Digital PCR for Detecting Loss of BAP1 and MTAP in Pleural Fluids of Mesothelioma Patients: Perspectives in the Diagnosis.
Digital PCR detecting lost genes in fluid samples shows promise for confirming mesothelioma diagnoses in patients with unclear presentations.
Pleural mesothelioma (PM) often presents loss of BAP1 and MTAP genes. Finally, this two-gene signature was applied on SPFs in a prospective series of six consecutive patients presenting an undefined diagnosis (negative for PM) and two showed reduced CN.
What the study was
- Study design
- Retrospective diagnostic validation study
- Population
- Pleural mesothelioma patients (n=37)
- Sample size
- 37
- Category
- Early Detection
- Maturity
- Exploratory
- Journal
- Pathology international
Why it surfaced
Digital PCR liquid biopsy from pleural fluid supernatant improves mesothelioma diagnosis; directly EARLY_CANCER_DETECTION; rare cancer with high unmet need; PMID fully reviewed.
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