Cationic nanotrap curbs UVB-induced cutaneous photodamage via exosomal cfNA capture.
Cell-free nucleic acids (cfNAs) carried by exosomes released from UVB-damaged skin cells act as damage-associated molecular patterns (DAMPs) that amplify sterile inflammation and contribute to sunburn, photoaging, and skin tumorigenesis. WSP inhibited TLR3 and 9 activation induced by nucleic-acid agonists, UVB-conditioned media from HDFs and NHEKs, and exosomes derived from UVB-damaged HDFs, indicating effective neutralization of both soluble and vesicle-associated cfNAs.
Cell-free nucleic acids (cfNAs) carried by exosomes released from UVB-damaged skin cells act as damage-associated molecular patterns (DAMPs) that amplify sterile inflammation and contribute to sunburn, photoaging, and skin tumorigenesis. WSP inhibited TLR3 and 9 activation induced by nucleic-acid agonists, UVB-conditioned media from HDFs and NHEKs, and exosomes derived from UVB-damaged HDFs, indicating effective neutralization of both soluble and vesicle-associated cfNAs.
What the study was
- Study design
- Preclinical study
- Category
- Early Detection
- Maturity
- Exploratory
- Journal
- Biomaterials
Why it surfaced
Relevant Early cancer detection study (promising preliminary signal) meets standard-priority threshold.
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