Peripheral immune profiles separate disease activity stages in birdshot uveitis.
Blood immune signatures distinguish different disease stages in a rare eye inflammation, potentially enabling better monitoring and treatment decisions.
INTRODUCTION: Birdshot uveitis (BU) is a chronic, debilitating posterior uveitis strongly associated with HLA-A*29, supporting a suspected autoimmune etiology. We used high-dimensional mass cytometry and clinical stratification to characterize the peripheral immune landscape in BU and identify disease activity-dependent signatures.
What the study was
- Study design
- Cross-sectional mass cytometry cohort study
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Frontiers in immunology
Why it surfaced
Standard score (7/10) elevated to HIGH by flag UNDERSERVED_POPULATION; study design: Cross-sectional mass cytometry cohort study; matched topic: Rare diseases with high unmet need
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