Dynamic Circulating Tumor DNA Methylation Monitoring Guiding Postoperative Surveillance in Nonmetastatic Colorectal Cancer: A Prospective, Randomized, Phase III FIND Trial.
Blood tests that detect cancer DNA after surgery help doctors catch returning colorectal cancer earlier and treat it more effectively before it spreads.
A 584-patient prospective Phase III RCT compared ctDNA methylation-guided postoperative surveillance against standard CT monitoring in nonmetastatic colorectal cancer after curative resection. ctDNA guidance doubled the rate of curative-intent therapy for recurrences and significantly improved resectability of liver/lung metastases, though long-term survival benefit awaits mature follow-up.
What the study was
- Study design
- Prospective multicenter randomized phase III RCT
- Population
- Nonmetastatic colorectal cancer patients post-curative resection
- Sample size
- 584
- Category
- Early Detection
- Maturity
- Potentially Practice-Changing
- Journal
- Journal of Clinical Oncology
Why it surfaced
Phase III prospective RCT demonstrating ctDNA methylation-guided surveillance doubles curative-intent resection of CRC recurrences; published in J Clin Oncol, directly practice-relevant to post-surgical oncology monitoring.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.