📅 PUBMED DAILY TRIAGE — 2026-07-04 Window: 2026-07-03T00:00:00Z → 2026-07-04T23:59:59Z (CRDT) Topics scanned: 10 | Articles reviewed: ~78 across all topics | Candidates evaluated: 83 High priority: 6 | Standard: 9 | Low/archive: 0 | Unsolicited finds: 0 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Early Cancer Detection
- PMID-42395173 · Longitudinal methylated ctDNA increases predict immunotherapy progression across solid tumors · 9/10 · Tissue-free methylation ctDNA assay identified ICI treatment failure 62 days before imaging in two prospective cohorts (n=142), with strong OS/PFS stratification — direct clinical utility for treatment switching decisions.
Hematologic Malignancies
- PMID-42399624 · CD7 chimeric antigen receptor T cells in patients with relapsed or refractory CD7-positive acute myeloid leukemia · 9/10 · First clinical proof-of-concept for CD7-targeted CAR-T in r/r AML; published in Leukemia — expands CAR-T utility beyond B-cell malignancies into high-unmet-need AML.
- PMID-42399231 · Genomic loss of MLH1/PMS2 loci defines a mismatch repair deficient subgroup in monomorphic epitheliotropic intestinal T-cell lymphoma · 8/10 · Identifies MMR-deficient MEITL subset potentially eligible for PD-1 checkpoint inhibitors — actionable biomarker in an otherwise treatment-refractory rare lymphoma.
AI and ML in Clinical Diagnostics
- PMID-42396618 · Diagnostic performance of ML-based radiomics for predicting EGFR mutation status in lung adenocarcinoma: systematic review and meta-analysis · 8/10 · Pooled meta-analysis confirms non-invasive CT radiomics as viable surrogate for tissue biopsy in EGFR testing — near-term clinical deployment path.
- PMID-42399351 · Anatomically constrained deep learning for clinical-grade volumetric pancreatic cancer segmentation: development, validation, and architectural benchmarking · 8/10 · Clinical-grade DL validation for pancreatic cancer tumor burden quantification — standardized imaging assessment addresses a staging/monitoring gap in one of oncology's highest-mortality diseases.
Precision Oncology and Genomic Medicine
- PMID-42399417 · Mutation enrichment in targeted panels flags immunotherapy-responsive POLE-driven hypermutated microsatellite-stable colorectal cancers · 8/10 · Resolves a major biomarker blind spot: identifies ~2-5% of MSS CRC patients eligible for checkpoint inhibitors using existing targeted panel sequencing infrastructure.
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic Malignancies
- PMID-42397568 · Real-world CLL multicenter study (n=1318, Greece) · 7/10 · Treatment Innovation
- PMID-42399625 · Linperlisib + MUC1-Tn CAR-T prevents exhaustion via EGR1/DUSP2 (preclinical) · 7/10 · Treatment Innovation
- PMID-42398799 · MPL Y591/R592 variants characterization in myeloid disorders · 5/10 · Genomics/Precision Medicine
Cardiovascular and Metabolic
- PMID-42398811 · GLP-1 receptor agonists in ADPKD — metabolic rationale review · 7/10 · Drug Development
- PMID-42398998 · ADHD + cardiometabolic risk in adults with T2DM — Swedish register study · 6/10 · Public Health
Aging and Longevity
- PMID-42399522 · Natural EZH2 modulators as epigenetic aging regulators · 6/10 · Other
- PMID-42399485 · RUNX1-P53 axis drives macrophage senescence in diabetic foot ulcer · 6/10 · Other
Rare Diseases with High Unmet Need
- PMID-42399698 · FDA Gene Therapy Approvals (1998-2025): regulatory evolution review · 6/10 · Drug Development
- PMID-42398348 · AQP1 AAV gene therapy for radiation-induced salivary gland damage · 6/10 · Treatment Innovation
CBC Diagnostics and ML in Hematology
- No articles kept — all 3 candidates were off-topic false positives (plant science, liver failure)
Novel Therapeutics / Sentinel Scan
- Novel Therapeutics top articles already captured above under primary topics
- Sentinel Scan: 10 candidates reviewed; no new unique HIGH articles beyond topic-specific searches
💡 UNSOLICITED FINDS
None this run.
📊 TODAY'S BREAKDOWN
By research category:
- Early Detection: 1 | Treatment Innovation: 5 | Diagnostics: 2
- Genomics/Precision Medicine: 3 | Drug Development: 2 | Public Health: 1 | Other: 2
By evidence maturity:
- Exploratory: 13 | Validated: 2 | Potentially Practice-Changing: 0
By watchlist topic (reviewed / kept / highest score):
- Hematologic Malignancies: 15 reviewed / 5 kept / 9
- CBC Diagnostics and ML in Hematology: 3 reviewed / 0 kept / 0 (all false positives)
- Early Cancer Detection: 8 reviewed / 1 kept / 9
- AI and ML in Clinical Diagnostics: 15 reviewed / 2 kept / 8
- Precision Oncology and Genomic Medicine: 10 reviewed / 3 kept / 8
- Novel Therapeutics: 7 reviewed / 4 kept (3 also in other topics) / 9
- Cardiovascular and Metabolic: 5 reviewed / 2 kept / 7
- Aging and Longevity: 5 reviewed / 2 kept / 6
- Rare Diseases with High Unmet Need: 5 reviewed / 3 kept / 7
- Sentinel Scan: 10 reviewed / 0 new / 0
By source type: peer_reviewed 15 | preprint 0
Topics with zero 8+ articles this run:
- CBC Diagnostics and ML in Hematology (T2 false-positive issue persists; 0/3 candidates valid)
- Cardiovascular and Metabolic (best score 7 for GLP-1/ADPKD review)
- Aging and Longevity (best score 6; no high-signal human aging studies in window)
- Rare Diseases with High Unmet Need (best score 7; no Phase 3/clinical trial data)
- Sentinel Scan (all signals captured by topic searches)
🔧 RUN NOTES
- Attempt 3 of 3: Schema fixes applied — evidence_maturity and access_level corrected to valid enum values (Exploratory/Validated/Abstract only); pipeline_priority aligned to score/flag rules for 4 articles (42398811, 42399625, 42397568: HIGH→STANDARD; 42398799: LOW→STANDARD); search_logs upgraded with all required fields (candidate_pmids, esummary_requested_pmids, efetch_requested_pmids, missing_pmids, coverage_complete); run_status corrected to SUCCESS.
- T2 CBC/ML topic: Yielded 0 valid candidates again — all 3 search results (PMIDs 42395324, 42394659, 42394494) were off-topic. Hemorrhage/hematoma exclusion and keyword-forward query working correctly; low-signal day for this topic.
- Precision Oncology cap: 94 raw results, only 10 candidates reviewed (partial coverage). Stricter query refinement recommended for future runs.
- Novel Therapeutics partial coverage: 109 raw results, only 7 reviewed. Several top results already captured via Hematologic Malignancies topic searches.
- No window expansion triggered: 15 articles found across all topics, exceeding the 5-article minimum.