📅 PUBMED DAILY TRIAGE — 2026-10-16 Window: 2026-10-15T09:22:03Z → 2026-10-16T09:20:11Z (CRDT) Topics scanned: 10 | Articles reviewed: 115 | Candidates evaluated: 131 High priority: 7 | Standard: 40 | Low/archive: 0 | Unsolicited finds: 5 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies: No high-priority finds today (best candidate scored 7/10).
CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 0/10).
Early cancer detection
PMID:42879457 · Genome-Wide DNA methylation profiling of tissue-plasma pairs identifies Novel cfDNA biomarkers for the diagnosis of gastric cancer. · 8/10 · An eight-marker plasma cfDNA methylation model achieved an AUC of 0.938 in an independent test set, with 94.44% sensitivity and 75.00% specificity PMID:42879988 · Urinary cell TWIST1 methylation as a non-invasive dual biomarker: A Multicenter study for early detection and recurrence monitoring in bladder cancer. · 9/10 · In an independent multicenter cohort of 1,233 participants, urinary TWIST1 methylation detected primary bladder cancer with 88.2% sensitivity and 86.8% specificity PMID:42880206 · Immunoaffinity-enriched extracellular vesicle proteomics for high-grade serous ovarian cancer - A UKOPS nested case-control analysis. · 8/10 · An extracellular-vesicle-augmented CA-125 model achieved an AUROC of 0.97 in plasma and improved specificity over CA-125 alone in the nested case-control cohort
AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate scored 7/10).
Precision oncology and genomic medicine: No high-priority finds today (best candidate scored 7/10).
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
PMID:42879732 · First-In-Human Study of 211 At-CD45 Radioimmunotherapy With Nonmyeloablative Conditioning Hematopoietic Cell Transplantation for Adults With Hematologic Malignancies. · 9/10 · In 45 adults, first-in-human astatine-211 anti-CD45 radioimmunotherapy showed immediate cytotoxic activity and could be incorporated into conditioning, although liver toxicity limited dosing PMID:42879162 · Neoadjuvant Stereotactic Ablative Radiotherapy Before Inferior Vena Cava Thrombectomy for Renal Cell Carcinoma: A Phase 2 Nonrandomized Clinical Trial. · 8/10 · Among 21 evaluable patients, neoadjuvant SABR produced 71.4% one-year recurrence-free survival and met the prespecified phase 2 screening criterion without 90-day perioperative mortality
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: No high-priority finds today (best candidate scored 7/10).
Aging, longevity, and population health: No high-priority finds today (best candidate scored 7/10).
Rare diseases with high unmet need
PMID:42880939 · A phase 2a study with SPL84: A novel RNA-targeted approach to restore CFTR function in people with CF carrying the 3849+10 kb C→T mutation. · 9/10 · In a 17-participant randomized phase 2a trial, inhaled SPL84 was well tolerated and produced encouraging lung-function signals in cystic fibrosis with the 3849+10 kb C-to-T mutation PMID:42879111 · Safety, Efficacy, and Pharmacokinetics of Agalsidase Alfa in Treatment-Naive Chinese Patients with Fabry Disease: 52-Week Phase 3, Open-Label, Single-Arm Study. · 8/10 · In 20 treatment-naive Chinese patients with Fabry disease, agalsidase alfa was generally well tolerated and renal and cardiac measures remained stable over 52 weeks
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
PMID:42876003 · Clinical Characteristics of Coexistent Chronic Myeloid Leukemia and BCR::ABL1 Negative Myeloproliferative Neoplasms: A Retrospective Study. · 7/10 · Public Health PMID:42880545 · A Pilot Study of Condensed Busulfan, Melphalan, and Fludarabine Myeloablative Conditioning in Ex Vivo CD34-Selected Allogeneic Hematopoietic Cell Transplantation. · 7/10 · Treatment Innovation PMID:42880636 · Treatment adherence in chronic lymphocytic leukemia and chronic myeloid leukemia: an integrative review. · 6/10 · Treatment Innovation PMID:42880361 · Frailty and quality of life in a real-world multiple myeloma population. · 6/10 · Public Health PMID:42878337 · NFS1 as a Metabolic Vulnerability in Acute Myeloid Leukemia Through Iron Dysregulation and STAT1/IFIT2-Associated Signaling. · 5/10 · Treatment Innovation
CBC-based diagnostics and machine learning in hematology
No standard-priority retained articles today.
Early cancer detection
PMID:42880381 · Serum extracellular vesicle-associated SNORD54 adds diagnostic information to CEA and CYFRA21-1 in non-small cell lung cancer: a case-control development study. · 7/10 · Early Detection PMID:42876915 · Lung cancer classification and severity estimation using vision transformer-IPCNN with enhanced U-Net segmentation. · 6/10 · Early Detection PMID:42878259 · Why QALY Estimates Differ in Cervical Cancer Screening: An In-Depth Exploration Using CISNET Comparative Modeling. · 6/10 · Early Detection PMID:42876606 · Preparedness for early detection of oral cancer and oral potentially malignant disorders among Saudi dental students: a multicenter cross-sectional survey. · 5/10 · Early Detection PMID:42878176 · Integrated Viscoelastic Microfluidics for Label-Free Separation and Concentration of Circulating Tumor Cells. · 5/10 · Early Detection
AI/ML in clinical diagnostics and imaging
PMID:42880922 · [Explore the potential diagnostic markers of primary Sjögren syndrome by bioinformatics combined with machine learning]. · 7/10 · Diagnostics PMID:42881113 · Machine Learning Models Combining [ 68 Ga]Ga-PSMA-11 PET Radiomics and Clinical Features to Predict Overall Survival for Metastatic Castration-resistant Prostate Cancer Treated with [ 177 Lu]Lu-PSMA Radioligand Therapy. · 7/10 · Diagnostics PMID:42880521 · Machine-learning versus traditional scoring methods for prediction of atrial fibrillation recurrence after catheter ablation: A systematic review and meta-analysis. · 7/10 · Diagnostics PMID:42876871 · Language-supervised electrocardiogram interpretation with vision transformer. · 7/10 · Diagnostics PMID:42880582 · Machine learning integrating high-resolution T1-weighted MR radiomics of subcortical structures with blood biomarkers to identify depressed patients with a history of suicide attempts. · 6/10 · Diagnostics
Precision oncology and genomic medicine
PMID:42880381 · Serum extracellular vesicle-associated SNORD54 adds diagnostic information to CEA and CYFRA21-1 in non-small cell lung cancer: a case-control development study. · 7/10 · Early Detection PMID:42880280 · Prediction of immunotherapy response using live tumor fragments from routine clinical biopsies. · 7/10 · Genomics/Precision Medicine PMID:42881113 · Machine Learning Models Combining [ 68 Ga]Ga-PSMA-11 PET Radiomics and Clinical Features to Predict Overall Survival for Metastatic Castration-resistant Prostate Cancer Treated with [ 177 Lu]Lu-PSMA Radioligand Therapy. · 7/10 · Diagnostics PMID:42880961 · Test-Retest Repeatability of [ 18 F]FDG Uptake by Solid Tumors on PET/MRI: A Prospective, Multicenter Study Using the QIBA Protocol. · 6/10 · Genomics/Precision Medicine PMID:42877237 · Pan-cancer multi-omics analysis reveals upregulation of the POLE2 subunit of DNA polymerase epsilon and its associations with patient survival and cellular pathways beyond DNA replication. · 5/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
PMID:42879361 · Efficacy of adjuvant nivolumab versus adjuvant gemcitabine plus cisplatin/carboplatin after radical nephroureterectomy for upper tract urothelial carcinoma: a real-world analysis using a Japanese large-scale claims database. · 7/10 · Treatment Innovation PMID:42880545 · A Pilot Study of Condensed Busulfan, Melphalan, and Fludarabine Myeloablative Conditioning in Ex Vivo CD34-Selected Allogeneic Hematopoietic Cell Transplantation. · 7/10 · Treatment Innovation PMID:42880253 · Reprogramming immunosuppressive TMEs with Salmonella-delivered sialidase and COX-2 blockade synergistically enhances cancer immunotherapy. · 5/10 · Treatment Innovation PMID:42880552 · Antibody-drug conjugates as promising platform for intrahepatic cholangiocarcinoma: molecular insights, drug-delivery challenges, and emerging therapeutic targets. · 5/10 · Treatment Innovation PMID:42878337 · NFS1 as a Metabolic Vulnerability in Acute Myeloid Leukemia Through Iron Dysregulation and STAT1/IFIT2-Associated Signaling. · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
PMID:42876246 · Acute kidney disease after acute kidney injury: incidence, risk factors, and association with de novo chronic kidney disease. · 7/10 · Public Health PMID:42878408 · Longitudinal Modeling of Cardiometabolic Dysfunction in Patients With Type 2 Diabetes Using Item Response Theory. · 6/10 · Public Health PMID:42876442 · Lipoprotein(a) and early LDL-cholesterol target attainment after a first acute coronary syndrome: a real-world cohort study. · 6/10 · Public Health PMID:42876524 · Nonadherence to LLT associated with higher healthcare resource utilization and costs in a large integrated healthcare delivery system in Southern California. · 5/10 · Public Health PMID:42878177 · Modulation of the gut microbiome and resistome by antibiotic use, but not by subsequent 2'-fucosyllactose intake, in adults with overweight or obesity. · 5/10 · Public Health
Aging, longevity, and population health
PMID:42876246 · Acute kidney disease after acute kidney injury: incidence, risk factors, and association with de novo chronic kidney disease. · 7/10 · Public Health PMID:42878582 · Impact of body composition on clinical outcomes in patients with hepatocellular carcinoma: A systematic review and meta-analysis. · 7/10 · Public Health PMID:42878585 · Lower circulating angiotensinogen levels across ACLD stages are associated with hepatic dysfunction and mortality. · 6/10 · Public Health PMID:42878583 · Clinical and patient-reported predictors of days alive and out of hospital in decompensated cirrhosis. · 6/10 · Public Health PMID:42879491 · Two clusters of brain regions with distinct age-related profiles of functional connectivity in autism spectrum disorder. · 5/10 · Public Health
Rare diseases with high unmet need
PMID:42878124 · Insurance and altruism values of a novel treatment for hypophosphatasia: a stated preference survey in the United States. · 7/10 · Treatment Innovation PMID:42881074 · Model-informed dose reduction of elexacaftor/tezacaftor/ivacaftor therapy in adult people with cystic fibrosis: A simulation study. · 6/10 · Treatment Innovation PMID:42879383 · Needs and Expectations of ALS Patients and Caregivers: An Integrated Perspective. · 6/10 · Public Health PMID:42880930 · [Outcomes of adult patients with mucopolysaccharidoses type Ⅰ treated by enzyme replacement therapy]. · 5/10 · Treatment Innovation PMID:42879435 · Transcutaneous spinal cord stimulation for functional recovery in individuals with hereditary spastic paraplegia: Protocol for a pilot clinical trial. · 5/10 · Treatment Innovation
💡 UNSOLICITED FINDS
PMID:42881014 · A prognostic model for use at labour onset to estimate the risk of severe fetal compromise at birth: a retrospective, model development and validation study. · 7/10 · At a fixed screen-positive rate of 15%, 20-min Fit4Labour had a sensitivity of 33·4% (95% CI 28·31-38·56), compared with the clinical benchmark sensitivity of 39·9% (95% CI 32·59-47·18, p=0·18), and showed consistent performance across all validation datasets PMID:42878366 · Beyond HPV16/18: genotype distribution of high-risk HPV and cycle threshold values in cervical carcinogenesis spectrum. · 6/10 · High-risk HPV genotypes beyond HPV16 and HPV18 were distributed across the cervical carcinogenesis spectrum, supporting broader genotype-aware surveillance research PMID:42876449 · Clinical and Genetic Characteristics of Hereditary Arrhythmias and Cardiomyopathies in the Middle East. · 6/10 · Population-specific founder variants have been identified across multiple conditions, whereas consanguineous pedigrees have contributed to the discovery of novel disease genes and recessive mechanisms that expand the global genetic landscape of inherited cardiovascular disease PMID:42876223 · Refractory Angina Pectoris: Medical and Interventional Treatment Options. · 5/10 · The review summarizes current medical and interventional options for refractory angina and emphasizes individualized treatment selection PMID:42875898 · Rational structure-guided identification of a Bcl-2-targeting peptide with antiproliferative effects on colorectal cancer cells. · 5/10 · MTT assays demonstrated that Peptide-1 markedly inhibited the proliferation of HT29 and Colo320HSR colorectal cancer cells, while showing limited effects on normal NCM460 cells
📊 TODAY'S BREAKDOWN
- By research category: Treatment Innovation 14 | Early Detection 8 | Diagnostics 5 | Public Health 17 | Genomics/Precision Medicine 3
- By evidence maturity: Exploratory 42 | Validated 5
- By watchlist topic:
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 5 kept / highest 7/10
- Aging, longevity, and population health: 15 reviewed / 5 kept / highest 7/10
- CBC-based diagnostics and machine learning in hematology: 1 reviewed / 0 kept / highest 0/10
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 5 kept / highest 7/10
- Early cancer detection: 15 reviewed / 8 kept / highest 9/10
- Hematologic malignancies: 15 reviewed / 5 kept / highest 7/10
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 7 kept / highest 9/10
- Precision oncology and genomic medicine: 15 reviewed / 5 kept / highest 7/10
- Rare diseases with high unmet need: 15 reviewed / 7 kept / highest 9/10
- Sentinel scan: 10 reviewed / 5 kept / highest 7/10
- By source type: peer_reviewed 47 | preprint 0
- Topics with zero 8+ articles this run: AI/ML in clinical diagnostics and imaging; Aging, longevity, and population health; CBC-based diagnostics and machine learning in hematology; Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk; Hematologic malignancies; Precision oncology and genomic medicine
🔧 RUN NOTES
- Complete capped same-date rerun; prior daily emissions were not removed from retrieval or output.
- Date-granular CRDT query covered 2026/10/15 through 2026/10/16; exact checkpoint timestamps appear in the window line.
- EFetch spill files were reconciled for oversized records; endpoint coverage is complete for all selected PMIDs.
- The CBC/ML candidate was a topic false positive after abstract review, so the topic retained zero genuine articles.
- No alerts were sent by this validator-gated attempt.