Treatment Innovation • PM42760194 · Molecular targeted therapy for thyroid cancer in Japan: Current status and futur · 5/10 · Treatment Innovation
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
• PM42759583 · Impact of intensity, duration and type of acute and chronic exercise on the immu · 7/10 · Treatment Innovation • PM42759982 · CT-based deep foundation model for predicting immune checkpoint inhibitor-induce · 6/10 · Treatment Innovation • PM42760194 · Molecular targeted therapy for thyroid cancer in Japan: Current status and futur · 5/10 · Treatment Innovation • PM42760160 · Non-canonical Wnt11/PCP/YAP signaling mediates epithelial-mesenchymal transition · 5/10 · Treatment Innovation • PM42760117 · Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 block · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
• PM42758865 · The global burden of metabolic and alcohol-associated liver disease (MetALD). · 5/10 · Prevention • PM42760157 · Epigenetic determinants of GLP-1 responsiveness: Integrating dietary modulation · 5/10 · Genomics/Precision Medicine • PM42759692 · Perioperative management of SGLT2 inhibitors: balancing euglycaemic ketoacidosis · 5/10 · Prevention • PM42759644 · Immunometabolic Regulation of Macrophage Function in Cardio-Hepatic-Renal Comorb · 5/10 · Genomics/Precision Medicine • PM42758714 · Divergent effects of semaglutide and CRV431 Co-therapy on liver fibrosis and HCC · 5/10 · Prevention
Aging, longevity, and population health
• PM42759983 · Frailty of older patients is not reflected in the melanoma tumor microenvironmen · 6/10 · Public Health • PM42758105 · Telomeres in mitosis: organization and dynamics. · 4/10 · Genomics/Precision Medicine • PM42760016 · Growing old before growing up. · 4/10 · Public Health • PM42760139 · The GenV Biobank: Enabling Biological Research in a Large Longitudinal Populatio · 4/10 · Other • PM42759945 · Somatic Mosaicism of the Brain: The Functional Implications of Post-Zygotic Muta · 4/10 · Genomics/Precision Medicine
Rare diseases with high unmet need
• PM42758006 · Skin biopsy in adult-onset Still's disease: A specific, rapid, and widely availa · 6/10 · Diagnostics • PM42759888 · Patient-Derived 3D Cell Models as New Approach Methodologies: Applications, Adva · 6/10 · Drug Development • PM42759810 · Bridging the translational gap in drug repurposing for rare diseases: clinical s · 6/10 · Drug Development • PM42759654 · Exploratory assessment of catestatin and thrombospondin-1 as potential biomarker · 6/10 · Drug Development • PM42758787 · Living with a rare disease: Why lived experience must shape research. · 6/10 · Drug Development
📊 TODAY'S BREAKDOWN
- By research category: Treatment Innovation: 11, Genomics/Precision Medicine: 6, Early Detection: 6, Diagnostics: 5, Other: 4, Drug Development: 4, Prevention: 3, Public Health: 2
- By evidence maturity: Exploratory: 41
- By source type: peer_reviewed 41 | preprint 0
- Topics with zero 8+ articles: CBC-based diagnostics and machine learning in hematology, AI/ML in clinical diagnostics and imaging, Precision oncology and genomic medicine, Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk, Aging, longevity, and population health
📊 By Watchlist Topic (reviewed / kept / highest score)
• Hematologic malignancies: 15 reviewed / 13 kept / best 7/10 • CBC-based diagnostics and machine learning in hematology: 0 reviewed / 0 kept / best 0/10 • Early cancer detection: 15 reviewed / 15 kept / best 6/10 • AI/ML in clinical diagnostics and imaging: 15 reviewed / 15 kept / best 6/10 • Precision oncology and genomic medicine: 14 reviewed / 13 kept / best 7/10 • Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 14 kept / best 7/10 • Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 14 kept / best 5/10 • Aging, longevity, and population health: 5 reviewed / 5 kept / best 6/10 • Rare diseases with high unmet need: 7 reviewed / 6 kept / best 6/10 • Sentinel Scan (unsolicited finds): 10 reviewed / 8 kept / best 7/10
🔧 RUN NOTES
- Window: CRDT 2026-07-23 → 2026-09-19, no expansion triggered (all topics returned ≥1 result)
- CBC/ML hematology: primary and required fallback queries both returned zero records; both searches are logged
- Rare diseases: 7 results in window, below the 15-candidate cap; all 7 were reviewed
- Sentinel scan: capped at 10; unsolicited finds flagged
- Scoring: rule-based heuristic v1.3 (conservative); abstract-level classification
- Run status: SUCCESS