📅 PUBMED DAILY TRIAGE — 2026-09-30 Window: 2026-09-29T00:00:00Z → 2026-09-30T09:00:00Z (CRDT) Topics scanned: 9 watchlist + sentinel | Articles reviewed: 119 unique PMIDs | Candidates evaluated: 106 High priority: 16 | Standard: 80 | Low/archive: 10 | Unsolicited finds: 4 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
- PMID:42810712 · Lineage Plasticity-Mediated Resistance to CD7-Directed CAR-T Therapy in Relapsed · 7/10 · 🟠 Novel or significantly improved treatment · With a median follow-up of 8.5 months, the estimated 6-month overall survival (OS) and progression-f
Early cancer detection
- PMID:42810021 · Prognostic value of circulating tumor DNA in treated gastric cancer patients: A · 10/10 · ⬜ Standard addition · ctDNA can serve as an effective prognostic biomarker for gastric cancer patients undergoing treatmen
- PMID:42810958 · Diagnostic and Treatment Intervals for Colorectal Cancer and Associations With O · 9/10 · ⬜ Standard addition · Three models, assessing the diagnostic and the treatment intervals showed a nonlinear association wi
- PMID:42810641 · Artificial Intelligence for early detection of Oral Squamous Cell Carcinoma: A S · 8/10 · 🔴 Early cancer detection or prevention · A consistent reporting framework and greater methodological rigour are needed to support clinical tr
- PMID:42810586 · Final results and predictive biomarkers of response and long-term outcomes with · 8/10 · ⬜ Standard addition · Insights from the comprehensive analysis of RCC tumor molecular components and ctDNA may facilitate
- PMID:42810389 · Immunotherapy for Pleural Mesothelioma. · 8/10 · ⬜ Standard addition · Although robust data support the use of second-line immunotherapy after first-line chemotherapy, the
- PMID:42810034 · Development of a europium-thiosemicarbazide-based nano-optical biosensor for ear · 5/10 · 🔴 Early cancer detection or prevention · ROC analysis yielded an AUC of 1.000, with 90.9% sensitivity and 100% specificity.
AI/ML in clinical diagnostics and imaging
- PMID:42810146 · Prospective multicentre expert evaluation of an artificial intelligence-based on · 8/10 · ⬜ Standard addition · OneRx.AI demonstrated high expert-rated clinical performance in this exploratory, ceiling-affected e
- PMID:42809903 · Gallbladder involvement in metachromatic leukodystrophy: a systematic review and · 8/10 · ⬜ Standard addition · Fifty-one PubMed/MEDLINE records and three additional reports were identified; 37 reports were inclu
- PMID:42810820 · Bacterial detection in paediatric cancer patients with febrile neutropenia, from · 8/10 · 🟢 Near-term implementable finding · No biomarker demonstrated sufficient accuracy for standalone use.
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- PMID:42810412 · Tocilizumab, atezolizumab, and stereotactic radiotherapy in recurrent glioblasto · 9/10 · ⬜ Standard addition · These findings suggest that the combination of tocilizumab, atezolizumab, and FSRT was safe and well
- PMID:42810719 · Autoantibody Profiles of Immune Checkpoint Inhibitor-Associated Myasthenia and M · 8/10 · 🟢 Near-term implementable finding · Reactivity on commercial paraneoplastic neurological syndrome (PNS) immunodot assays, accompanied by
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- PMID:42810872 · Association between lipoprotein(a) and structural degeneration of bioprosthetic · 8/10 · ⬜ Standard addition · Lp(a) may represent a useful biomarker for identifying patients at higher risk of valve deterioratio
- PMID:42810703 · Early aortic valve replacement for asymptomatic severe aortic stenosis: an updat · 8/10 · ⬜ Standard addition · Treatment benefits varied according to clinical and hemodynamic profiles: greater baseline valve sev
Aging, longevity, and population health
- PMID:42809602 · Effectiveness of Interventions to Prevent Frailty in Older Adults: A Systematic · 10/10 · ⬜ Standard addition · The effectiveness of exercise interventions to improve physical endurance depends on factors such as
- PMID:42809440 · Inflammatory Aging-Driven Immune Axis Imbalance and the Mechanisms of Chronicity · 8/10 · ⬜ Standard addition · Our findings support a hypothesis-generating conceptual framework in which inflammaging is associate
Topics with no HIGH finds today:
- CBC-based diagnostics and machine learning in hematology: best scored 6/10
- Precision oncology and genomic medicine: best scored 8/10
- Rare diseases with high unmet need: best scored 8/10
🟢⚪ STANDARD (4–7) — Top by Topic
Hematologic malignancies
- PMID:42810732 · BCMA Targeted Therapies and Their Impact on Outcomes in Relapsed or Re · 7/10 · Treatment Innovation
- PMID:42809731 · Racial and Ethnic Disparities in Treatment Cost and Utilization in Ped · 7/10 · Diagnostics
- PMID:42809701 · Toward a Cure in Multiple Myeloma: Redefining Induction Therapy and th · 7/10 · Diagnostics
- PMID:42809147 · A systematic review of the frequency of sleep evaluations, sleep disor · 7/10 · Treatment Innovation
- PMID:42810169 · Childhood serum DDE concentrations and acute lymphoblastic leukemia in · 6/10 · Diagnostics
CBC-based diagnostics and machine learning in hematology
- PMID:42809856 · Population-specific pediatric reference intervals for complete blood c · 6/10 · Diagnostics
Early cancer detection
- PMID:42810150 · Reflections on adjuvant pembrolizumab for triple-negative breast cance · 7/10 · Treatment Innovation
- PMID:42808058 · Sociodemographic profile of individuals eligible for lung cancer scree · 7/10 · Diagnostics
- PMID:42810838 · Clinical performance and practical implications of continuous glucose · 5/10 · Diagnostics
- PMID:42810013 · Birt-Hogg-Dubé syndrome: From molecular mechanisms to emerging systemi · 4/10 · Genomics/Precision Medicine
- PMID:42810594 · CODNet models enable real-time assessment of colorectal cancer organoi · 4/10 · Diagnostics
AI/ML in clinical diagnostics and imaging
- PMID:42810839 · Improving early detection of critical congenital heart disease in a hi · 7/10 · Diagnostics
- PMID:42810378 · Effect of pre-existing dementia on cancer-specific and all-cause morta · 7/10 · Diagnostics
- PMID:42810100 · Distinct EEG functional network alterations in Parkinson's disease and · 7/10 · Diagnostics
- PMID:42809845 · Detecting Misspelled Drug Names Using Transformer-Based Language Model · 7/10 · Diagnostics
- PMID:42810842 · A single-center open-label, randomized, parallel-group controlled clin · 7/10 · Diagnostics
Precision oncology and genomic medicine
- PMID:42810554 · Characterization, pathogenicity and complete genome of Klebsiella aero · 5/10 · Genomics/Precision Medicine
- PMID:42810550 · Measles Whole Genome Sequencing by an Illumina Tiled Amplification Met · 4/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- PMID:42810772 · Interleukin-22 reflects adverse cardiometabolic features in SLE. · 6/10 · Treatment Innovation
- PMID:42809188 · An Update of Oxidative Stress in Atherosclerosis with Emphasis on the · 6/10 · Treatment Innovation
- PMID:42810929 · Immune checkpoint inhibitors versus chemotherapy in COVID-19 among can · 5/10 · Treatment Innovation
- PMID:42810855 · Interleukin-33 alleviates the immunosuppressive tumor microenvironment · 5/10 · Treatment Innovation
- PMID:42810571 · PYGO2 Ablation Promotes Lymphoid Organization and STING-Dependent Anti · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- PMID:42810621 · SGLT2 Inhibitors and Nephrolithiasis Risk in Adults With Type 2 Diabet · 7/10 · Drug Development
- PMID:42810786 · Cohort profile update: the Finnish Genetics of Pre-eclampsia Consortiu · 6/10 · Drug Development
- PMID:42810778 · Finerenone improves vascular function in association with reduced aort · 6/10 · Drug Development
- PMID:42810756 · Difference in the prevalence of metabolic syndrome components between · 6/10 · Drug Development
- PMID:42810614 · Comparative outcomes of GLP-1 receptor agonist and SGLT2 inhibitor use · 5/10 · Drug Development
Aging, longevity, and population health
- PMID:42809545 · Prognostic impact of postoperative complications among elderly patient · 7/10 · Public Health
- PMID:42809105 · Effects of Rhythm Control versus Rate Control on Atrial Fibrillation a · 7/10 · Public Health
- PMID:42809599 · Advance Care Planning in Orthopedics. · 6/10 · Public Health
- PMID:42809783 · Sociodemographic, Mental Health, Loneliness, and Clinical Predictors A · 5/10 · Public Health
- PMID:42809038 · Default mode network functional connectivity is associated with intent · 5/10 · Public Health
Rare diseases with high unmet need
- PMID:42809223 · Expanding the definition of unmet medical need: Findings from a multis · 7/10 · Genomics/Precision Medicine
- PMID:42810926 · Orphan drug regulation: a global comparison of the United States Food · 6/10 · Genomics/Precision Medicine
- PMID:42809677 · Bilateral Vortex Keratopathy in a Patient Receiving Long-Term Ribocicl · 6/10 · Genomics/Precision Medicine
- PMID:42809422 · Ubiquitin-Dependent Protein Quality Control in Polyglutamine Diseases. · 6/10 · Genomics/Precision Medicine
- PMID:42810859 · Diagnostic Yield of Laboratory-Based Screening for Hypophosphatasia Am · 5/10 · Genomics/Precision Medicine
💡 UNSOLICITED FINDS
No high-signal unsolicited finds this run.
📊 TODAY'S BREAKDOWN
By research category:
- Diagnostics: 40
- Treatment Innovation: 23
- Genomics/Precision Medicine: 12
- Drug Development: 10
- Other: 10
- Public Health: 9
- Early Detection: 1
- Prevention: 1
By evidence maturity:
- Exploratory: 84
- Validated: 12
- Potentially Practice-Changing: 10
By watchlist topic (reviewed / retained / highest score):
- Hematologic malignancies: 15 reviewed / 13 retained / best 7/10
- CBC-based diagnostics and machine learning in hematology: 1 reviewed / 1 retained / best 6/10
- Early cancer detection: 15 reviewed / 11 retained / best 10/10
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 35 retained / best 9/10
- Precision oncology and genomic medicine: 15 reviewed / 6 retained / best 8/10
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 20 retained / best 9/10
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 12 retained / best 8/10
- Aging, longevity, and population health: 15 reviewed / 14 retained / best 10/10
- Rare diseases with high unmet need: 15 reviewed / 13 retained / best 8/10
- Sentinel: 10 reviewed / 4 retained / best 5/10
By source type: peer_reviewed 106 | preprint 0
Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology
🔧 RUN NOTES
- CRDT window: 2026-09-29 → 2026-09-30 (24 hours)
- 119 unique PMIDs retrieved; 119/119 ESummary + EFetch fetched
- Off-domain articles excluded (physics/materials/veterinary/agriculture)
- Letters, Editorials, Comments excluded by publication type
- Post-scoring corrections applied to 6 articles: false-positive flags and study-design errors corrected
- Attempt: 1 of 3