📅 PUBMED DAILY TRIAGE — 2026-10-05 Window: 2026-10-04T09:00:00Z → 2026-10-05T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: 56 | Candidates evaluated: 60 High priority: 8 | Standard: 23 | Low/archive: 0 | Unsolicited finds: 7 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
42829896 · Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein SL-172154 (SIRPα-Fc-CD40L) in patients with higher-risk myelodysplastic syndrome or acute myeloid leukemia. · 9/10 · SL-172154 plus AZA was generally well tolerated with favorable CR rates in pts with TP53m HR-MDS or AML, although without substantial improvement in OS when compared to historical benchmarks for AZA or AZA/VEN, respectively.
CBC-based diagnostics and machine learning in hematology
CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 0/10).
Early cancer detection
42830062 · BRIDGING THE COVERAGE-PARTICIPATION GAP: BEHAVIORAL DETERMINANTS OF CERVICAL CANCER SCREENING AMONG WOMEN IN ADJARA, GEORGIA. · 8/10 · The low HPV vaccination rate and moderate willingness to be vaccinated further support the need for integrated CCa prevention strategies linking screening promotion with HPV vaccination communication. 42830000 · Exonuclease III-Proofread high-fidelity primer exchange reaction enables ultrasensitive analysis of prostate cancer MicroRNA. · 5/10 · Using miR-21, a prostate cancer-associated biomarker, as a model, the Hf-PER assay achieves a remarkable limit of detection of 0.15 fM with a wide dynamic range spanning five orders of magnitude and single-base discrimination capability.
AI/ML in clinical diagnostics and imaging
AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate scored 5/10).
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
Novel therapeutics: immunotherapy, CAR-T, targeted therapy: No high-priority finds today (best candidate scored 6/10).
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42829714 · Prior Use of GLP-1 Receptor Agonists versus SGLT2 Inhibitors and Clinical Outcomes After Sepsis in Patients with Type 2 Diabetes: A Propensity Score-Matched Cohort Study. · 9/10 · Among propensity-matched patients with type 2 diabetes who developed sepsis, prior GLP-1 receptor agonist use was associated with lower 90-day mortality and selected cardiovascular and renal risks than prior SGLT2 inhibitor use, although residual confounding remains possible.
Aging, longevity, and population health
Aging, longevity, and population health: No high-priority finds today (best candidate scored 5/10).
Rare diseases with high unmet need
42830026 · Cardiovascular complications in adults with clinically diagnosed osteogenesis imperfecta: A cross-sectional study with echocardiography and magnetic resonance imaging. · 8/10 · This study revealed an increased prevalence of valvular heart disease, UIAs, and possibly intracranial arterial tortuosity and cortical atrophy among adults with clinically diagnosed OI. 42829928 · Cost-effectiveness of etranacogene dezaparvovec compared to eftrenonacog alfa for the treatment of adult patients with severe and moderately severe haemophilia B in Sweden. · 8/10 · Etranacogene dezaparvovec was modeled as more effective and cost-saving than eftrenonacog alfa for adults with severe or moderately severe hemophilia B in Sweden.
Precision oncology and genomic medicine
Precision oncology and genomic medicine: No high-priority finds today (best candidate scored 6/10).
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
42830144 · Reactive oxygen species define leukemia stem cell identity in pediatric acute myeloid leukemia. · 7/10 · Treatment Innovation 42830066 · DETECTION OF HEPATITIS B AND C VIRAL INFECTION AMONG CHILDREN WITH ACUTE LEUKAEMIA. · 7/10 · Diagnostics 42829584 · A Review of Thrombopoietin Receptor Agonists and Subsequent Development of Thrombosis: Exploring a Hematologic Paradox. · 5/10 · Treatment Innovation
CBC-based diagnostics and machine learning in hematology
No retained standard-priority articles.
Early cancer detection
42830000 · Exonuclease III-Proofread high-fidelity primer exchange reaction enables ultrasensitive analysis of prostate cancer MicroRNA. · 5/10 · Early Detection
AI/ML in clinical diagnostics and imaging
42829544 · Advancing Ultrasound Beamforming With Deep Learning: A Comprehensive Review of Methods, Datasets, Benchmarks, and Computational Challenges. · 5/10 · Diagnostics
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42830131 · Modern multidisciplinary management of brain metastasis. · 6/10 · Treatment Innovation 42830063 · PD-L1 EXPRESSION AND SERUM CA125: CLINICOPATHOLOGICAL CORRELATIONS IN HIGH-GRADE SEROUS OVARIAN CARCINOMA. · 6/10 · Treatment Innovation 42829986 · Disitamab vedotin in urothelial carcinoma patients: a clinical trial perspective from ARON working group. · 6/10 · Treatment Innovation 42829718 · Spatial Fibroblast-Macrophage Niches in Gastric Cancer: Mechanisms of Immune Exclusion, Therapeutic Resistance, and Targeted Intervention. · 6/10 · Treatment Innovation 42830119 · Development of bi-functional hybrid IgGA antibodies for enhancing cancer immunotherapy. · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42830218 · Glucagon-Like Peptide-1 Receptor Agonists in Pregnancy: Periconception Exposure and Perinatal Outcomes. · 7/10 · Treatment Innovation 42830034 · IMPACT OF STEM CELL THERAPY ADDED TO GUIDELINE-DIRECTED MEDICAL THERAPY ON QUALITY OF LIFE IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY. · 7/10 · Treatment Innovation 42829622 · Identification of Risk Factors and Prediction Models for Acute Kidney Injury in Hospitalized Elderly Patients with Heart Failure. · 7/10 · Other 42829576 · Cardiac Resynchronization as an Enabler of ARNI Efficacy: Insights From a Real-World Cohort. · 7/10 · Treatment Innovation 42829529 · Impact of Inflammatory Bowel Disease on Outcomes After Coronary Interventions: A Systematic Review and Meta-Analysis. · 7/10 · Treatment Innovation
Aging, longevity, and population health
42830108 · Comparison of the Properties of PARP1 and HPF1 in Naked Mole-Rat and Human. · 5/10 · Other
Rare diseases with high unmet need
42829942 · Ultrafast Micrometric Laser Structuring of Polymer Surfaces for Highly Organized Skeletal Muscle Tissue Modeling. · 5/10 · Diagnostics
Precision oncology and genomic medicine
42829510 · Mechanisms of Resistance to Targeted Therapy in Epidermal Growth Factor Receptor (EGFR)- and Anaplastic Lymphoma Kinase (ALK)-Mutated Non-small Cell Lung Cancer: Molecular Basis, Emerging Biomarkers, and Therapeutic Strategies. · 6/10 · Genomics/Precision Medicine 42829725 · Can We Extend Beyond 2 Years of Adjuvant ALK TKI Established by ALINA and ELEVATE in Resected Early Stage ALK+ NSCLC a Disease with High Predilection for CNS Metastasis with Novel Clinical Trial Designs? · 5/10 · Genomics/Precision Medicine
💡 UNSOLICITED FINDS
42830210 · Child and Adolescent All-Cause Mortality in the United States vs Peer Nations: 1935-2023. · 9/10 · Public Health 42829779 · Microwave ablation versus stereotactic body radiotherapy for oligometastatic colorectal liver metastases (LAVA-CRLM): a prospective, randomised, phase II trial. · 8/10 · Treatment Innovation 42829852 · Repeated remimazolam sedation for interstitial brachytherapy in cervical cancer: a randomized controlled trial. · 7/10 · Treatment Innovation 42829785 · Prenatal high-dose vitamin D supplementation and offspring bone mineral content and density at age 13 years: a secondary analysis of a randomised clinical trial. · 7/10 · Treatment Innovation 42830263 · Adherence to healthy plant-rich diets is associated with better olfactory function in the general population - Findings from the Cooperative Health Research in South Tyrol (CHRIS) study. · 6/10 · Public Health 42829857 · Dual-targeted nanotechnology for gynaecological cancers: a comprehensive review of mechanisms and clinical potential. · 5/10 · Treatment Innovation 42829807 · Modulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled trial. · 5/10 · Treatment Innovation
📊 TODAY'S BREAKDOWN
- By research category: Diagnostics 3; Early Detection 2; Genomics/Precision Medicine 2; Other 2; Public Health 2; Treatment Innovation 20
- By evidence maturity: Exploratory 20; Validated 11
- By source type: peer_reviewed 31
- By watchlist topic:
- Hematologic malignancies: 8 reviewed / 4 kept / highest 9
- CBC-based diagnostics and machine learning in hematology: 1 reviewed / 0 kept / highest 0
- Early cancer detection: 5 reviewed / 2 kept / highest 8
- AI/ML in clinical diagnostics and imaging: 2 reviewed / 1 kept / highest 5
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 12 reviewed / 5 kept / highest 6
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 6 kept / highest 9
- Aging, longevity, and population health: 1 reviewed / 1 kept / highest 5
- Rare diseases with high unmet need: 4 reviewed / 3 kept / highest 8
- Precision oncology and genomic medicine: 2 reviewed / 2 kept / highest 6
- Sentinel: 10 reviewed / 8 kept / highest 9
- Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology, AI/ML in clinical diagnostics and imaging, Novel therapeutics: immunotherapy, CAR-T, targeted therapy, Aging, longevity, and population health, Precision oncology and genomic medicine
🔧 RUN NOTES
- Full 24-hour CRDT window returned sufficient relevant records; no expansion was required.
- Publication-date sorting was rerun correctly after attempt 1's malformed encoded sort value; accepted ESearch responses contained no warnings.
- All capped candidates were present in both ESummary and EFetch; coverage is complete.
- Same-date rerun regenerated the complete daily corpus. Duplicate Telegram alerts were suppressed and no alert was sent by this file writer.