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‹ Sun · 18 Oct 2026
Standard addition

Prognostic Impact of Moderate Secondary Mitral Regurgitation After Optimized Medical Therapy in Heart Failure.

Moderate valve leakage after optimal heart-failure treatment remains linked to prognosis, helping clinicians identify patients needing closer monitoring.

BACKGROUND: The prognostic significance of moderate secondary mitral regurgitation (MR) after optimized guideline-directed medical therapy (GDMT) in heart failure (HF) remains uncertain. METHODS: We analyzed 2,468 ambulatory HF patients with paired transthoracic echocardiography at baseline and after 12 months of optimized GDMT.

What the study was

Study design
Prospective paired observational study
Category
Diagnostics
Maturity
Validated
Journal
ESC heart failure

Why it surfaced

High triage score (8/10) based on study design (Prospective paired observational study) and direct clinical relevance; matched topic: Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk; flag: ⬜ Standard addition

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