Rbm5 sustains leukemia stem cells through a Myc-driven transcriptional circuitry.
A gene mutation sustains leukemia stem cells through a specific pathway, identifying a potential therapeutic target.
Acute myeloid leukemia (AML) represents a type of malignant hematological disease that is usually caused by the dysregulated developmental program of leukemia stem cells (LSCs). normal hematopoietic stem cells (HSCs) do not exhibit such changes upon Rbm5 loss.
What the study was
- Study design
- Preclinical study
- Category
- Drug Development
- Maturity
- Exploratory
- Journal
- Leukemia
Why it surfaced
Matched topic(s): Hematologic malignancies. Study design: Preclinical study. Published in high-impact journal. Score 5/10.
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