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15 papers read · 15 surfaced · 6 stood out
Today's lead · Early Detection
Longitudinal methylated ctDNA increases predict immunotherapy…
Blood-based DNA tests detect cancer immunotherapy failure weeks earlier than imaging, potentially enabling faster treatment adjustments for solid tumors.
Anees M, Wagner PL, Omstead A et al. · J Liq Biopsy
9/10
Impact score
Time to impact (est.)
- Lab
- Preclinical
- Early trials
- Late trials
- In practice
Novel or significantly improved treatment
CD7 chimeric antigen receptor T cells in patients with relapsed or…
First successful CAR-T cell therapy for acute myeloid leukemia opens a new treatment path for a disease lacking approved cellular therapies.
Novel or significantly improved treatmentMutation enrichment in targeted panels flags immunotherapy-responsive…
Routine genetic tests can now identify rare colorectal cancers likely to respond to immunotherapy, expanding treatment options without extra testing.
Underserved or high-risk populationsGenomic loss of MLH1/PMS2 loci defines a mismatch repair deficient…
A rare intestinal lymphoma subgroup with specific genetic changes may respond to approved immunotherapy drugs previously unavailable for this condition.
Near-term implementable findingDiagnostic performance of machine learning-based radiomics models for…
CT scan analysis using machine learning could replace biopsies to determine which lung cancer patients benefit from targeted drugs.