📅 PUBMED DAILY TRIAGE — 2026-10-02 Window: 2026-10-01T00:00:00Z → 2026-10-02T09:11:51Z (CRDT) Topics scanned: 10 | Articles reviewed: 124 | Candidates evaluated: 131 High priority: 10 | Standard: 41 | Low/archive: 0 | Unsolicited finds: 4 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
42822478 · Felzartamab plus lenalidomide-dexamethasone versus lenalidomide-dexamethasone for relapsed or refractory multiple myeloma: an open-label, parallel-controlled, randomised, phase 3 trial. · 10/10 · INTERPRETATION: Felzartamab plus lenalidomide-dexamethasone significantly prolonged progression-free survival compared with lenalidomide-dexamethasone alone, supporting felzartamab plus lenalidomide-dexamethasone as a potential new treatment option for Chinese patients with relapsed or refractory multiple myeloma. 42823167 · Favorable Outcome of Intensive Treatment for Relapsed Diffuse Large B Cell Lymphoma With Secondary Central Nervous System Involvement. · 8/10 · Intensive treatment may substantially improve survival in relapsed DLBCL patients with CNS involvement.
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate scored 0/10).
Early cancer detection
42823331 · Clinical impact of prospective circulating tumour DNA testing for minimal residual disease in colorectal cancer: the INTERCEPT programme experience. · 7/10 · Multitimepoint testing improves sensitivity for recurrence (79 point 9% vs 48 point 5%) and may enable earlier, potentially curative interventions.
AI/ML in clinical diagnostics and imaging
42823116 · Diagnostic accuracy of a DenseNet-121 deep learning algorithm for chest radiograph triage in health assessment applicants: a prospective shadow-mode validation study in Nepal. · 9/10 · The DenseNet-121 algorithm demonstrated high point-estimate sensitivity and excellent discrimination for chest radiograph triage in a Nepali health-assessment population, supporting its potential as a radiographic abnormality rule-out triage tool (NPV 99 point 67%); this does not constitute microbiological exclusion of active pulmonary tuberculosis. 42819918 · Artificial intelligence for rapid on-site evaluation of lymph node fine-needle aspiration: improving diagnostic efficiency and accuracy. · 9/10 · In this study, AI-ROSE showed higher sensitivity and diagnostic accuracy than traditional exfoliative cytology for lymph node biopsy. 42821602 · Graph theory-based machine learning for automated fibromyalgia diagnosis using fMRI during an emotional task. · 8/10 · This approach demonstrates promising potential for enhancing diagnostic accuracy and supporting psychological and psychiatric interventions. 42819959 · New Primary and Secondary Prevention Measures for Cutaneous Melanoma: A Systematic Review. · 8/10 · Most studies achieved moderate to high methodological quality, but diagnostic accuracy studies revealed some issues showing that require relevant improvements in diagnostic accuracy and standardization.
Precision oncology and genomic medicine
No high-priority finds today (best candidate scored 7/10).
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42823172 · Complete Response Durability After TAR-200 and Nadofaragene Firadenovec in BCG-unresponsive Bladder CIS. · 9/10 · Restricted mean survival time (RMST) for DoR was estimated at 6, 12, 18, and 24 months. 42823088 · Toripalimab consolidation after chemoradiotherapy in limited-stage small cell lung cancer: a phase II, randomized controlled study (GASTO-1052A). · 9/10 · Consolidative toripalimab showed promising signals of improved PFS and OS with a manageable safety profile in patients with LS-SCLC.
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
No high-priority finds today (best candidate scored 7/10).
Aging, longevity, and population health
No high-priority finds today (best candidate scored 7/10).
Rare diseases with high unmet need
No high-priority finds today (best candidate scored 7/10).
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
42823325 · Beyond Extranodal Site Count: Clinical and Anatomical Characterization of Primary Multifocal Extranodal Diffuse Large B-Cell Lymphoma. · 7/10 · Other 42822732 · Nodal large B-cell lymphoma with intrasinusoidal growth: a clinicopathologic study of a distinctive pattern with diagnostic overlap with intravascular large B-cell lymphoma. · 7/10 · Other 42822838 · Venetoclax consolidation deepens response and enables measurable residual disease-guided finite therapy in BTK inhibitor-treated chronic lymphocytic leukemia. · 6/10 · Other
CBC-based diagnostics and machine learning in hematology
No retained standard-priority find today.
Early cancer detection
42823202 · Gastrointestinal ultrasound in systemic sclerosis: A scoping review of current evidence. · 7/10 · Early Detection 42823168 · Geographic Variations in Demographic, Stage at Diagnosis and Socioeconomic Profiles of Pancreatic Cancer Patients in the United States: A National Cancer Database Analysis (2004-2020). · 7/10 · Early Detection 42822845 · Cell Free DNA Whole Genome in Clinical Practice: A Single Center Seven-Year Experience. · 7/10 · Early Detection 42823093 · Late Exudative Retinal Detachment in Prior Treated Retinoblastoma. · 6/10 · Early Detection 42822647 · Transitioning to HPV-based cervical cancer screening in four low- and middle-income countries: policy and implementation pathways from a scoping review. · 6/10 · Early Detection
AI/ML in clinical diagnostics and imaging
42822184 · Meta-analysis prompt guided multi-task graph transformer for joint analysis of cognitive deficits and psychiatric disorders. · 7/10 · Diagnostics 42821199 · Audiologist-Guided Multimodal AI for Pure-Tone Audiometry and Tympanometry Interpretation and Reporting. · 7/10 · Diagnostics 42822722 · Deep Learning-Based Detection of Radiolucent Jaw Lesions on Panoramic Radiographs: A Comparative Study. · 6/10 · Diagnostics 42822592 · Artificial Intelligence applied to surgical pathology in the management of cutaneous melanoma. · 6/10 · Diagnostics 42820098 · Current and Future Applications of AI-Driven Predictive Modeling and a Proposed Framework for AI-Bioprognostics in Kidney Care. · 6/10 · Diagnostics
Precision oncology and genomic medicine
42823335 · Incidental detection of JAK2 V617F mutations in next-generation sequencing analysis of solid tumours: a guide to further workup. · 7/10 · Genomics/Precision Medicine 42823157 · Molecular Profiling of Archival Tonsillar Squamous Cell Carcinoma in a Korean Pre-HPV-vaccination Cohort. · 7/10 · Genomics/Precision Medicine 42823150 · Impact of Resection Margin Width on Local Control and Prognostic Factors in HER2-enriched and Triple-negative Breast Cancer in the Modern Systemic Treatment Era. · 7/10 · Genomics/Precision Medicine 42822843 · Association of HRD Score With Efficacy of Neoadjuvant Short-Course Radiotherapy Plus Sequential Chemoimmunotherapy in pMMR Locally Advanced Rectal Cancer. · 6/10 · Genomics/Precision Medicine 42823054 · New and Novel Agents for Advanced Bladder Cancer. · 5/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42823186 · Clinical Outcomes of Ramucirumab Plus Taxane After Immune Checkpoint Inhibitor Therapy in HER2-negative Advanced Gastric Cancer. · 7/10 · Treatment Innovation 42823164 · Clinical Determinants Influencing First-line Immune Checkpoint Inhibitor Selection for Unresectable Hepatocellular Carcinoma in Japan. · 7/10 · Treatment Innovation 42823161 · Baseline Gut Microbiota Composition Links Immune-nutritional Status to Clinical Outcomes in Non-small Cell Lung Cancer Treated With Atezolizumab-based Immunotherapy: A Multicenter Prospective Study. · 7/10 · Treatment Innovation 42823199 · Epigenetic programming via lysine-specific demethylase 1 regulates responses to immune checkpoint blockade. · 5/10 · Treatment Innovation 42823159 · CLSPN Is Expressed in Pancreatic Cancer and Can Be a Target for Immunotherapy. · 4/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42823338 · Plasma heart-type fatty acid-binding protein, omega-3 fatty acids and adverse cardiac events in the general population. · 7/10 · Public Health 42823110 · Tirzepatide safety in EudraVigilance: descriptive and disproportionality analysis of preferred terms related to suboptimal treatment outcomes and drug-use-related issues. · 7/10 · Public Health 42822844 · Association of Aspirin With Improved Clinical Outcomes and Survival in Patients With Compensated Cirrhosis: A Propensity Score-Matched Study of 25 782 Individuals. · 7/10 · Public Health 42822834 · Pasture-Raised Red Meat Compared with Plant-Based Meat Alternatives Within Healthy Dietary Patterns: Effects on Polyunsaturated Fatty Acid Status and Cardiometabolic Health in a Randomized Dietary Intervention. · 7/10 · Public Health 42822802 · Alterations of OCTA-Derived Iris Vessel Density and Therapeutic Responsiveness in Patients with Diabetic Retinopathy with Neovascular Glaucoma. · 7/10 · Public Health
Aging, longevity, and population health
42823163 · Prior Extrapulmonary Malignancy and Outcomes After Lung Cancer Resection. · 7/10 · Public Health 42823113 · Association between peripheral platelet markers and motoric cognitive risk syndrome: a cross-sectional analysis of data from the WCHAT study. · 7/10 · Public Health 42823108 · Primary care determinants for timely diagnosis of dementia. · 7/10 · Public Health 42820907 · Telomere Length Profile and Associated Clinical Factors among Tuberculosis Patients in Indonesia. · 7/10 · Public Health 42820550 · Life-sustaining therapy limitation in critical illness: unequal weights of demographics, disease severity, and comorbidities. · 7/10 · Public Health
Rare diseases with high unmet need
42822866 · Molecular basis of mucopolysaccharidosis IVA in a large cohort: genotype-phenotype correlations and reporting of 12 novel GALNS variants. · 7/10 · Genomics/Precision Medicine 42822393 · Muscle ATP homeostasis and exercise: insights from ADSS1 myopathy. · 7/10 · Genomics/Precision Medicine 42821922 · All-optical microwave signal generation based on a DFB laser self-injection-locked to a fiber Fabry-Perot resonator. · 7/10 · Genomics/Precision Medicine 42821898 · Dual-polarization broadband directional thermal emitter via coupled Fabry-Perot and Berreman modes. · 7/10 · Genomics/Precision Medicine 42823318 · Pushing the Boundaries of Knowledge in Alpha-1 Antitrypsin Deficiency. · 6/10 · Genomics/Precision Medicine
💡 UNSOLICITED FINDS
42823304 · Continuous vs intermittent meropenem administration in critically ill patients and renal function. A secondary post-hoc analysis of the MERCY trial. · 8/10 · Having a lower eGFR was associated with a reduced emergence of PDR/XDR pathogens.
📊 TODAY'S BREAKDOWN
- By research category: Diagnostics 9, Early Detection 6, Genomics/Precision Medicine 10, Other 9, Public Health 10, Treatment Innovation 7
- By evidence maturity: Exploratory 42, Validated 9
- Hematologic malignancies: 15 reviewed / 5 kept / highest 10
- CBC-based diagnostics and machine learning in hematology: 1 reviewed / 0 kept / highest 0
- Early cancer detection: 15 reviewed / 6 kept / highest 7
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 9 kept / highest 9
- Precision oncology and genomic medicine: 15 reviewed / 5 kept / highest 7
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 7 kept / highest 9
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 5 kept / highest 7
- Aging, longevity, and population health: 15 reviewed / 5 kept / highest 7
- Rare diseases with high unmet need: 15 reviewed / 5 kept / highest 7
- By source type: peer_reviewed 51 | preprint 0
- Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology, Precision oncology and genomic medicine, Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk, Aging, longevity, and population health, Rare diseases with high unmet need
🔧 RUN NOTES
- Complete capped coverage: 124 unique PMIDs; all verified in ESummary and EFetch.
- No window expansion was needed because the retained corpus exceeded five relevant records.
- Default exclusions and topic false positives were removed conservatively.
- Same-date article coverage was regenerated in full; duplicate Telegram alerts remain suppressed.