A systems herbal-to-molecule and transcriptomic strategy identifies emodin as an ESR1-targeting phytochemical driving thrombopoiesis.
Radiation-induced thrombocytopenia (RIT) is a major dose-limiting toxicity of radiotherapy, for which effective pharmacological interventions remain limited. Collectively, these findings identify emodin as a key thrombopoietic constituent of RR and reveal an ESR1-centered regulatory axis in megakaryopoiesis, supporting its therapeutic potential for RIT.
Radiation-induced thrombocytopenia (RIT) is a major dose-limiting toxicity of radiotherapy, for which effective pharmacological interventions remain limited. Collectively, these findings identify emodin as a key thrombopoietic constituent of RR and reveal an ESR1-centered regulatory axis in megakaryopoiesis, supporting its therapeutic potential for RIT.
What the study was
- Study design
- Validation study
- Category
- Other
- Maturity
- Exploratory
- Journal
- Chinese medicine
Why it surfaced
Relevant Sentinel scan study (promising preliminary signal) meets standard-priority threshold.
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