Targeting peripheral 5-HT(2A)R enhances antitumor immunity in colorectal cancer.
A gut-targeted serotonin receptor drug helps immune cells fight colorectal cancer without affecting the brain, potentially improving treatment response in patients with hard-to-treat tumors.
- Lab
- Preclinical
- Early trials
- Late trials
- In practice
Early-life sugar restriction causally reduces adult cancer incidence…
Children who consumed less sugar in their first thousand days had substantially lower cancer rates decades later, suggesting early nutrition shapes lifelong disease risk.
Novel or significantly improved treatmentFunctional restoration of immune defects in STAT1 gain-of-function…
Researchers corrected a dangerous genetic immune defect in patients' own blood cells using precision gene editing, restoring normal immune function without genetic damage.
Near-term implementable findingOptical genome mapping refines diagnosis of high-grade myeloid…
A new imaging technique found twice as many hidden genetic changes in blood cancers that standard tests miss, enabling better diagnosis and prognosis for patients.
Early cancer detection or preventionIntegrative cfDNA profiling from low-pass whole-genome sequencing…
A blood test combining multiple DNA signals accurately identifies where a cancer started in 4 out of 5 patients, helping doctors choose the right treatment.