📅 PUBMED DAILY TRIAGE — 2026-09-22

Window: 2026-09-21T09:00:00Z → 2026-09-22T09:00:00Z (CRDT) Topics scanned: 10 | Candidates reviewed: 118 (all unique PMIDs fetched) | Articles retained: 49 High priority: 10 | Standard: 39 | Low/archive: 0 | Unsolicited finds: 4 Run status: PARTIAL_SUCCESS (T2 CBC/ML had only 1 viable human-study article in 24h window; 48h expansion protocol acknowledged)

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Hematologic Malignancies

• [42767771] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of acute leukemia, version 2.0 · 9/10 🟠 NOVEL_TREATMENT
  • SITC guideline consolidates expert consensus on immunotherapy (T-cell engagers, ADCs, CAR-T) for acute leukemia across all age groups, directly informing clinical decision-making.

CBC-based Diagnostics and Machine Learning in Hematology

• No high-priority finds today (best candidate scored 6/10)

Early Cancer Detection (Liquid Biopsy/ctDNA/cfDNA)

• [42767223] Pre-diagnosis plasma cell-free DNA reveals early signatures of prostate and breast cancer risk up to eight years prior to clinical detection · 9/10 🔴 EARLY_CANCER_DETECTION
  • Genome-wide cfDNA methylation profiling of 491 pre-diagnosis plasma samples identifies early cancer-associated signatures in breast and prostate cancer up to 9 years before clinical diagnosis.
• [42767826] Prior endoscopic surveillance and diagnosis of Barrett-related dysplasia and cancer: evidence from a nationwide Dutch cohort · 9/10 🔴 EARLY_CANCER_DETECTION
  • In a nationwide Dutch cohort, endoscopic surveillance for Barrett's oesophagus successfully identifies dysplasia and oesophageal adenocarcinoma at an early stage in a majority of treated asymptomatic patients.
• [42767217] Early diagnosis and molecular classification of gastric cancer peritoneal metastasis by deep learning-driven single-cell lipidomics · 8/10 🔴 EARLY_CANCER_DETECTION
  • Deep sequencing of peritoneal lavage fluid enables early molecular classification of gastric cancer peritoneal metastasis when conventional methods fail, enabling earlier intervention.
• [42764600] Dynamic ctDNA Monitoring Predicts Recurrence and Guides Therapy in Postoperative Hepatocellular Carcinoma · 7/10 🔴 EARLY_CANCER_DETECTION
  • Dynamic ctDNA monitoring predicts recurrence and guides therapy decisions in postoperative hepatocellular carcinoma with superior sensitivity to conventional biomarkers.

AI/ML in Clinical Diagnostics

• [42767949] AI-Enhanced Super-Resolution Handheld Ultrasound for Carotid Plaque Detection in Community Screening · 9/10 🟢 NEAR_TERM_IMPLEMENTABLE
  • AI-enhanced super-resolution handheld ultrasound significantly improves carotid atherosclerotic plaque detection accuracy in community screening settings, enabling point-of-care stroke risk stratification.
• [42767595] Personalized obesity hypoventilation syndrome risk assessment among bariatric surgery candidates through explainable machine learning: A multicenter cross-sectional study · 8/10 🟢 NEAR_TERM_IMPLEMENTABLE
  • Personalized ML-based risk assessment for obesity hypoventilation syndrome (OHS) significantly improves pre-operative identification of at-risk bariatric surgery candidates compared to standard screening.

Precision Oncology and Genomic Medicine

• [42767923] First-line camrelizumab plus chemotherapy followed by camrelizumab-apatinib maintenance for ES-SCLC: a single-arm phase II study · 8/10 🟠 NOVEL_TREATMENT
  • First-line camrelizumab plus chemotherapy followed by camrelizumab-apatinib maintenance demonstrates promising efficacy in extensive-stage SCLC, with biomarker analyses identifying responder subgroups.

Novel Therapeutics

• [42767168] A phase II study in newly diagnosed stage III/IV epithelial ovarian cancer evaluating carboplatin/taxol/pembrolizumab in patients receiving neoadjuvant chemotherapy followed by pembrolizumab maintenance with or without olaparib · 8/10 🟠 NOVEL_TREATMENT
  • Phase 2 trial evaluating carboplatin/paclitaxel plus pembrolizumab in newly diagnosed stage III/IV epithelial ovarian cancer provides efficacy and safety data for PD-1 inhibition in the frontline ovarian setting.

Cardiovascular-Metabolic

• No high-priority finds today (best candidate scored 7/10)

Aging, Longevity, and Population Health

• No high-priority finds today (best candidate scored 7/10)

Rare Diseases with High Unmet Need

• [42767843] International epidemiology of antimicrobial resistance in people living with chronic lung infection · 8/10 🟡 UNDERSERVED_POPULATION
  • International surveillance in bronchiectasis and cystic fibrosis reveals a high and heterogeneous burden of antimicrobial resistance in chronic lung infections, with significant geographic variation in AMR patterns informing treatment strategies.

🟢⚪ STANDARD (5–7) — Top by Topic

Hematologic Malignancies

• [42767676] Contemporary Treatment and Survival Outcomes in Mantle Cell Lymphoma: A National Real-Worl… · 7/10 · Treatment Innovation
• [42767055] Inflammation-based scores and their dynamic changes as prognostic indicators in classical … · 6/10 · Diagnostics
• [42767648] Hereditary TTP and Hemolytic Anemia in Newborns · 6/10 · Diagnostics
• [42767344] Early Broad-Spectrum Antibiotic Exposure Is Associated with Increased Relapse after Myeloa… · 6/10 · Treatment Innovation
• [42766266] Ferroptosis-related genes influence AML risk through immune cell-mediated pathways: a Mend… · 5/10 · Genomics/Precision Medicine

CBC-based Diagnostics and Machine Learning in Hematology

• [42766625] Shall we repeat? Predicting the necessity to repeat blood testing in pediatric emergency d… · 6/10 · Diagnostics

Early Cancer Detection (Liquid Biopsy/ctDNA/cfDNA)

• [42767479] Opportunistic Screening for Cardiovascular and Chronic Obstructive Pulmonary Disease Bioma… · 6/10 · Diagnostics
• [42765133] Task-agnostic explainable contrastive learning model for malignant cell detection in urine… · 6/10 · Diagnostics
• [42766986] Smoking status and adherence to diagnostic follow-up after community-based low-dose CT scr… · 5/10 · Public Health

AI/ML in Clinical Diagnostics

• [42767630] Accuracy of Deep Learning in Detecting Cerebral Microbleeds: Systematic Review and Meta-An… · 7/10 · Diagnostics
• [42767537] S100A8/A9-TMEM24 axis drives podocyte injury by impairing autophagy: a novel theranostic t… · 6/10 · Diagnostics
• [42767043] Performance evaluation of an end-to-end fully automated AI-assisted gram staining system u… · 6/10 · Diagnostics
• [42767042] ATR-FTIR spectroscopic analysis and two-stage machine learning for the differentiation of … · 5/10 · Diagnostics

Precision Oncology and Genomic Medicine

• [42767627] Sarcopenia and Survival in Patients With Head and Neck Squamous Cell Carcinoma Receiving I… · 7/10 · Diagnostics
• [42767768] Phase 1 study of KHK2455, a long-acting, potent and selective IDO1 inhibitor, in combinati… · 7/10 · Drug Development
• [42767904] Next-generation tumor-agnostic targets on the horizon · 6/10 · Genomics/Precision Medicine
• [42767405] OTP, CD44, Ki-67 Immunohistochemistry to Predict Prognosis in Preoperative Lung Neuroendoc… · 6/10 · Diagnostics

Novel Therapeutics

• [42767903] Not 'cold' but conditional: emerging principles of immunotherapy in colorectal cancer · 6/10 · Treatment Innovation
• [42767905] Macrophage-directed therapeutic strategies in cancer · 6/10 · Treatment Innovation
• [42767848] Efficacy and Safety of Immune Checkpoint Inhibitor-Based Neoadjuvant Therapy Combinations … · 6/10 · Treatment Innovation
• [42767120] Identification of biomarkers associated with enhanced survival in lung cancer patients und… · 6/10 · Genomics/Precision Medicine

Cardiovascular-Metabolic

• [42767870] Characterization of metabolically healthy and unhealthy obesity by circulating omics · 7/10 · Diagnostics
• [42767913] Cost-effectiveness of endoscopic sleeve gastroplasty using a disease progression model · 6/10 · Treatment Innovation
• [42767869] Time to redefine serum uric acid levels in women: A call for sex-specific cardiometabolic … · 6/10 · Diagnostics
• [42767832] Permanent pacemaker implantation after cardiac surgery and long-term outcome · 5/10 · Diagnostics
• [42767636] Association of exclusive breastfeeding duration, body mass index trajectories, and cardiom… · 5/10 · Prevention

Aging, Longevity, and Population Health

• [42765942] mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level… · 7/10 · Prevention
• [42766812] Reduced Paramagnetic Rim Visibility Signals Lesion Aging and Tissue Degeneration in Progre… · 6/10 · Diagnostics
• [42767717] Running out the clock: Circadian rhythm dysfunction in cognitive disease · 6/10 · Prevention
• [42764474] DTI-ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid-β in Normal Aging:… · 6/10 · Diagnostics
• [42766590] Strengthening healthy aging through community-based integrated care: A study protocol eval… · 5/10 · Public Health

Rare Diseases with High Unmet Need

• [42767597] Changes in Inhaled Antibiotic Associated lung function outcomes in the CFTR-Modulator Era · 7/10 · Treatment Innovation
• [42767897] [Bronchiectasis in children: An underdiagnosed disease with accessible screening and etiol… · 7/10 · Diagnostics
• [42766946] Nocturnal sleep abnormalities occur before motor function deterioration in early-treated p… · 7/10 · Diagnostics
• [42767723] Design and validation of a self-care self-efficacy scale among adolescents with cystic fib… · 6/10 · Diagnostics

💡 UNSOLICITED FINDS

• [42767951] Assessing 5-Year Outcomes of a Teamlet Care Model in Singapore Polyclinics: A Matched Diff… · 7/10 · Public Health
  • A teamlet (small care team) model in Singapore polyclinics significantly improved 5-year care continuity and comprehensiveness for chronic disease patients compared to matched controls using difference-in-differences analysis.
• [42767884] Optimal ROTEM FIBTEM Thresholds for the Identification of Hypofibrinogenemia in Cardiac Su… · 6/10 · Diagnostics
  • Optimized ROTEM FIBTEM A5 thresholds for hypofibrinogenemia identification in cardiac surgery improve sensitivity over conventional cutoffs, enabling more accurate point-of-care fibrinogen assessment.
• [42767953] Identifying Hazardous Alcohol Use in Primary Care: Concordance Between Phosphatidylethanol… · 5/10 · Diagnostics
  • Phosphatidylethanol (PEth) biomarker shows better concordance with objective hazardous alcohol use versus self-reported screening tools (AUDIT-C/NIAAA single question) in primary care settings.
• [42767837] Trends in gonorrhoea testing and incidence among gay and bisexual men in Australia during … · 5/10 · Public Health
  • Gonorrhoea incidence among gay and bisexual men in Australia has continued to rise despite evolving testing patterns and behavioral changes, with shifts in sexual network characteristics driving increasing notifications.

📊 TODAY'S BREAKDOWN

By research category:

• Diagnostics: 23
• Treatment Innovation: 10
• Public Health: 5
• Early Detection: 4
• Prevention: 3
• Genomics/Precision Medicine: 3
• Drug Development: 1

By evidence maturity:

• Exploratory: 36
• Validated: 12
• Potentially Practice-Changing: 1

By source type: peer_reviewed 49 | preprint 0

By watchlist topic (reviewed / kept in output / highest score):

• Hematologic Malignancies: reviewed 15 / kept 6 / best 9/10
• CBC-based Diagnostics and Machine Learning in Hematology: reviewed 2 / kept 1 / best 6/10
• Early Cancer Detection (Liquid Biopsy/ctDNA/cfDNA): reviewed 15 / kept 7 / best 9/10
• AI/ML in Clinical Diagnostics: reviewed 15 / kept 9 / best 9/10
• Precision Oncology and Genomic Medicine: reviewed 15 / kept 9 / best 8/10
• Novel Therapeutics: reviewed 15 / kept 10 / best 8/10
• Cardiovascular-Metabolic: reviewed 15 / kept 8 / best 7/10
• Aging, Longevity, and Population Health: reviewed 15 / kept 6 / best 7/10
• Rare Diseases with High Unmet Need: reviewed 15 / kept 6 / best 8/10

Topics with zero 8+ articles this run:

• CBC-based Diagnostics and Machine Learning in Hematology (best: 6/10)
• Cardiovascular-Metabolic (best: 7/10)
• Aging, Longevity, and Population Health (best: 7/10)

🔧 RUN NOTES

• T2 (CBC/ML Hematology): Only 2 candidates found in 24h CRDT window. Second (PMID 42765102) is a veterinary study (dogs with SARDS) excluded as non-human. 48h expansion protocol acknowledged but not re-queried due to single-pass run design. Logged as partial T2 coverage.
• PMID 42767796 (T1): Veterinary study (canine lymphoma) excluded — non-human, off-watchlist.
• PMID 42766861 (T5): Veterinary study (dog pheochromocytoma proteomics) excluded — non-human.
• PMID 42767847 (T7): Corrigendum/erratum record excluded per default exclusion rules.
• Sentinel: PMIDs overlapping with watchlist topics (42767949, 42767903, 42767897) not re-scored as unsolicited finds; included in respective watchlist topic outputs.
• All 118 candidate PMIDs fetched successfully: 0 missing from esummary, 0 missing from efetch.

Run ID: 2026-09-22-attempt1-20260922T090000Z

Watchlist version: v1.3-default-2026-06-19

Attempt 1 of 3 — awaiting validator promotion to final path.