Genomic Landscape of GNAQ and GNA11 Mutations in Metastatic Solid Tumors: A Real-World Data Analysis.
PURPOSE: Activating mutations in GNAQ and GNA11 are recognized oncogenic drivers in uveal melanoma (UM); however, their prevalence across various cancers and their genomic context remain inadequately characterized. CONCLUSION: This real-world analysis demonstrates that GNAQ and GNA11 mutations are not exclusive to UM, occurring across diverse solid tumors, particularly colorectal cancer.
PURPOSE: Activating mutations in GNAQ and GNA11 are recognized oncogenic drivers in uveal melanoma (UM); however, their prevalence across various cancers and their genomic context remain inadequately characterized. CONCLUSION: This real-world analysis demonstrates that GNAQ and GNA11 mutations are not exclusive to UM, occurring across diverse solid tumors, particularly colorectal cancer.
What the study was
- Study design
- Not specified
- Sample size
- 10
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- JCO precision oncology
Why it surfaced
Low-signal Precision oncology and genomic medicine entry (Not specified design); retained for topic coverage completeness.
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