A comprehensive plasma-based approach to thromboinflammation in bladder cancer: integrating lipidomics, thrombin generation, and NETosis biomarkers.
BACKGROUND: Lipid metabolism reprogramming is a hallmark of cancer, yet its systemic manifestations and functional implications in bladder cancer (BC) remain poorly understood. CONCLUSIONS: Plasma lipidomic profiling identifies biomarkers with diagnostic and prognostic potential in BC and reveals associations with NETosis, active DNaseI dysfunction, and thrombin generation.
BACKGROUND: Lipid metabolism reprogramming is a hallmark of cancer, yet its systemic manifestations and functional implications in bladder cancer (BC) remain poorly understood. CONCLUSIONS: Plasma lipidomic profiling identifies biomarkers with diagnostic and prognostic potential in BC and reveals associations with NETosis, active DNaseI dysfunction, and thrombin generation.
What the study was
- Study design
- Cross-sectional study
- Category
- Other
- Maturity
- Validated
- Journal
- Journal of translational medicine
Why it surfaced
Relevant Sentinel scan study (promising preliminary signal) meets standard-priority threshold.
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