Multiomic profiling links L1 retrotransposition to genomic instability and ecDNA in bladder cancer.
Retrotransposon activity in bladder cancer triggers genomic instability and immune activation, revealing new therapeutic angles.
Bladder cancer is frequent and highly recurrent. In summary, our results support a model whereby L1 retrotransposition triggers downstream genomic instability and viral mimicry response.
What the study was
- Study design
- Cohort study
- Population
- Cancer/disease patients
- Category
- Genomics/Precision Medicine
- Maturity
- Validated
- Journal
- Nature communications
Why it surfaced
Matched topic(s): Early cancer detection. Study design: Cohort study. Score 5/10.
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