📅 PUBMED DAILY TRIAGE — 2026-09-29 Window: 2026-09-28T09:00:00Z → 2026-09-29T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: 114 unique PMIDs | Candidates evaluated: 61 High priority: 8 | Standard: 45 | Low/archive: 8 | Unsolicited finds: 6 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
No high-priority finds today (best candidate scored 6/10; PMID 42805761)
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate scored 6/10; PMID 42802638)
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
• PMID 42805147 · Cardio-Oncological Sequelae of Autologous Stem Cell Transplantation: Role of Clonal H · 8/10 → Autologous hematopoietic stem cell transplantation is a major milestone in modern oncohematological therapies; however, both in th. • PMID 42804195 · Diagnostic Delays Associated With a Screening Trial of a Multicancer Early Detection · 3/10 → Study titled: Diagnostic Delays Associated With a Screening Trial of a Multicancer Early Detection Test.. • PMID 42804225 · Diagnostic Delays Associated With a Screening Trial of a Multicancer Early Detection · 3/10 → Study titled: Diagnostic Delays Associated With a Screening Trial of a Multicancer Early Detection Test-Reply..
AI/ML in clinical diagnostics and imaging
• PMID 42805322 · Predicting Arterial Stiffness from Retinal Microvasculature: A Machine Learning Appro · 8/10 → Participants were excluded if OCTA signal strength was below 7 or if PWV recordings showed excessive variability (standard deviati. • PMID 42805462 · Brief Report: Validation of the Sybil Lung Cancer Risk Prediction Model in a Predomin · 8/10 → CONCLUSIONS: Sybil demonstrated robust lung cancer risk prediction in this screening cohort, supporting its generalizability and h.
Precision oncology and genomic medicine
No high-priority finds today (best candidate scored 7/10; PMID 42805853)
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
• PMID 42805763 · Prolonged survival after systemic immune reactivation by aglatimagene besadenovec plu · 9/10 → CONCLUSIONS: In this single-arm phase 2a study, aglatimagene besadenovec plus valacyclovir with ongoing ICI was associated with sy.
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
• PMID 42805885 · Duodeno-ileal magnetic compression anastomoses in metabolic surgery: a systematic rev · 9/10 → Larger comparative studies with longer follow-up are needed; the SNAP malnutrition signal warrants prospective surveillance.
Aging, longevity, and population health
No high-priority finds today (best candidate scored 7/10; PMID 42805656)
Rare diseases with high unmet need
• PMID 42805310 · Autosomal recessive HOXA3 deficiency causes congenital athymia and laryngeal malforma · 8/10 → The loss of the homeodomain causes cytoplasmic retention of the HOXA3 protein, leading to reduced transcriptional activity.
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
• PMID 42805311 · Leniolisib and rapamycin in Activated PI3-Kinase-δ-syndrome: a retrospective ESI · 6/10 · Treatment Innovation • PMID 42805358 · Menin Inhibitors in Acute Myeloid Leukaemia: Mechanisms, Clinical Pharmacology, · 6/10 · Treatment Innovation • PMID 42805761 · Comparative clinical outcomes and single-cell profiling of CD19 CAR-T versus bli · 6/10 · Treatment Innovation • PMID 42805113 · Integrative analysis of m6A-related genetic variants and single-cell RNA sequenc · 5/10 · Treatment Innovation • PMID 42805448 · ZAP-70 as a prognostic laboratory biomarker in chronic lymphocytic leukemia: flo · 5/10 · Treatment Innovation
CBC-based diagnostics and machine learning in hematology
• PMID 42802638 · First-Trimester CBC-Derived Inflammatory Indices for Prediction of Miscarriage: · 6/10 · Diagnostics • PMID 42803118 · Diagnostic value of neutrophil-to-lymphocyte ratio for identifying severe great · 5/10 · Diagnostics
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
• PMID 42804174 · Prostate Cancer Screening and Likelihood of Benefit in Veterans Affairs and Fee- · 6/10 · Early Detection • PMID 42804856 · Patient willingness to de-escalate adjuvant therapy based on predictive biomarke · 6/10 · Early Detection • PMID 42805460 · Gene-Specific Analysis of Clonal Hematopoiesis Identifies the Association betwee · 6/10 · Early Detection • PMID 42805646 · Women in their 40s responding to the 2024 United States Preventive Services Task · 6/10 · Early Detection • PMID 42805923 · Healthcare Providers' Strategies to Improve Breast Cancer Screening Among South · 6/10 · Early Detection
AI/ML in clinical diagnostics and imaging
• PMID 42805547 · Evaluating the Long-Term Malignancy Risk Prediction Accuracy of Major Guidelines · 7/10 · Diagnostics • PMID 42805256 · Machine learning models for suspected pulmonary embolism in emergency department · 6/10 · Diagnostics • PMID 42805808 · Longitudinal body composition changes distinguish pancreatic ductal adenocarcino · 6/10 · Diagnostics • PMID 42805865 · Dual-discriminator Generative Adversarial Network (DD-GAN) for Virtual Elastogra · 6/10 · Diagnostics • PMID 42805915 · Application of synthetic computed tomography based on a deep learning model in p · 6/10 · Diagnostics
Precision oncology and genomic medicine
• PMID 42804994 · A CRISPR/Cas14a-based platform for sensitive and specific single-nucleotide vari · 7/10 · Genomics/Precision Medicine • PMID 42805112 · The inflammatory UPR-IFNG axis reveals LBP as a survival and immunotherapy-respo · 7/10 · Genomics/Precision Medicine • PMID 42805853 · 2025 Taiwan consensus and management guidelines for gastric cancer. · 7/10 · Genomics/Precision Medicine • PMID 42804995 · AI-powered dynamic scattering liquid crystal biosensor for label-free detection · 6/10 · Genomics/Precision Medicine • PMID 42805065 · From orphan receptor to versatile regulator: Redefining LILRB3 as a context-depe · 6/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
• PMID 42805461 · Efficacy and safety of HER2 directed therapies for advanced HER2-mutant non-smal · 7/10 · Treatment Innovation • PMID 42805311 · Leniolisib and rapamycin in Activated PI3-Kinase-δ-syndrome: a retrospective ESI · 6/10 · Treatment Innovation • PMID 42805356 · Tumor-infiltrating B cells in cancer immunity: heterogeneity, spatial organizati · 6/10 · Treatment Innovation • PMID 42805358 · Menin Inhibitors in Acute Myeloid Leukaemia: Mechanisms, Clinical Pharmacology, · 6/10 · Treatment Innovation • PMID 42805360 · Targeting the Untargeted: Emerging Targeted Therapies in Metastatic Melanoma Bey · 6/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
• PMID 42805663 · Adherence and weight loss with a total diet replacement programme for increased · 7/10 · Prevention • PMID 42805765 · Economic evaluation of NT-proBNP testing plus standard clinical assessment versu · 7/10 · Prevention • PMID 42805766 · Mortality and risk factors associated with death in patients with obesity hypove · 7/10 · Prevention • PMID 42805916 · Drug-induced sleep endoscopy-defined upper-airway collapse phenotypes and the pr · 7/10 · Prevention • PMID 42805627 · Cost-effectiveness of implementing the National Health Service England Diabetes · 6/10 · Prevention
Aging, longevity, and population health
• PMID 42805656 · Sarcopenia among chronic kidney disease patients attending a renal clinic in Nor · 7/10 · Public Health • PMID 42803832 · CRP-albumin-lymphocyte index and multisystem diseases: a phenome-wide Mendelian · 6/10 · Public Health • PMID 42805168 · [Periprosthetic Fractures - A Growing Challenge in Orthopedics and Trauma Surger · 5/10 · Public Health • PMID 42805649 · Regional citrate anticoagulation combined with nafamostat mesylate for continuou · 5/10 · Public Health • PMID 42802483 · Autophagy Flux Is Remodeled Sex- and Cell Type-Specifically During Human Aging, · 4/10 · Public Health
Rare diseases with high unmet need
• PMID 42804984 · Depression, pain, and catastrophizing in adults with sickle cell disease and chr · 7/10 · Treatment Innovation • PMID 42804597 · Aggressive Retinal vasculitis and Progressive Outer Retinal Atrophy Associated w · 6/10 · Treatment Innovation • PMID 42804727 · Cranial Neuropathies-Easy to See, Hard to Diagnose: Toward an Integrated Diagnos · 6/10 · Treatment Innovation • PMID 42805187 · Monoallelic variants in BRSK1 are associated with a neurodevelopmental disorder · 6/10 · Treatment Innovation • PMID 42805311 · Leniolisib and rapamycin in Activated PI3-Kinase-δ-syndrome: a retrospective ESI · 6/10 · Treatment Innovation
💡 UNSOLICITED FINDS
• PMID 42805893 · Preoperative anaemia and iron deficiency in Wales: a national retrospective cohort st · 7/10 · Other • PMID 42805858 · Management and oncologic outcomes of rectal cancer patients with downstaged lateral p · 6/10 · Treatment Innovation • PMID 42805898 · Bamboo nodes: Retrospective study of 44 patients. · 6/10 · Treatment Innovation • PMID 42805899 · Risk assessment of uterine masses: a pre-operative biochemical algorithm for risk str · 6/10 · Other • PMID 42805906 · Automated quality assurance of rigid brain CT/MR image registration using a 3D convol · 6/10 · Treatment Innovation • PMID 42805913 · PARP3 Promotes SARS-CoV-2 Replication via Interaction with the Viral Nucleocapsid Pro · 5/10 · Other
📊 TODAY'S BREAKDOWN
By research category:
- Treatment Innovation: 17
- Diagnostics: 9
- Early Detection: 8
- Prevention: 6
- Genomics/Precision Medicine: 5
- Public Health: 5
- Other: 3 By evidence maturity:
- Validated: 44
- Exploratory: 9 By watchlist topic (reviewed / retained / highest score):
- Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 15 reviewed / 5 retained / best 6/10
- CBC-based diagnostics and machine learning in hematolog: 2 reviewed / 2 retained / best 6/10
- Early cancer detection (liquid biopsy, ctDNA, cfDNA): 15 reviewed / 8 retained / best 8/10
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 7 retained / best 8/10
- Precision oncology and genomic medicine: 15 reviewed / 6 retained / best 7/10
- Novel therapeutics: immunotherapy, CAR-T, targeted ther: 15 reviewed / 8 retained / best 9/10
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic: 15 reviewed / 6 retained / best 9/10
- Aging, longevity, and population health: 9 reviewed / 5 retained / best 7/10
- Rare diseases with high unmet need: 15 reviewed / 6 retained / best 8/10
- Sentinel scan: 10 reviewed / 6 retained / best 7/10
By source type: peer_reviewed 53 | preprint 0 Topics with zero 8+ articles this run: Hematologic malignancies (AML, MDS,; CBC-based diagnostics and machine l; Precision oncology and genomic medi; Aging, longevity, and population he
🔧 RUN NOTES
- Window: CRDT 2026-09-28T09:00Z → 2026-09-29T09:00Z (24h incremental).
- 114 unique PMIDs fetched via ESummary + EFetch (all returned; 0 missing).
- Per-topic cap: 15 candidates reviewed per watchlist topic; 10 for sentinel.
- Per-topic STANDARD retention cap: top 5 per topic (score 4-7).
- LOW articles (<4): counted only, not included in articles array.
- Off-domain reclassifications applied to 14 candidates across 6 topics: T1 (Hematologic): 42805799 (colorectal surgery), 42805480 (chemistry), 42805487 (letter). T3 (Early detection): 42805661 (bile leak), 42805485 (metabolic), 42805482 (sepsis), 42804882 (psoriasis), 42804722 (bioinformatics). T4 (AI/ML): 42805277 (colitis biomarkers), 42805314 (miRNA). T5 (Precision oncology): 42805919 (SGLT2 preclinical). T7 (Cardiometabolic): 42805854 (renal cell carcinoma). T9 (Rare diseases): 42804731 (ferret airway), 42804623 (Drosophila), 42804937 (→ AI/ML reclassified).
- Default exclusions: 42805226, 42805487, 42805491, 42805887, 42805889, 42805890 (letters/editorials).
- 42805817 and 42805891 force-excluded (letter and editorial retained in error by abstract-length filter).
- No window expansion needed; all topics returned ≥ 2 candidates.
- T2 (CBC/ML hematology): primary query returned 2 results; cap not hit; no fallback needed.
- T8 (Aging/longevity): AND humans[MeSH] filter applied as per standing instruction.