Incidental detection of JAK2 V617F mutations in next-generation sequencing analysis of solid tumours: a guide to further workup.
Systematic evaluation of unexpected blood cancer mutations found in tumor tests can detect early hematologic disease.
This clinical observational / translational study examined Incidental detection of JAK2 V617F mutations in next-generation sequencing analysis of solid tumours: a guide to further workup. A work-up for potential haematological disease should be undertaken when an alteration associated with haematological neoplasms is identified in solid tumour NGS panels, particularly when the VAF is different compared to the VAF of other tumour-associated variants.
What the study was
- Study design
- Clinical observational / translational study
- Population
- Human participants or patients described in the PubMed abstract
- Sample size
- 9
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Journal of clinical pathology
Why it surfaced
Clinical observational / translational study; conservative rapid-triage score based on novelty, clinical relevance, design quality, and population or unmet need.
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