📅 PUBMED DAILY TRIAGE — 2026-07-30 Window: 2026-07-29T00:00:00Z → 2026-07-30T09:00:00Z (CRDT) Topics scanned: 9 watchlist + sentinel | Articles reviewed: ~55 candidates | Retained: 21 High priority: 3 | Standard: 18 | Low/archive: 0 | Unsolicited finds: 0 Run status: PARTIAL_SUCCESS (coverage partial: 5-13 of 15 candidates per topic reviewed)
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- PMID 42527400 · A distinct CAR-T cell phenotype mediates therapeutic response at limited doses.... · 8/10 · Functional effector and effector memory-like CAR-T cell abundance—not total dose—robustly predicted clinical response ac...
- PMID 42526889 · Impact of EBV Status and Histology on Patient Outcomes with Nivolumab-AVD vs BV-... · 8/10 · Nivolumab-AVD achieved 3-year PFS of 91% vs 70% (HR 0.30, P=0.01) in EBV-positive cHL and 86% vs 63% (HR 0.33, P=0.006) ...
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
- PMID 42525894 · Dynamic Circulating Tumor DNA Methylation Monitoring Guiding Postoperative Surve... · 9/10 · ctDNA methylation-guided surveillance significantly increased curative-intent therapy for recurrence (48.1% vs 23.6%, RR...
Precision oncology and genomic medicine
- PMID 42525894 · Dynamic Circulating Tumor DNA Methylation Monitoring Guiding Postoperative Surve... · 9/10 · ctDNA methylation-guided surveillance significantly increased curative-intent therapy for recurrence (48.1% vs 23.6%, RR...
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- PMID 42527400 · A distinct CAR-T cell phenotype mediates therapeutic response at limited doses.... · 8/10 · Functional effector and effector memory-like CAR-T cell abundance—not total dose—robustly predicted clinical response ac...
- PMID 42526889 · Impact of EBV Status and Histology on Patient Outcomes with Nivolumab-AVD vs BV-... · 8/10 · Nivolumab-AVD achieved 3-year PFS of 91% vs 70% (HR 0.30, P=0.01) in EBV-positive cHL and 86% vs 63% (HR 0.33, P=0.006) ...
Topics with no HIGH priority articles today:
- CBC-based diagnostics and machine learning in hematology: No 8+ articles today (best candidate scored 4/10)
- AI/ML in clinical diagnostics and imaging: No 8+ articles today (best candidate scored 6/10)
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: No 8+ articles today (best candidate scored 7/10)
- Aging, longevity, and population health: No 8+ articles today (best candidate scored 6/10)
- Rare diseases with high unmet need: No 8+ articles today (best candidate scored 6/10)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- PMID 42527666 · Adaptor-mediated rewiring of FLT3 signaling engages p38 MAPK to sustai... · 7/10 · Drug Development
- PMID 42526888 · Characteristics of Donor and Recipient Clonal Hematopoiesis in Nonmyel... · 7/10 · Genomics/Precision Medicine
- PMID 42526849 · Comprehensive Driver Mutation Landscape of DLBCL Informed by Integrate... · 6/10 · Genomics/Precision Medicine
- PMID 42527721 · Follicular Lymphoma: Novel Therapies and Strategies for Optimal Therap... · 5/10 · Treatment Innovation
- PMID 42526649 · Prognostic Value of Metabolic Tumor Volume in Stage I-II Extranodal NK... · 5/10 · Diagnostics
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
- PMID 42527101 · Stable Wet-Fixed S-MPF Preparation for Enhanced Circulating Tumor-asso... · 5/10 · Early Detection
AI/ML in clinical diagnostics and imaging
- PMID 42527793 · Towards Explainability in Deep Learning for Detection of Five Major In... · 6/10 · Diagnostics
- PMID 42527905 · Artificial intelligence for pediatric fracture detection: impact on di... · 6/10 · Diagnostics
- PMID 42527576 · Human-in-the-loop AI predictive digital twin to extend virtual precisi... · 5/10 · Diagnostics
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- PMID 42527663 · NLRC3 enhances antitumor immunity by specifically negatively regulatin... · 6/10 · Drug Development
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- PMID 42527732 · Clinical Trial: Phase 3 Trial of Resmetirom Versus Placebo in Metaboli... · 7/10 · Treatment Innovation
- PMID 42527728 · Epigenetic aging biomarkers in dietary geroscience: feasibility, parti... · 5/10 · Prevention
Aging, longevity, and population health
- PMID 42524887 · Progerin Hinders Autophagy Flux at Its Final Stages in Hutchinson-Gilf... · 6/10 · Drug Development
- PMID 42524598 · Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in A... · 5/10 · Drug Development
- PMID 42525830 · Beyond atypicality: reframing the clinical presentation of acute illne... · 5/10 · Public Health
Rare diseases with high unmet need
- PMID 42524523 · Genotype-based severity scoring system in Wolfram Syndrome: correlatio... · 6/10 · Genomics/Precision Medicine
- PMID 42526191 · A novel ASCC1 splice-site variant broadens the phenotypic spectrum of ... · 5/10 · Genomics/Precision Medicine
- PMID 42525369 · Regulatory Alignment on Surrogate Endpoints for Slowly Progressive Ult... · 5/10 · Drug Development
💡 UNSOLICITED FINDS
None above threshold today — sentinel scan found no high-signal out-of-watchlist articles.
📊 TODAY'S BREAKDOWN
By research category:
- Drug Development: 5
- Treatment Innovation: 4
- Genomics/Precision Medicine: 4
- Diagnostics: 4
- Early Detection: 2
- Prevention: 1
- Public Health: 1
By evidence maturity:
- Exploratory: 16
- Potentially Practice-Changing: 3
- Validated: 2
By watchlist topic (reviewed / retained / highest score):
- Hematologic malignancies (AML, MDS, CLL, MPN, lymp: reviewed=13, high=2, std=5, best=8
- CBC-based diagnostics and machine learning in hema: reviewed=2, high=0, std=0, best=4
- Early cancer detection (liquid biopsy, ctDNA, cfDN: reviewed=5, high=1, std=2, best=9
- AI/ML in clinical diagnostics and imaging: reviewed=5, high=0, std=2, best=6
- Precision oncology and genomic medicine: reviewed=5, high=0, std=1, best=5
- Novel therapeutics: immunotherapy, CAR-T, targeted: reviewed=5, high=0, std=1, best=6
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometa: reviewed=5, high=0, std=3, best=7
- Aging, longevity, and population health: reviewed=5, high=0, std=3, best=6
- Rare diseases with high unmet need: reviewed=5, high=0, std=4, best=6
By source type: peer_reviewed: 22 | preprint: 0
Topics with zero 8+ articles this run:
- CBC-based diagnostics and machine learning in hematology
- AI/ML in clinical diagnostics and imaging
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- Aging, longevity, and population health
- Rare diseases with high unmet need
🔧 RUN NOTES
- PARTIAL_SUCCESS: 8 of 10 topics reviewed at only 5 of 15 candidate cap due to API response budget constraints.
- T2 CBC/ML: Only 2 results in 24h CRDT window (below 5-record expansion threshold); 48h expansion deferred.
- T1 truncation: esummary batch containing PMIDs 42527129, 42527076 was truncated; both excluded from review.
- Sentinel: No high-signal unsolicited finds detected.
- Coverage gap: ~100 candidate PMIDs across topics not reviewed this run due to partial coverage.
- Attempt 2 of 3 (repaired). Validator will check schema compliance before promotion to final paths.