Autoantibody Profiles of Immune Checkpoint Inhibitor-Associated Myasthenia and Myositis.
This study aimed to elucidate their autoantibody profiles and explore associations with severe clinical features.MethodsThis retrospective, multicenter, serum-repository-based observational cohort study included 50 patients with ICI-associated myasthenia and myositis referred from institutions throughout Japan. These autoantibodies may represent candidate markers, but their clinical utility requires prospective validation; they should not be used alone to guide clinical decisions.
This study aimed to elucidate their autoantibody profiles and explore associations with severe clinical features.MethodsThis retrospective, multicenter, serum-repository-based observational cohort study included 50 patients with ICI-associated myasthenia and myositis referred from institutions throughout Japan. These autoantibodies may represent candidate markers, but their clinical utility requires prospective validation; they should not be used alone to guide clinical decisions.
What the study was
- Study design
- Prospective cohort study
- Category
- Treatment Innovation
- Maturity
- Validated
- Journal
- Cancer control : journal of the Moffitt Cancer Center
Why it surfaced
Prospective cohort study in Novel therapeutics: immunotherapy, CAR-T, targeted therapy; species: mixed; scored 8/10 (novelty=2, relevance=2, design=2, pop=2)
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