Nonlinear Associations of Estimated Glucose Disposal Rate With Incident Age-Related Eye Diseases: Implications for Metabolic Risk Stratification.
This cohort study examined associations between estimated glucose disposal rate (eGDR), a proxy for insulin sensitivity, and incident age-related cataract and macular degeneration, revealing significant nonlinear L-shaped dose-response patterns using restricted cubic spline analysis. A steep risk decline was observed at lower eGDR levels followed by a risk-neutral plateau at higher values, supporting insulin resistance stratification as a tool for age-related eye disease risk assessment.
This cohort study examined associations between estimated glucose disposal rate (eGDR), a proxy for insulin sensitivity, and incident age-related cataract and macular degeneration, revealing significant nonlinear L-shaped dose-response patterns using restricted cubic spline analysis. A steep risk decline was observed at lower eGDR levels followed by a risk-neutral plateau at higher values, supporting insulin resistance stratification as a tool for age-related eye disease risk assessment.
What the study was
- Study design
- Cohort study
- Sample size
- 444137
- Category
- Public Health
- Maturity
- Exploratory
- Journal
- Investigative ophthalmology & visual science
Why it surfaced
Relevant Aging, longevity, and population health study (promising preliminary signal) meets standard-priority threshold.
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