Using human 3D organoid models to gain mechanistic insight in motor neuron diseases.
This review describes the use of human 3D spinal cord organoids to investigate cell-autonomous mechanisms and motor neuron-glia interactions in motor neuron diseases such as ALS and SMA. Axially elongated spinal cord organoids and 3D neuromuscular junction models are highlighted as particularly valuable platforms for studying developmental vulnerability, muscle pathology, and neuromuscular junction dismantling in these diseases.
This review describes the use of human 3D spinal cord organoids to investigate cell-autonomous mechanisms and motor neuron-glia interactions in motor neuron diseases such as ALS and SMA. Axially elongated spinal cord organoids and 3D neuromuscular junction models are highlighted as particularly valuable platforms for studying developmental vulnerability, muscle pathology, and neuromuscular junction dismantling in these diseases.
What the study was
- Study design
- Review
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Nature reviews. Neuroscience
Why it surfaced
Relevant AI/ML in clinical diagnostics and imaging study (promising preliminary signal) meets standard-priority threshold.
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