Natural modulators of enhancer of zeste homolog 2 (EZH2): potential epigenetic regulators of aging-associated pathways.
Natural compounds may modulate aging-related epigenetic changes without the toxicity concerns of synthetic drugs, opening new longevity research directions.
EZH2 is a key epigenetic regulator whose activity changes with aging and drives transcriptional silencing of longevity-associated genes. This review in Biogerontology catalogs natural compounds that modulate EZH2, proposing a pharmacognosy-based approach to targeting epigenetic aging that avoids the toxicity concerns of synthetic EZH2 inhibitors used in oncology.
What the study was
- Study design
- review
- Population
- General (aging biology, natural compound modulation of EZH2)
- Category
- Other
- Maturity
- Exploratory
- Journal
- Biogerontology
Why it surfaced
Standard: EZH2 modulation in aging is a developing area of interest; natural compound focus limits translational immediacy; review design and small author team; relevant to aging and longevity watchlist.
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