Daily digest · Thu · 15 Oct 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Hematologic malignancies

PMID:42874102 · Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL. · 9/10 · Randomized controlled trial; directly matches Hematologic malignancies, Novel therapeutics: immunotherapy, CAR-T, targeted therapy. Conservative abstract-level score 9/10.

CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 0/10).

Early cancer detection

PMID:42871623 · Circulating tumor DNA as a liquid biopsy for glioma detection in cerebrospinal fluid and plasma: A systematic review and meta-analysis. · 8/10 · Systematic review and meta-analysis; directly matches Early cancer detection. Conservative abstract-level score 8/10. PMID:42873295 · Contralateral DTI-ALPS index as a prognostic biomarker in IDH-wildtype glioblastoma: integrating extent of resection and sex-stratified analyses. · 8/10 · Retrospective observational study; directly matches Early cancer detection. Conservative abstract-level score 8/10. PMID:42873435 · A two-stage model combining clinical and delta-radiomics features for prognosis in high-grade gliomas after chemoradiotherapy: a retrospective study. · 8/10 · Validation study; directly matches Early cancer detection. Conservative abstract-level score 8/10.

AI/ML in clinical diagnostics and imaging

PMID:42874860 · Artificial Intelligence for Predicting Amputation and Related Outcomes in Peripheral Artery Disease: A Systematic Review and Meta-Analysis. · 9/10 · Systematic review and meta-analysis; directly matches AI/ML in clinical diagnostics and imaging. Conservative abstract-level score 9/10.

Precision oncology and genomic medicine

PMID:42874742 · Routine H&E Histology Encodes Postoperative Risk Heterogeneity in Resected Pancreatic Ductal Adenocarcinoma: A Multicohort Evaluation of TIGERS. · 9/10 · Validation study; directly matches Precision oncology and genomic medicine. Conservative abstract-level score 9/10.

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: No high-priority finds today (best candidate scored 7/10).
Aging, longevity, and population health: No high-priority finds today (best candidate scored 7/10).

Rare diseases with high unmet need

PMID:42874619 · Safety and efficacy of delpacibart zotadirsen in Duchenne muscular dystrophy mutations amenable to exon 44 skipping in the USA (EXPLORE44): a randomised, placebo-controlled, double-blind, phase 1/2 trial. · 9/10 · Randomized controlled trial; directly matches Rare diseases with high unmet need. Conservative abstract-level score 9/10.

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic malignancies

PMID:42871543 · A vision foundation model approach to quantitative bone marrow fibrosis assessment. · 6/10 · Treatment Innovation PMID:42871743 · Image-based analysis of lymphoma cell heterogeneity: Comparative study of CRYO and FFPE techniques. · 5/10 · Treatment Innovation PMID:42873197 · Open-label extension study of leniolisib in activated PI3Kδ syndrome: Long-term efficacy and safety. · 5/10 · Treatment Innovation PMID:42874953 · Pleiotrophin: a multifunctional regulator in neurodevelopment and neuropsychiatric diseases. · 5/10 · Treatment Innovation PMID:42874964 · Aberrant splicing caused by a homozygous AK2 c.498 + 1G > A variant in a patient with reticular dysgenesis and concurrent B-cell acute lymphoblastic leukemia. · 5/10 · Treatment Innovation

CBC-based diagnostics and machine learning in hematology

No retained standard-priority finds today.

Early cancer detection

PMID:42873476 · Neoadjuvant and Perioperative Immunotherapy for Resectable Esophageal Squamous Cell Carcinoma: Current Evidence, Endpoints, and Clinical Integration. · 7/10 · Early Detection PMID:42874626 · 2022 WHO estimates for overall and human papillomavirus test-based cervical cancer screening coverage worldwide: a review and synthetic analysis. · 7/10 · Early Detection PMID:42874738 · Profile and classification of invasive fungal disease in patients with haematologic malignancies using microscopy, culture, biomarkers and polymerase chain reaction. · 7/10 · Early Detection PMID:42874753 · When Is 4Gy Enough? Defining Dose Sufficiency and Durable Control in Indolent B-Cell Lymphoma. · 7/10 · Early Detection PMID:42871535 · AI-driven multi-omics biomarkers in precision breast cancer therapeutics: from discovery to clinical translation. · 6/10 · Early Detection

AI/ML in clinical diagnostics and imaging

PMID:42873564 · Human vs Artificial Intelligence in Detecting Coronary Occlusions in ST-Elevation Myocardial Infarction: Retrospective Study. · 7/10 · Diagnostics PMID:42874426 · Machine learning-based prediction of hospital-acquired malnutrition at discharge using the GLIM criteria: A multicenter real-world study. · 7/10 · Diagnostics PMID:42871543 · A vision foundation model approach to quantitative bone marrow fibrosis assessment. · 6/10 · Treatment Innovation PMID:42873913 · DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer. · 6/10 · Diagnostics PMID:42874179 · Advancing early detection of Alzheimer's disease: from established biomarkers to future innovations. · 6/10 · Diagnostics

Precision oncology and genomic medicine

PMID:42874741 · Genomic and Transcriptomic Characterization of Angiosarcomas: Focus on Cardiac Origin. · 7/10 · Genomics/Precision Medicine PMID:42874753 · When Is 4Gy Enough? Defining Dose Sufficiency and Durable Control in Indolent B-Cell Lymphoma. · 7/10 · Early Detection PMID:42874919 · Emerging Therapeutic targets and Early-phase drug Development in Gynecological Malignancies. · 7/10 · Genomics/Precision Medicine PMID:42871768 · Disulfidptosis-based cancer therapy: Opportunity and challenge. · 6/10 · Genomics/Precision Medicine PMID:42872504 · PRAME predicting outcome in uveal melanoma. · 6/10 · Genomics/Precision Medicine

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

PMID:42873584 · Second- and third-line outcomes after selective RET inhibitor failure in RET fusion-positive metastatic lung cancer: A real-world analysis from the RET-MAP registry. · 7/10 · Treatment Innovation PMID:42874444 · Emerging immunotherapies in melanoma beyond immune checkpoint inhibitors: Vaccines, intralesional therapies, adoptive cell therapies, and T-cell engagers. · 7/10 · Treatment Innovation PMID:42874535 · PiRNA-Hsap_1847317 may serve as a novel biomarker of PD-1 inhibitor resistance in patients with advanced non-small cell lung cancer. · 7/10 · Treatment Innovation PMID:42874870 · Effectiveness of Pharmaceutical Care in Reducing the Incidence of Immune Checkpoint Inhibitor-related Pneumonitis in Patients with NSCLC: A Randomized Controlled Trial. · 7/10 · Treatment Innovation PMID:42874987 · MDK+ cancer-associated fibroblasts promote immunotherapy resistance through mitochondrial reprogramming in breast cancer. · 7/10 · Treatment Innovation

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

PMID:42874603 · GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records data. · 7/10 · Prevention PMID:42874605 · Reframing traumatic brain injury and spinal cord injury as chronic multisystem disorders: toward integrated, long-term care. · 7/10 · Prevention PMID:42875396 · Characterizing vaginal misoprostol induction in individuals with and without severe obesity. · 7/10 · Prevention PMID:42874604 · Change in HbA1c and weight after initiation of antipsychotic treatment in people with severe mental illness in England: an individual-level interrupted time-series analysis. · 6/10 · Prevention PMID:42875118 · Unraveling the aroma-producing mechanism of the xerophilic fungus Xerochrysium coryli via integrated transcriptomic and volatile metabolomic analysis. · 6/10 · Prevention

Aging, longevity, and population health

PMID:42872515 · Ambient Air Pollution Health Impacts in High-Income Countries, Part II: A Case Study in the United Arab Emirates. · 7/10 · Public Health PMID:42873239 · Prevalence and determinants of cesarean section delivery among Somali women: a multivariable analysis of a nationally representative survey. · 7/10 · Public Health PMID:42873773 · Maternal deaths on arrival: A 5-year retrospective study in a health district in South Africa. · 7/10 · Public Health PMID:42873780 · Dietary and lifestyle quality and endometrial cancer: Incidence and survivorship outcomes-An umbrella review of systematic reviews and meta-analyses. · 7/10 · Public Health PMID:42873794 · Digital patient decision aids for cancer prevention in socially disadvantaged women: A scoping review protocol. · 7/10 · Public Health

Rare diseases with high unmet need

PMID:42874741 · Genomic and Transcriptomic Characterization of Angiosarcomas: Focus on Cardiac Origin. · 7/10 · Genomics/Precision Medicine PMID:42874942 · Zein-based hybrid nanocarriers for non-viral gene delivery: A review. · 7/10 · Treatment Innovation PMID:42873357 · The small giant actor in the pathogenesis of neurodegenerative diseases: Microtubules. · 6/10 · Treatment Innovation PMID:42874343 · Allergic bronchopulmonary aspergillosis as a poor prognostic factor in cystic fibrosis patients with atelectasis. · 6/10 · Treatment Innovation PMID:42874936 · Baseline Sinonasal Phenotypes in Cystic Fibrosis Before Elexacaftor/Tezacaftor/ Ivacaftor Therapy: A Cross-Sectional Analysis. · 6/10 · Treatment Innovation

💡 UNSOLICITED FINDS

No retained high-signal out-of-watchlist items.

📊 TODAY'S BREAKDOWN

By research category: Diagnostics 5, Early Detection 8, Genomics/Precision Medicine 5, Prevention 5, Public Health 6, Treatment Innovation 16
By evidence maturity: Exploratory 18, Potentially Practice-Changing 2, Validated 25
By watchlist topic:
- Hematologic malignancies: 15 reviewed / 6 kept / highest 9
- CBC-based diagnostics and machine learning in hematology: 0 reviewed / 0 kept / highest 0
- Early cancer detection: 15 reviewed / 8 kept / highest 8
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 6 kept / highest 9
- Precision oncology and genomic medicine: 15 reviewed / 6 kept / highest 9
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 6 kept / highest 9
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 5 kept / highest 7
- Aging, longevity, and population health: 15 reviewed / 8 kept / highest 7
- Rare diseases with high unmet need: 15 reviewed / 6 kept / highest 9
By source type: peer_reviewed 45 | preprint 0
Topics with zero HIGH articles this run: CBC-based diagnostics and machine learning in hematology, Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk, Aging, longevity, and population health

🔧 RUN NOTES

Complete capped rerun; same-date prior emissions were not excluded from the daily JSON.
T2 primary and configured fallback both returned zero records.
Results exceeding caps were truncated only after PubMed publication-date ordering; all selected PMIDs were independently reconciled in ESummary and EFetch.